Ausgabe 7/2016
Inhalt (11 Artikel)
Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations
Carmen Walter, Claudia Knothe, Jörn Lötsch
A Comprehensive Review of Novel Drug–Disease Models in Diabetes Drug Development
Puneet Gaitonde, Parag Garhyan, Catharina Link, Jenny Y. Chien, Mirjam N. Trame, Stephan Schmidt
Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics
Katherine L. Gill, Krishna K. Machavaram, Rachel H. Rose, Manoranjenni Chetty
Pharmacokinetics of Cannabis in Cancer Cachexia-Anorexia Syndrome
Stephanie E. Reuter, Jennifer H. Martin
Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection
Andreas Krause, Jochen Zisowsky, Daniel S. Strasser, Martine Gehin, Patricia N. Sidharta, Peter M. A. Groenen, Jasper Dingemanse
Combining ‘Bottom-Up’ and ‘Top-Down’ Methods to Assess Ethnic Difference in Clearance: Bitopertin as an Example
Sheng Feng, Jun Shi, Neil Parrott, Pei Hu, Cornelia Weber, Meret Martin-Facklam, Tomohisa Saito, Richard Peck
Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen
Anne van Rongen, Pyry A. J. Välitalo, Mariska Y. M. Peeters, Djamila Boerma, Fokko W. Huisman, Bert van Ramshorst, Eric P. A. van Dongen, Johannes N. van den Anker, Catherijne A. J. Knibbe
Propofol Breath Monitoring as a Potential Tool to Improve the Prediction of Intraoperative Plasma Concentrations
Pieter Colin, Douglas J. Eleveld, Johannes P. van den Berg, Hugo E. M. Vereecke, Michel M. R. F. Struys, Gustav Schelling, Christian C. Apfel, Cyrill Hornuss
Comprehensive Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Evaluation of Once-Daily Efavirenz 400 and 600 mg in Treatment-Naïve HIV-Infected Patients at 96 Weeks: Results of the ENCORE1 Study
Laura Dickinson, Janaki Amin, Laura Else, Marta Boffito, Deirdre Egan, Andrew Owen, Saye Khoo, David Back, Catherine Orrell, Amanda Clarke, Marcelo Losso, Praphan Phanuphak, Dianne Carey, David A. Cooper, Sean Emery, Rebekah Puls
Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels
Hannah M. Jones, Richard P. Butt, Rob W. Webster, Ian Gurrell, Pawel Dzygiel, Neil Flanagan, Daniela Fraier, Tanya Hay, Laura Else Iavarone, Jacquelynn Luckwell, Hannah Pearce, Alex Phipps, Jill Segelbacher, Bill Speed, Kevin Beaumont
Single- and Multiple-Dose Milnacipran Pharmacokinetics in Healthy Han Chinese Volunteers
Can-Jun Ruan, An-Ning Li, Fang Dong, Yi-Min Zhai, Wen-Biao Li, Chuan-Yue Wang, Jose de Leon