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Erschienen in:
01.07.2015 | Original Article
Clinical Profile of Children with Malformations of Cortical Development
Erschienen in: Indian Journal of Pediatrics | Ausgabe 7/2015
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Objective
To elucidate the clinical-radiological profile of children with malformations of cortical development.
Methods
This observational study was conducted at a tertiary care child hospital of north India. Clinical-radiological data records were reviewed and assessment of children’s functioning in five key areas of physical, adaptive behavior, social emotional, cognitive and communication was performed using Developmental Profile-3.
Results
Sixty-four cases of “Malformations of cortical development” were studied. The commonest malformations were lissencephaly (14/64), agyria-pachygyria (14/64) and schizencephaly (14/64). Focal cortical dysplasia (n = 12), hemimegalencephaly (n = 4), polymicrogyria (n = 3) and heterotopias (n = 3) were the other malformations seen. On Developmental Profile-3, 90 % children had developmental delay.
Conclusions
The present study provides important data on the pattern of malformations of cortical development seen in a tertiary care hospital. It emphasizes that all children with developmental delay and seizures should be evaluated with magnetic resonance imaging.