Background
Methods
Study population
Methylation-specific PCR(MSP)
Statistical analysis
Results
Patients’ characteristics
Frequency of PCDH10 promoter methylation in DLBCL
Correlation of PCDH10 methylation and clinicopathological characteristics
PCDH10 Methylation |
p value | ||
---|---|---|---|
Yes (n = 58) | No (n = 49) | ||
Age at diagnosis | |||
<60y | 39 | 28 | 0.282 |
≥ 60y | 19 | 21 | |
Sex | |||
Male | 30 | 28 | 0.575 |
Female | 28 | 21 | |
Primary site | |||
Extranodal | 28 | 17 | 0.156 |
Nodala
| 30 | 32 | |
IPI risk category | |||
Low | 26 | 22 | 0.683 |
Low-intermediate | 15 | 15 | |
High-intermediate | 13 | 7 | |
High | 4 | 5 | |
Hans Algorithm | |||
GCB | 14 | 19 | 0.102 |
Non-GCB | 44 | 30 | |
MYC FISH Breakapart | |||
No | 55 | 43 | 0.296a
|
Yes | 3 | 6 |
Survival analysis of DLBCL with RCHOP treatment
OS | ||||
---|---|---|---|---|
HR_U(95%CI) |
p value | HR_M(95%CI) |
p value | |
Age at diagnosis | ||||
<60y | 1.000 | |||
≥ 60y | 1.393(0.549–3.535) | 0.485 | ||
Sex | ||||
Male | 1.000 | |||
Female | 0.426(0.160–1.137) | 0.088 | ||
Primary site | ||||
Extranodal | 1.000. | |||
Nodala
| 2.267(0.744-6.911) | 0.150 | ||
IPI risk category | ||||
Low | 1.000 | 1.000 | ||
Low-intermediate | 2.029(0.545–7.559) | 0.292 | 2.510(0.669–9.421) | 0.173 |
High-intermediate | 3.385(0.976–11.746) | 0.055 | 2.836(0.815–9.873) | 0.101 |
High | 5.487(1.467–20.517) | 0.011 | 6.986(1.845–26.450) | 0.004 |
Treatment | ||||
RCHOP | 1.000 | |||
Resection & RCHOP | 0.152(0.020–1.145) | 0.067 | ||
Hans Algorithm | ||||
GCB | 1.000 | |||
Non-GCB | 1.419(0.505–3.984) | 0.506 | ||
PCDH10 Methylation | ||||
No | 1.000 | 1.000 | ||
Yes | 3.547(1.166–10.791) | 0.026 | 4.045(1.287–12.711) | 0.017 |
MYC FISH Breakapart | ||||
No | 1.000 | |||
Yes | 1.285(0.170–9.713) | 0.808 |
PFS | ||||
---|---|---|---|---|
HR_U(95%CI) |
p value | HR_M(95%CI) |
p value | |
Age at diagnosis | ||||
<60y | 1.000 | |||
≥ 60y | 1.557(0.731–3.314) | 0.251 | ||
Sex | ||||
Male | 1.000 | |||
Female | 1.067(0.501–2.272) | 0.867 | ||
Primary site | ||||
Extranodal | 1.000 | |||
Nodala
| 2.422(0.976-6.007) | 0.056 | ||
IPI risk category | ||||
Low | 1.000 | 1.000 | ||
Low-intermediate | 2.456(0.825–7.313) | 0.107 | 2.474(0.829–7.389) | 0.105 |
High-intermediate | 3.895(1.360–11.151) |
0.011
| 3.687(1.259–10.795) |
0.017
|
High | 9.202(3.156–26.832) |
<0.001
| 8.680(2.874–26.215) |
<0.001
|
Treatment | ||||
RCHOP | 1.000 | 1.000 | ||
Resection & RCHOP | 0.090(0.012–0.668) |
0.018
| 0.119(0.016–0.903) |
0.040
|
Hans Algorithm | ||||
GCB | 1.000 | |||
Non-GCB | 1.410(0.617–3.222) | 0.415 | ||
PCDH10 Methylation | ||||
No | 1.000 | 1.000 | ||
Yes | 2.687(1.173–6.156) |
0.019
| 2.977(1.245–7.119) |
0.014
|
MYC FISH Breakapart | ||||
No | 1.000 | |||
Yes | 0.716(0.097–5.279) | 0.743 |