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Erschienen in: Cancer Chemotherapy and Pharmacology 2/2011

01.08.2011 | Original Article

Clinical impact of K-ras mutation in colorectal cancer patients treated with adjuvant FOLFOX

verfasst von: Myung Hee Chang, In Kyu Lee, Yoon Si, Kyu Sang Lee, In-Sook Woo, Jae Ho Byun

Erschienen in: Cancer Chemotherapy and Pharmacology | Ausgabe 2/2011

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Abstract

Background

K-ras proto-oncogene is commonly mutated in colorectal cancer (CRC) and has been associated with predictive markers for anti-EGFR (epidermal growth factor receptor) therapy. However, the prognostic role of K-ras status is still unclear. The aim of this study was to evaluate the association between k-ras status and addition of oxaliplatin to fluorouracil plus leucovorin (FOLFOX) chemotherapy in CRC patients with curative surgical resection.

Methods

Sixty-six patients with stage II or III CRC were treated with FOLFOX or fluorouracil plus leucovorin (FL) followed by curative surgery between January 2004 and October 2007. K-ras status was assessed by direct sequencing.

Results

Fifteen patients (22.7%) had K-ras mutations of codon 12 (11/15) or codon 13 (4/15). There were no significant differences in clinicopathological parameters, such as age, sex, stage, or adjuvant regimen between the wild-type K-ras and mutant K-ras. With a median follow-up of 41.6 months (range 25.1–72.3 months), median disease-free survival (DFS) and overall survival (OS) were not reached. With regard to K-ras status, DFS and OS were not statistically different (P = 0.269 and P = 0.917, respectively). Even in the group treated with FOLFOX only, neither DFS (P = 0.651) nor OS (P = 0.265) was significantly different according to K-ras status. With the exception of tumor location in DFS and OS, no differences in other variables were observed. Proximal colon cancer patients had a longer DFS than distal CRC patients (P = 0.079); this trend was maintained only in the wild-type K-ras group (P = 0.051).

Conclusions

These results showed that K-ras status was not associated with clinical outcome in patients treated with adjuvant FOLFOX.
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Metadaten
Titel
Clinical impact of K-ras mutation in colorectal cancer patients treated with adjuvant FOLFOX
verfasst von
Myung Hee Chang
In Kyu Lee
Yoon Si
Kyu Sang Lee
In-Sook Woo
Jae Ho Byun
Publikationsdatum
01.08.2011
Verlag
Springer-Verlag
Erschienen in
Cancer Chemotherapy and Pharmacology / Ausgabe 2/2011
Print ISSN: 0344-5704
Elektronische ISSN: 1432-0843
DOI
https://doi.org/10.1007/s00280-010-1496-5

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