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Current Osteoporosis Reports

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18.06.2018 | Bone and Joint Pain (T King and S Amin, Section Editors)

Clinical Relevance of Joint Hypermobility and Its Impact on Musculoskeletal Pain and Bone Mass

verfasst von: Vito Guarnieri, Marco Castori

Erschienen in: Current Osteoporosis Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

To summarize current evidence on the links between joint hypermobility (JH) and Ehlers-Danlos syndromes (EDS), with pain and reduced bone mass; to illustrate an updated approach to JH and EDS.

Recent Findings

In 2017, a novel classification for EDS and JH has been published. Increasing data demonstrate that pain is a major disability determinator in JH and EDS. Recent findings confirm a complex pathogenesis for pain in JH and EDS and suggest a potential role for joint instability, central sensitization and small fiber neuropathy. Some papers present bone mass reduction as an associated feature of JH and EDS. The association is preliminary and reflects heterogeneous mechanisms.

Summary

Assessment of patients with JH/EDS is now well-structured and based on an integrated approach of clinical evaluations and molecular testing. Pain and reduced bone mass are possibly common satellite manifestations of JH/EDS and need expert consult for appropriate interpretation and management.

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Titel: Clinical Relevance of Joint Hypermobility and Its Impact on Musculoskeletal Pain and Bone Mass
verfasst von: Vito Guarnieri
Marco Castori
Publikationsdatum: 18.06.2018
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 4/2018
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-018-0460-x

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