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Zeitschrift

BMC Cancer

BMC Cancer 1/2017

Ausgabe 1/2017

Inhaltsverzeichnis ( 906 Artikel )

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Nutrition therapy with high intensity interval training to improve prostate cancer-related fatigue in men on androgen deprivation therapy: a study protocol

Brenton J. Baguley, Tina L. Skinner, Michael D. Leveritt, Olivia R. L. Wright

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Waiting time for cancer treatment and mental health among patients with newly diagnosed esophageal or gastric cancer: a nationwide cohort study

Huan Song, Fang Fang, Unnur Valdimarsdóttir, Donghao Lu, Therese M.-L. Andersson, Christina Hultman, Weimin Ye, Lars Lundell, Jan Johansson, Magnus Nilsson, Mats Lindblad

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Analysis of cellular and molecular antitumor effects upon inhibition of SATB1 in glioblastoma cells

Anja Frömberg, Michael Rabe, Henry Oppermann, Frank Gaunitz, Achim Aigner

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration

Khayal Al-Khayal, Ahmed Alafeefy, Mansoor-Ali Vaali-Mohammed, Amer Mahmood, Ahmed Zubaidi, Omar Al-Obeed, Zahid Khan, Maha Abdulla, Rehan Ahmad

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Which symptoms are linked to a delayed presentation among melanoma patients? A retrospective study

Sally Jane O’Shea, Zoe Rogers, Fiona Warburton, Amanda J. Ramirez, Julia A. Newton-Bishop, Lindsay J. L. Forbes

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Perioperative changes in osteopontin and TGFβ1 plasma levels and their prognostic impact for radiotherapy in head and neck cancer

Bülent Polat, Philipp Kaiser, Gisela Wohlleben, Thomas Gehrke, Agmal Scherzad, Matthias Scheich, Uwe Malzahn, Thomas Fischer, Dirk Vordermark, Michael Flentje

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Biopsy of breast cancer metastases: patient characteristics and survival

Shlomit Strulov Shachar, Tanya Mashiach, Georgeta Fried, Karen Drumea, Noa Shafran, Hyman B. Muss, Gil Bar-Sela

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic values of EORTC QLQ-C30 and QLQ-HCC18 index-scores in patients with hepatocellular carcinoma – clinical application of health-related quality-of-life data

Leung Li, Frankie KF Mo, Stephen L Chan, Edwin P Hui, Nelson SL Tang, Jane Koh, Linda KS Leung, Annette NY Poon, Joyce Hui, Cheuk M Chu, Kit F Lee, Brigette BY Ma, Paul BS Lai, Anthony TC Chan, Simon CH Yu, Winnie Yeo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma

Gabriela Gremel, Dijana Djureinovic, Marjut Niinivirta, Alexander Laird, Oscar Ljungqvist, Henrik Johannesson, Julia Bergman, Per-Henrik Edqvist, Sanjay Navani, Naila Khan, Tushar Patil, Åsa Sivertsson, Mathias Uhlén, David J. Harrison, Gustav J. Ullenhag, Grant D. Stewart, Fredrik Pontén

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Molecular chess? Hallmarks of anti-cancer drug resistance

Ian A. Cree, Peter Charlton

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

PGE2 promotes breast cancer-associated lymphangiogenesis by activation of EP4 receptor on lymphatic endothelial cells

Pinki Nandi, Gannareddy V. Girish, Mousumi Majumder, Xiping Xin, Elena Tutunea-Fatan, Peeyush K. Lala

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1

Messaouda Merzoug-Larabi, Caroline Spasojevic, Marianne Eymard, Caroline Hugonin, Christian Auclair, Manale Karam

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Solitary plasmacytoma: population-based analysis of survival trends and effect of various treatment modalities in the USA

Nishitha Thumallapally, Ahmed Meshref, Mohammed Mousa, Terenig Terjanian

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Expansion of the Milan criteria without any sacrifice: combination of the Hangzhou criteria with the pre-transplant platelet-to-lymphocyte ratio

Weiliang Xia, Qinghong Ke, Hua Guo, Weilin Wang, Min Zhang, Yan Shen, Jian Wu, Xiao Xu, Sheng Yan, Jun Yu, Mangli Zhang, Shusen Zheng

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

A case report of primary unilateral adrenal NK/T cell lymphoma: good clinical outcome with trimodality treatment

Liu Hu, Weimin Xu, Mingwei Wang, Pan Wang, Guang Han, Chi Lin

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Sorafenib versus sunitinib as first-line treatment agents in Chinese patients with metastatic renal cell carcinoma: the largest multicenter retrospective analysis of survival and prognostic factors

Hai-Liang Zhang, Xi-Nan Sheng, Xue-Song Li, Hong-Kai Wang, Zhi-Hong Chi, Zhi-Song He, Ding-Wei Ye, Jun Guo

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Case report: whole exome sequencing of primary cardiac angiosarcoma highlights potential for targeted therapies

Leah Zhrebker, Irene Cherni, Lara M. Gross, Margaret M. Hinshelwood, Merrick Reese, Jessica Aldrich, Joseph M. Guileyardo, William C. Roberts, David Craig, Daniel D. Von Hoff, Robert G. Mennel, John D. Carpten

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Therapeutic vaccine targeting Epstein-Barr virus latent protein, LMP1, suppresses LMP1-expressing tumor growth and metastasis in vivo

Mei-Chun Lin, Yong-Chong Lin, Syue-Ting Chen, Tai-Horng Young, Pei-Jen Lou

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Upregulation of Mrps18a in breast cancer identified by selecting phage antibody libraries on breast tissue sections

Karen Marie Juul Sørensen, Theresa Meldgaard, Connie Jenning Melchjorsen, Agla J. Fridriksdottir, Henrik Pedersen, Ole William Petersen, Peter Kristensen

01.12.2017 | Debate | Ausgabe 1/2017 Open Access

Growth, progression and chromosome instability of Neuroblastoma: a new scenario of tumorigenesis?

Gian Paolo Tonini

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Functional significance of CD105-positive cells in papillary renal cell carcinoma

Damian Matak, Klaudia K. Brodaczewska, Cezary Szczylik, Irena Koch, Adam Myszczyszyn, Monika Lipiec, Slawomir Lewicki, Lukasz Szymanski, Robert Zdanowski, Anna M. Czarnecka

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Lung adenocarcinoma expressing receptor for advanced glycation end-products with primary systemic AL amyloidosis: a case report and literature review

Shouichi Okamoto, Shinsaku Togo, Ichiro Nagata, Kazue Shimizu, Yoshika Koinuma, Yukiko Namba, Jun Ito, Toshimasa Uekusa, Kazuhisa Takahashi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Establishing a xenograft mouse model of peritoneal dissemination of gastric cancer with organ invasion and fibrosis

Mitsuyoshi Okazaki, Sachio Fushida, Shinichi Harada, Tomoya Tsukada, Jun Kinoshita, Katsunobu Oyama, Tomoharu Miyashita, Itasu Ninomiya, Tetsuo Ohta

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Association between telomere length and the risk of colorectal cancer: a meta-analysis of observational studies

Cho Naing, Kyan Aung, Pei Kuan Lai, Joon Wah Mak

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic relevance of lactate dehydrogenase in advanced pancreatic ductal adenocarcinoma patients

Yuanyuan Xiao, Wen Chen, Zhihui Xie, Zhenyi Shao, Hua Xie, Guoyou Qin, Naiqing Zhao

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Intraperitoneal cisplatin and doxorubicin as maintenance chemotherapy for unresectable ovarian cancer: a case report

Clemens B. Tempfer, Franziska Hartmann, Ziad Hilal, Günther A. Rezniczek

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Biological toxicities as surrogate markers of efficacy in patients treated with mTOR inhibitors for metastatic renal cell carcinoma

M. Jebali, R. Elaidi, M. Brizard, J. Fouque, C. Takouchop, B. Sabatier, S. Oudard, J. Medioni

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic significance of Ki67 in Chinese women diagnosed with ER+/HER2− breast cancers by the 2015 St. Gallen consensus classification

Yue Hu, Ran Gu, Jinghua Zhao, Yaping Yang, Fengtao Liu, Liang Jin, Kai Chen, Haixia Jia, Hongli Wang, Qiang Liu, Fengxi Su, Weijuan Jia

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Use of liquid biopsies to monitor disease progression in a sarcoma patient: a case report

Heidi M. Namløs, Olga Zaikova, Bodil Bjerkehagen, Daniel Vodák, Eivind Hovig, Ola Myklebost, Kjetil Boye, Leonardo A. Meza-Zepeda

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A matched-pair study comparing whole-brain irradiation alone to radiosurgery or fractionated stereotactic radiotherapy alone in patients irradiated for up to three brain metastases

Dirk Rades, Stefan Janssen, Liesa Dziggel, Oliver Blanck, Amira Bajrovic, Theo Veninga, Steven E. Schild

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Parity and bladder cancer risk: a dose-response meta-analysis

Yunjin Bai, Xiaoming Wang, Yubo Yang, Yin Tang, Jia Wang, Ping Han

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Differential long-term stability of microRNAs and RNU6B snRNA in 12–20 year old archived formalin-fixed paraffin-embedded specimens

Sarah B. Peskoe, John R. Barber, Qizhi Zheng, Alan K. Meeker, Angelo M. De Marzo, Elizabeth A. Platz, Shawn E. Lupold

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway

Kengo Kuroda, Tomokazu Fukuda, Marija Krstic-Demonacos, Constantinos Demonacos, Kazuhiko Okumura, Hiroshi Isogai, Miwa Hayashi, Kazuki Saito, Emiko Isogai

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells

Wenxing Chen, Yanhong Pan, Siliang Wang, Yuping Liu, Guangying Chen, Liang Zhou, Wenting Ni, Aiyun Wang, Yin Lu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Chemotherapy-induced Sinusoidal Injury (CSI) score: a novel histologic assessment of chemotherapy-related hepatic sinusoidal injury in patients with colorectal liver metastasis

Heather L. Stevenson, Mariana M. Prats, Eizaburo Sasatomi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Concordance between PIK3CA mutations in endoscopic biopsy and surgically resected specimens of esophageal squamous cell carcinoma

Ken Hatogai, Satoshi Fujii, Takashi Kojima, Hiroyuki Daiko, Toshihiko Doi, Atsushi Ohtsu, Atsushi Ochiai, Yuichi Takiguchi, Takayuki Yoshino

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Pancreatic neuroendocrine tumor with metastasis to the spleen: a case report

Yasunaru Sakuma, Yoshikazu Yasuda, Naohiro Sata, Yoshinori Hosoya, Atsushi Shimizu, Hirofumi Fujii, Daisuke Matsubara, Noriyuki Fukushima, Atsushi Miki, Misato Maeno, Alan Kawarai Lefor

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Retrospective study of RAS/PIK3CA/BRAF tumor mutations as predictors of response to first-line chemotherapy with bevacizumab in metastatic colorectal cancer patients

Izuma Nakayama, Eiji Shinozaki, Tomohiro Matsushima, Takeru Wakatsuki, Mariko Ogura, Takashi Ichimura, Masato Ozaka, Daisuke Takahari, Mitsukuni Suenaga, Keisho Chin, Nobuyuki Mizunuma, Kensei Yamaguchi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The acceleration of glucose accumulation in renal cell carcinoma assessed by FDG PET/CT demonstrated acquisition of resistance to tyrosine kinase inhibitor therapy

Noboru Nakaigawa, Keiichi Kondo, Daiki Ueno, Kazuhiro Namura, Kazuhide Makiyama, Kazuki Kobayashi, Koichi Shioi, Ichiro Ikeda, Takeshi Kishida, Tomohiro Kaneta, Ryogo Minamimoto, Ukihide Tateishi, Tomio Inoue, Masahiro Yao

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma

Xiaoyan Han, Lijuan Wang, Hongfei Shi, Gaofeng Zheng, Jingsong He, Wenjun Wu, Jimin Shi, Guoqing Wei, Weiyan Zheng, Jie Sun, He Huang, Zhen Cai

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Early life socioeconomic environment and mammographic breast density

Parisa Tehranifar, Barbara A. Cohn, Julie D. Flom, Angeline Protacio, Piera Cirillo, L. H. Lumey, Karin B. Michels, Mary Beth Terry

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The efficacy and roles of combining temozolomide with whole brain radiotherapy in protection neurocognitive function and improvement quality of life of non-small-cell lung cancer patients with brain metastases

Xia Deng, Zhen Zheng, Baochai Lin, Huafang Su, Hanbin Chen, Shaoran Fei, Zhenghua Fei, Lihao Zhao, Xiance Jin, Cong-Ying Xie

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Swallowing interventions for the treatment of dysphagia after head and neck cancer: a systematic review of behavioural strategies used to promote patient adherence to swallowing exercises

Roganie Govender, Christina H. Smith, Stuart A. Taylor, Helen Barratt, Benjamin Gardner

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer

Simone Brandt, Eleftherios P. Samartzis, Anne-Katrin Zimmermann, Daniel Fink, Holger Moch, Aurelia Noske, Konstantin J. Dedes

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The miR-34a-5p promotes the multi-chemoresistance of osteosarcoma via repression of the AGTR1 gene

Youguang Pu, Fangfang Zhao, Yinpeng Li, Mingda Cui, Haiyan Wang, Xianghui Meng, Shanbao Cai

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

MALAT1 promoted invasiveness of gastric adenocarcinoma

Na Keum Lee, Jung Hwa Lee, Cristina Ivan, Hui Ling, Xinna Zhang, Chan Hyuk Park, George A. Calin, Sang Kil Lee

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Incidence of solitary pulmonary nodules in Northeastern France: a population-based study in five regions

Émilie Marrer, Damien Jolly, Patrick Arveux, Catherine Lejeune, Marie-Christine Woronoff-Lemsi, Jérémie Jégu, Francis Guillemin, Michel Velten

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Topoisomerase I copy number alterations as biomarker for irinotecan efficacy in metastatic colorectal cancer

Jesper Andreas Palshof, Estrid Vilma Solyom Høgdall, Tim Svenstrup Poulsen, Dorte Linnemann, Benny Vittrup Jensen, Per Pfeiffer, Line Schmidt Tarpgaard, Nils Brünner, Jan Stenvang, Mette Yilmaz, Dorte Lisbet Nielsen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Evaluation of the cytotoxicity of the Bithionol - cisplatin combination in a panel of human ovarian cancer cell lines

Vijayalakshmi N. Ayyagari, Tsung-han Jeff Hsieh, Paula L. Diaz-Sylvester, Laurent Brard

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms

Marina Badenes, Alexandre Trindade, Hugo Pissarra, Luís Lopes-da-Costa, António Duarte

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer

Maria Laura Pati, John R. Hornick, Mauro Niso, Francesco Berardi, Dirk Spitzer, Carmen Abate, William Hawkins

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Genomic pathways modulated by Twist in breast cancer

Farhad Vesuna, Yehudit Bergman, Venu Raman

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Detection of circulating tumor cells with CK20 RT-PCR is an independent negative prognostic marker in colon cancer patients – a prospective study

Sebastian Hinz, Alexander Hendricks, Amke Wittig, Clemens Schafmayer, Jürgen Tepel, Holger Kalthoff, Thomas Becker, Christian Röder

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Narrow band imaging versus lugol chromoendoscopy to diagnose squamous cell carcinoma of the esophagus: a systematic review and meta-analysis

Flavio Hiroshi Ananias Morita, Wanderley Marques Bernardo, Edson Ide, Rodrigo Silva Paula Rocha, Julio Cesar Martins Aquino, Mauricio Kazuyoshi Minata, Kendi Yamazaki, Sergio Barbosa Marques, Paulo Sakai, Eduardo Guimarães Hourneaux de Moura

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Norcantharidin Inhibits cell growth by suppressing the expression and phosphorylation of both EGFR and c-Met in human colon cancer cells

Peiju Qiu, Siwen Wang, Ming Liu, He Ma, Xuan Zeng, Meng Zhang, Lingling Xu, Yidi Cui, Huixin Xu, Yang Tang, Yanli He, Lijuan Zhang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

D-dimer is an essential accompaniment of circulating tumor cells in gastric cancer

Dongmei Diao, Yao Cheng, Yongchun Song, Hao Zhang, Zhangjian Zhou, Chengxue Dang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Incidence of Venous Thromboembolism in cancer patients treated with Cisplatin based chemotherapy — a cohort study

Muhammad Nauman Zahir, Quratulain Shaikh, Munira Shabbir-Moosajee, Adnan Abdul Jabbar

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Microvascular invasion has limited clinical values in hepatocellular carcinoma patients at Barcelona Clinic Liver Cancer (BCLC) stages 0 or B

Cheng Huang, Xiao-Dong Zhu, Yuan Ji, Guang-Yu Ding, Guo-Ming Shi, Ying-Hao Shen, Jian Zhou, Jia Fan, Hui-Chuan Sun

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Risk factors for aspiration pneumonia after definitive chemoradiotherapy or bio-radiotherapy for locally advanced head and neck cancer: a monocentric case control study

Sadayuki Kawai, Tomoya Yokota, Yusuke Onozawa, Satoshi Hamauchi, Akira Fukutomi, Hirofumi Ogawa, Tsuyoshi Onoe, Tetsuro Onitsuka, Takashi Yurikusa, Akiko Todaka, Takahiro Tsushima, Yukio Yoshida, Yosuke Kito, Keita Mori, Hirofumi Yasui

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

High expression of micro RNA-135A in hepatocellular carcinoma is associated with recurrence within 12 months after resection

Johann von Felden, Denise Heim, Kornelius Schulze, Till Krech, Florian Ewald, Björn Nashan, Ansgar W. Lohse, Henning Wege

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Evaluation of the ablation margin of hepatocellular carcinoma using CEUS-CT/MR image fusion in a phantom model and in patients

Kai Li, Zhongzhen Su, Erjiao Xu, Qiannan Huang, Qingjing Zeng, Rongqin Zheng

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic histological factors in patients with esophageal squamous cell carcinoma after preoperative chemoradiation followed by surgery

Cheng-Che Tu, Po-Kuei Hsu, Ling-I Chien, Wan-Chen Liu, Chien-Sheng Huang, Chih-Cheng Hsieh, Han-Shui Hsu, Yu-Chung Wu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Genetic polymorphisms of SCN9A are associated with oxaliplatin-induced neuropathy

María Sereno, Gerardo Gutiérrez-Gutiérrez, Juan Moreno Rubio, María Apellániz-Ruiz, Lara Sánchez-Barroso, Enrique Casado, Sandra Falagan, Miriam López-Gómez, María Merino, César Gómez-Raposo, Nuria Rodriguez-Salas, Francisco Zambrana Tébar, Cristina Rodríguez-Antona

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Race and BMI modify associations of calcium and vitamin D intake with prostate cancer

Ken Batai, Adam B. Murphy, Maria Ruden, Jennifer Newsome, Ebony Shah, Michael A. Dixon, Elizabeth T. Jacobs, Courtney M. P. Hollowell, Chiledum Ahaghotu, Rick A. Kittles

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Stepwise addition of genetic changes correlated with histological change from “well-differentiated” to “sarcomatoid” phenotypes: a case report

Taichiro Goto, Yosuke Hirotsu, Hitoshi Mochizuki, Takahiro Nakagomi, Toshio Oyama, Kenji Amemiya, Masao Omata

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Tracking the origin of simultaneous endometrial and ovarian cancer by next-generation sequencing – a case report

Nadejda Valtcheva, Franziska M. Lang, Aurelia Noske, Eleftherios P. Samartzis, Anna-Maria Schmidt, Elisa Bellini, Daniel Fink, Holger Moch, Markus Rechsteiner, Konstantin J. Dedes, Peter J. Wild

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis

Sridhar Murahari, Aimee L. Jalkanen, Samuel K. Kulp, Ching-Shih Chen, Jaime F. Modiano, Cheryl A. London, William C. Kisseberth

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells

Shalini V. Rao, Guri Solum, Barbara Niederdorfer, Kristin G. Nørsett, Geir Bjørkøy, Liv Thommesen

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Low glycemic index diet, exercise and vitamin D to reduce breast cancer recurrence (DEDiCa): design of a clinical trial

Livia S.A. Augustin, Massimo Libra, Anna Crispo, Maria Grimaldi, Michele De Laurentiis, Massimo Rinaldo, Massimiliano D’Aiuto, Francesca Catalano, Giuseppe Banna, Francesco Ferrau’, Rosalba Rossello, Diego Serraino, Ettore Bidoli, Samuele Massarut, Guglielmo Thomas, Davide Gatti, Ernesta Cavalcanti, Monica Pinto, Gabriele Riccardi, Edward Vidgen, Cyril W.C. Kendall, David J.A. Jenkins, Gennaro Ciliberto, Maurizio Montella

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic value of CC-chemokine receptor seven expression in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitor

Yu Xia, Li Liu, Ying Xiong, Qi Bai, Jiajun Wang, Wei Xi, Yang Qu, Jiejie Xu, Jianming Guo

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy for prostate cancer

Wendy Demark-Wahnefried, Jeffery W. Nix, Gary R. Hunter, Soroush Rais-Bahrami, Renee A. Desmond, Balu Chacko, Casey D. Morrow, Maria Azrad, Andrew D. Frugé, Yuko Tsuruta, Travis Ptacek, Scott A. Tully, Roanne Segal, William E. Grizzle

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Primary neuroendocrine breast carcinomas are associated with poor local control despite favourable biological profile: a retrospective clinical study

Nelli Roininen, Sari Takala, Kirsi-Maria Haapasaari, Arja Jukkola-Vuorinen, Johanna Mattson, Päivi Heikkilä, Peeter Karihtala

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Neovascularization of hepatocellular carcinoma in a nude mouse orthotopic liver cancer model: a morphological study using X-ray in-line phase-contrast imaging

Beilei Li, Yiqiu Zhang, Weizhong Wu, Guohao Du, Liang Cai, Hongcheng Shi, Shaoliang Chen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

An increase in physical activity after colorectal cancer surgery is associated with improved recovery of physical functioning: a prospective cohort study

Moniek van Zutphen, Renate M. Winkels, Fränzel J. B. van Duijnhoven, Suzanne A. van Harten-Gerritsen, Dieuwertje E. G. Kok, Peter van Duijvendijk, Henk K. van Halteren, Bibi M. E. Hansson, Flip M. Kruyt, Ernst J. Spillenaar Bilgen, Johannes H. W. de Wilt, Jaap J. Dronkers, Ellen Kampman

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The feasibility and advantage of uniportal video-assisted thoracoscopic surgery (VATS) in pulmonary lobectomy

Linlin Wang, Dabei Liu, Jibin Lu, Suning Zhang, Xueying Yang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Upregulation of the proto-oncogene Bmi-1 predicts a poor prognosis in pediatric acute lymphoblastic leukemia

Hong-Xia Peng, Xiao-Dan Liu, Zi-Yan Luo, Xiao-Hong Zhang, Xue-Qun Luo, Xiao Chen, Hua Jiang, Ling Xu

01.12.2017 | Research Article | Ausgabe 1/2017 Open Access

An approach to forecast human cancer by profiling microRNA expressions from NGS data

A. Salim, R. Amjesh, S. S. Vinod Chandra

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Lung cells support osteosarcoma cell migration and survival

Shibing Yu, Mitchell Stephen Fourman, Adel Mahjoub, Jonathan Brendan Mandell, Jared Anthony Crasto, Nicholas Giuseppe Greco, Kurt Richard Weiss

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A non-invasive tool for detecting cervical cancer odor by trained scent dogs

Héctor Guerrero-Flores, Teresa Apresa-García, Ónix Garay-Villar, Alejandro Sánchez-Pérez, David Flores-Villegas, Artfy Bandera-Calderón, Raúl García-Palacios, Teresita Rojas-Sánchez, Pablo Romero-Morelos, Verónica Sánchez-Albor, Osvaldo Mata, Víctor Arana-Conejo, Jesús Badillo-Romero, Keiko Taniguchi, Daniel Marrero-Rodríguez, Mónica Mendoza-Rodríguez, Miriam Rodríguez-Esquivel, Víctor Huerta-Padilla, Andrea Martínez-Castillo, Irma Hernández-Gallardo, Ricardo López-Romero, Cindy Bandala, Juan Rosales-Guevara, Mauricio Salcedo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Adjuvant radiotherapy improves cause specific survival in stage II, not stage III mucinous carcinoma of the rectum

Qingguo Li, Yaqi Li, Weixing Dai, Sheng Wang, Ye Xu, Xinxiang Li, Sanjun Cai

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Study protocol of the TIRED study: a randomised controlled trial comparing either graded exercise therapy for severe fatigue or cognitive behaviour therapy with usual care in patients with incurable cancer

Hanneke Poort, Constans A. H. H. V. M. Verhagen, Marlies E. W. J. Peters, Martine M. Goedendorp, A. Rogier T. Donders, Maria T. E. Hopman, Maria W. G. Nijhuis-van der Sanden, Thea Berends, Gijs Bleijenberg, Hans Knoop

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Life situation and psychosocial care of adolescent and young adult (AYA) cancer patients – study protocol of a 12-month prospective longitudinal study

Katja Leuteritz, Michael Friedrich, Erik Nowe, Annekathrin Sender, Yve Stöbel-Richter, Kristina Geue

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

The Norwegian dietary guidelines and colorectal cancer survival (CRC-NORDIET) study: a food-based multicentre randomized controlled trial

Hege Berg Henriksen, Hanna Ræder, Siv Kjølsrud Bøhn, Ingvild Paur, Ane Sørlie Kværner, Siv Åshild Billington, Morten Tandberg Eriksen, Gro Wiedsvang, Iris Erlund, Arne Færden, Marit Bragelien Veierød, Manuela Zucknick, Sigbjørn Smeland, Rune Blomhoff

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Mammographic breast density and risk of breast cancer in women with atypical hyperplasia: an observational cohort study from the Mayo Clinic Benign Breast Disease (BBD) cohort

Robert A. Vierkant, Amy C. Degnim, Derek C. Radisky, Daniel W. Visscher, Ethan P. Heinzen, Ryan D. Frank, Stacey J. Winham, Marlene H. Frost, Christopher G. Scott, Matthew R. Jensen, Karthik Ghosh, Armando Manduca, Kathleen R. Brandt, Dana H. Whaley, Lynn C. Hartmann, Celine M. Vachon

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cancers of unknown primary diagnosed during hospitalization: a population-based study

William Jones, Gwen Allardice, Iona Scott, Karin Oien, David Brewster, David S. Morrison

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation

Martin McLaughlin, Holly E. Barker, Aadil A. Khan, Malin Pedersen, Magnus Dillon, David C. Mansfield, Radhika Patel, Joan N. Kyula, Shreerang A. Bhide, Kate L. Newbold, Christopher M. Nutting, Kevin J. Harrington

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma

Hoon Hur, In-Hye Ham, Dakeun Lee, Hyejin Jin, Kristina Y. Aguilera, Hye Jeong Oh, Sang-Uk Han, Ji Eun Kwon, Young-Bae Kim, Ke Ding, Rolf A. Brekken

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo

Nicole Lavender, Jinming Yang, Sheau-Chiann Chen, Jiqing Sai, C. Andrew Johnson, Philip Owens, Gregory D. Ayers, Ann Richmond

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: a first-in-human phase-I study

Shingo Miyamoto, Fusanori Yotsumoto, Taeko Ueda, Tatsuya Fukami, Ayako Sanui, Kohei Miyata, Sung Ouk Nam, Satoshi Fukagawa, Takahiro Katsuta, Miyako Maehara, Haruhiko Kondo, Daisuke Miyahara, Kyoko Shirota, Toshiyuki Yoshizato, Masahide Kuroki, Hiroaki Nishikawa, Keijiro Saku, Yoshio Tsuboi, Kenji Ishitsuka, Yasushi Takamatsu, Kazuo Tamura, Akira Matsunaga, Toru Hachisuga, Shinsuke Nishino, Takashi Odawara, Kazuhiro Maeda, Sadao Manabe, Toyokazu Ishikawa, Yoshinobu Okuno, Minako Ohishi, Tomoya Hikita, Hiroto Mizushima, Ryo Iwamoto, Eisuke Mekada

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Higher IGFBP-1 to IGF-1 serum ratio predicts unfavourable survival in patients with nasopharyngeal carcinoma

Xinwei Feng, Jianhua Lin, Shan Xing, Wanli Liu, Ge Zhang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Nomogram prediction of individual prognosis of patients with hepatocellular carcinoma

Gang Wan, Fangyuan Gao, Jialiang Chen, Yuxin Li, Mingfan Geng, Le Sun, Yao Liu, Huimin Liu, Xue Yang, Rui Wang, Ying Feng, Xianbo Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Distinct prostate cancer-related mRNA cargo in extracellular vesicle subsets from prostate cell lines

Elisa Lázaro-Ibáñez, Taral R. Lunavat, Su Chul Jang, Carmen Escobedo-Lucea, Jorge Oliver-De La Cruz, Pia Siljander, Jan Lötvall, Marjo Yliperttula

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells

Sergey A. Dyshlovoy, Ramin Madanchi, Jessica Hauschild, Katharina Otte, Winfried H. Alsdorf, Udo Schumacher, Vladimir I. Kalinin, Alexandra S. Silchenko, Sergey A. Avilov, Friedemann Honecker, Valentin A. Stonik, Carsten Bokemeyer, Gunhild von Amsberg

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cancer mortality in former East and West Germany: a story of unification?

Daniel Medenwald, Dirk Vordermark, Christian T. Dietzel

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A systematic review of geographical differences in management and outcomes for colorectal cancer in Australia

Michael J. Ireland, Sonja March, Fiona Crawford-Williams, Mandy Cassimatis, Joanne F. Aitken, Melissa K. Hyde, Suzanne K. Chambers, Jiandong Sun, Jeff Dunn

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The important role of circulating CYFRA21-1 in metastasis diagnosis and prognostic value compared with carcinoembryonic antigen and neuron-specific enolase in lung cancer patients

Li Zhang, Dan Liu, Lei Li, Dan Pu, Ping Zhou, Yuting Jing, He Yu, Yanwen Wang, Yihan Zhu, Yanqi He, Yalun Li, Shuang Zhao, Zhixin Qiu, Weimin Li

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk

Liv B. Gansmo, Merete Bjørnslett, Mari Kyllesø Halle, Helga B. Salvesen, Pål Romundstad, Kristian Hveem, Lars Vatten, Anne Dørum, Per E. Lønning, Stian Knappskog

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

The Women’s wellness after cancer program: a multisite, single-blinded, randomised controlled trial protocol

Debra Anderson, Charrlotte Seib, Dian Tjondronegoro, Jane Turner, Leanne Monterosso, Amanda McGuire, Janine Porter-Steele, Wei Song, Patsy Yates, Neil King, Leonie Young, Kate White, Kathryn Lee, Sonj Hall, Mei Krishnasamy, Kathy Wells, Sarah Balaam, Alexandra L. McCarthy

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species

Zachary C. Gersey, Gregor A. Rodriguez, Eric Barbarite, Anthony Sanchez, Winston M. Walters, Kelechi C. Ohaeto, Ricardo J. Komotar, Regina M. Graham

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Optitrain: a randomised controlled exercise trial for women with breast cancer undergoing chemotherapy

Y. Wengström, K. A. Bolam, S. Mijwel, C. J. Sundberg, M. Backman, M. Browall, J. Norrbom, H. Rundqvist

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Body mass index modifies the relationship between γ-H2AX, a DNA damage biomarker, and pathological complete response in triple-negative breast cancer

Maddalena Barba, Patrizia Vici, Laura Pizzuti, Luigi Di Lauro, Domenico Sergi, Anna Di Benedetto, Cristiana Ercolani, Francesca Sperati, Irene Terrenato, Claudio Botti, Lucia Mentuccia, Laura Iezzi, Teresa Gamucci, Clara Natoli, Ilio Vitale, Marcella Mottolese, Ruggero De Maria, Marcello Maugeri-Saccà

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Stromal alterations in ovarian cancers via wavelength dependent Second Harmonic Generation microscopy and optical scattering

Karissa B. Tilbury, Kirby R. Campbell, Kevin W. Eliceiri, Sana M. Salih, Manish Patankar, Paul J. Campagnola

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Implementing exercise in cancer care: study protocol to evaluate a community-based exercise program for people with cancer

Prue Cormie, Stephanie Lamb, Robert U. Newton, Lani Valentine, Sandy McKiernan, Nigel Spry, David Joseph, Dennis R. Taaffe, Christopher M. Doran, Daniel A. Galvão

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Microparticles shed from multidrug resistant breast cancer cells provide a parallel survival pathway through immune evasion

Ritu Jaiswal, Michael S. Johnson, Deep Pokharel, S. Rajeev Krishnan, Mary Bebawy

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

CLASP2 is involved in the EMT and early progression after transurethral resection of the bladder tumor

Bisong Zhu, Lin Qi, Sulai Liu, Wentao Liu, Zhenyu Ou, Minfeng Chen, Longfei Liu, Xiongbing Zu, Jun Wang, Yuan Li

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Improving adherence to colorectal cancer surveillance guidelines: results of a randomised controlled trial

Mariko Carey, Robert Sanson-Fisher, Finlay Macrae, Emilie Cameron, David Hill, Catherine D’Este, Christopher Doran

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Mechanism of action of trabectedin in desmoplastic small round cell tumor cells

S. Uboldi, I. Craparotta, G. Colella, E. Ronchetti, L. Beltrame, S. Vicario, S. Marchini, N. Panini, G. Dagrada, F. Bozzi, S. Pilotti, C. M. Galmarini, M. D’Incalci, R. Gatta

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts

Lina Leiss, Ercan Mutlu, Anne Øyan, Tao Yan, Oleg Tsinkalovsky, Linda Sleire, Kjell Petersen, Mohummad Aminur Rahman, Mireille Johannessen, Sidhartha S. Mitra, Hege K. Jacobsen, Krishna M. Talasila, Hrvoje Miletic, Inge Jonassen, Xingang Li, Nicolaas H. Brons, Karl-Henning Kalland, Jian Wang, Per Øyvind Enger

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

microRNA-29c inhibits cell proliferation by targeting NASP in human gastric cancer

Beiqin Yu, Xuehua Chen, Jianfang Li, Qinlong Gu, Zhenggang Zhu, Chen Li, Liping Su, Bingya Liu

01.12.2017 | Correspondence | Ausgabe 1/2017 Open Access

Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial

M. M. Koeneman, A. J. Kruse, L. F. S. Kooreman, A. zur Hausen, A. H. N. Hopman, S. J. S. Sep, T. Van Gorp, B. F. M. Slangen, H. J. van Beekhuizen, A. J. M. van de Sande, C. G. Gerestein, H. W. Nijman, R. F. P. M. Kruitwagen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Treatment patterns and survival in an exhaustive French cohort of pazopanib-eligible patients with metastatic soft tissue sarcoma (STS)

Isabelle Ray-Coquard, Olivier Collard, Françoise Ducimetiere, Mathieu Laramas, Florence Mercier, Nadine Ladarre, Stephanie Manson, Bertrand Tehard, Sébastien Clippe, Jean-Philippe Suchaud, Laetitia Stefani, Jean-Yves Blay

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Colorectal cancer surveillance in Hodgkin lymphoma survivors at increased risk of therapy-related colorectal cancer: study design

Lisanne S. Rigter, Manon C. W. Spaander, Leon M. Moons, Tanya M. Bisseling, Berthe M. P. Aleman, Jan Paul de Boer, Pieternella J. Lugtenburg, Cecile P. M. Janus, Eefke J. Petersen, Judith M. Roesink, John M. M. Raemaekers, Richard W. M. van der Maazen, Annemieke Cats, Eveline M. A. Bleiker, Petur Snaebjornsson, Beatriz Carvalho, Iris Lansdorp-Vogelaar, Katarzyna Jóźwiak, Hein te Riele, Gerrit A. Meijer, Flora E. van Leeuwen, Monique E. van Leerdam

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer

Cong Lin, Christof J. Majoor, Joris J. T. H. Roelofs, Martijn D. de Kruif, Hugo M. Horlings, Keren Borensztajn, C. Arnold Spek

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Thyroid fine-needle aspiration biopsy positively correlates with increased diagnosis of thyroid cancer in South Korean patients

Yoon Jae Cho, Do Young Kim, Eun-Cheol Park, Kyu-Tae Han

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Immunohistochemical determination of estrogen and progesterone receptors in breast cancer: relationship with clinicopathologic factors in 302 patients in Ivory Coast

Ahoua Benjamin Effi, Nguiessan Alphonse Aman, Baumaney Sylvanus Koui, Kouadio Donatien Koffi, Zie Cheick Traoré, Mohamed Kouyate

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Molecular stool testing as an alternative for surveillance colonoscopy: a cross-sectional cohort study

Meta C. J. van Lanschot, Beatriz Carvalho, Veerle M. H. Coupé, Manon van Engeland, Evelien Dekker, Gerrit A. Meijer

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Low CCL17 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma

Ying Xiong, Li Liu, Yu Xia, Jiajun Wang, Wei Xi, Qi Bai, Yang Qu, Jiejie Xu, Jianming Guo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Enhanced and long term immunogenicity of a Her-2/neu multi-epitope vaccine conjugated to the carrier CRM197 in conjunction with the adjuvant Montanide

Joshua Tobias, Joanna Jasinska, Karin Baier, Michael Kundi, Nicholas Ede, Christoph Zielinski, Ursula Wiedermann

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Case report: rapid and durable response to PDGFR targeted therapy in a child with refractory multiple infantile myofibromatosis and a heterozygous germline mutation of the PDGFRB gene

Peter Mudry, Ondrej Slaby, Jakub Neradil, Jana Soukalova, Kristyna Melicharkova, Ondrej Rohleder, Marta Jezova, Anna Seehofnerova, Elleni Michu, Renata Veselska, Jaroslav Sterba

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Meta-analysis of gene expression in relapsed childhood B-acute lymphoblastic leukemia

Yock-Ping Chow, Hamidah Alias, Rahman Jamal

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Inhibition of glioblastoma dispersal by the MEK inhibitor PD0325901

Stephen Shannon, Dongxuan Jia, Ildiko Entersz, Paul Beelen, Miao Yu, Christian Carcione, Jonathan Carcione, Aria Mahtabfar, Connan Vaca, Michael Weaver, David Shreiber, Jeffrey D. Zahn, Liping Liu, Hao Lin, Ramsey A. Foty

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Supporting adherence to oral anticancer agents: clinical practice and clues to improve care provided by physicians, nurse practitioners, nurses and pharmacists

Lonneke Timmers, Christel C. L. M. Boons, Mathieu Verbrugghe, Bart J. F. van den Bemt, Ann Van Hecke, Jacqueline G. Hugtenburg

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Photodynamic therapy combined to cisplatin potentiates cell death responses of cervical cancer cells

Laura Marise de Freitas, Rodolfo Bortolozo Serafim, Juliana Ferreira de Sousa, Thaís Fernanda Moreira, Cláudia Tavares dos Santos, Amanda Martins Baviera, Valeria Valente, Christiane Pienna Soares, Carla Raquel Fontana

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Comparison of immunohistochemistry with PCR for assessment of ER, PR, and Ki-67 and prediction of pathological complete response in breast cancer

Hans-Peter Sinn, Andreas Schneeweiss, Marius Keller, Kornelia Schlombs, Mark Laible, Julia Seitz, Sotirios Lakis, Elke Veltrup, Peter Altevogt, Sebastian Eidt, Ralph M. Wirtz, Frederik Marmé

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Adipokines, insulin resistance, and adiposity as a predictors of metabolic syndrome in child survivors of lymphoma and acute lymphoblastic leukemia of a developing country

Lourdes Barbosa-Cortés, Mardia López-Alarcón, Juan Manuel Mejía-Aranguré, Miguel Klünder-Klünder, María del Carmen Rodríguez-Zepeda, Hugo Rivera-Márquez, Alan de la Vega-Martínez, Jorge Martin-Trejo, Juan Shum-Luis, Karina Solis-Labastida, Enrique López-Aguilar, Guadalupe Matute-González, Roberto Bernaldez-Rios

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Enhanced expression of Vastatin inhibits angiogenesis and prolongs survival in murine orthotopic glioblastoma model

Yi Li, Jun Li, Yat Ming Woo, Zan Shen, Hong Yao, Yijun Cai, Marie Chia-mi Lin, Wai Sang Poon

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case report comprehensive genomic study of two cranial meningiomas with vastly different clinical presentation

Ramita Dewan, Alexander Pemov, Amalia S. Dutra, Evgenia D. Pak, Nancy A. Edwards, Abhik Ray-Chaudhury, Nancy F. Hansen, Settara C. Chandrasekharappa, James C. Mullikin, Ashok R. Asthagiri, John D. Heiss, Douglas R. Stewart, Anand V. Germanwala, NISC Comparative Sequencing Program

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement

Nicola Lehners, Isabelle Krämer, Maral Saadati, Axel Benner, Anthony D. Ho, Mathias Witzens-Harig

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy

Jessica Pahle, Lutz Menzel, Nicole Niesler, Dennis Kobelt, Jutta Aumann, Maria Rivera, Wolfgang Walther

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The clinical picture of cachexia: a mosaic of different parameters (experience of 503 patients)

S. Schwarz, O. Prokopchuk, K. Esefeld, S. Gröschel, J. Bachmann, S. Lorenzen, H. Friess, M. Halle, M. E. Martignoni

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Clinicopathologic characteristics and prognostic factors for primary spinal epidural lymphoma: report on 36 Chinese patients and review of the literature

Le Xiong, Ling-Min Liao, Jian-Wu Ding, Zhi-Lin Zhang, An-Wen Liu, Long Huang

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Rechallenge and maintenance therapy using cetuximab and chemotherapy administered to a patient with metastatic colorectal cancer

Jian Ma, Quan-liang Yang, Yang Ling

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer

Ivonne Lozano-Pope, Arnika Sharma, Michael Matthias, Kelly S. Doran, Marygorret Obonyo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Safety and efficacy of lobaplatin combined with 5-fluorouracil as first-line induction chemotherapy followed by lobaplatin-radiotherapy in locally advanced nasopharyngeal carcinoma: preliminary results of a prospective phase II trial

Liang-Ru Ke, Wei-Xiong Xia, Wen-Ze Qiu, Xin-Jun Huang, Jing Yang, Ya-Hui Yu, Hu Liang, Guo-Ying Liu, Yan-Fang Ye, Yan-Qun Xiang, Xiang Guo, Xing Lv

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

CD73 promotes proliferation and migration of human cervical cancer cells independent of its enzyme activity

Zhao-wei Gao, Hui-ping Wang, Fang Lin, Xi Wang, Min Long, Hui-zhong Zhang, Ke Dong

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Viral E6 is overexpressed via high viral load in invasive cervical cancer with episomal HPV16

Die Hong, Jia Liu, Ying Hu, Xiaonan Lu, Baohua Li, Yang Li, Dongxiao Hu, Weiguo Lu, Xing Xie, Xiaodong Cheng

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A phase II study to evaluate LY2603618 in combination with gemcitabine in pancreatic cancer patients

Berta Laquente, Jose Lopez-Martin, Donald Richards, Gerald Illerhaus, David Z. Chang, George Kim, Philip Stella, Dirk Richel, Cezary Szcylik, Stefano Cascinu, G. L. Frassineti, Tudor Ciuleanu, Karla Hurt, Scott Hynes, Ji Lin, Aimee Bence Lin, Daniel Von Hoff, Emiliano Calvo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J

Lin Shi, Zhaozhong Xu, Gang Wu, Xiaoting Chen, Yuanyuan Huang, Yanjing Wang, Weiqiang Jiang, Bin Ke

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Clinical performance evaluation of a sensitive, rapid low-throughput test for KRAS mutation analysis using formalin-fixed, paraffin-embedded tissue samples

Christine Weyn, Sofie Van Raemdonck, Robina Dendooven, Vincent Maes, Karen Zwaenepoel, Suzan Lambin, Patrick Pauwels

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

miR-296 inhibits the metastasis and epithelial-mesenchymal transition of colorectal cancer by targeting S100A4

Zheng He, Lianhua Yu, Shiyi Luo, Mingzhen Li, Junbo Li, Qi Li, Yi Sun, Chengbin Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Relationships between longitudinal neutrophil to lymphocyte ratios, body weight changes, and overall survival in patients with non-small cell lung cancer

B. A. Derman, J. N. Macklis, M. S. Azeem, S. Sayidine, S. Basu, M. Batus, F. Esmail, J. A. Borgia, P. Bonomi, M. J. Fidler

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Papillary thyroid microcarcinoma: the significance of high risk features

Nori L. Bradley, Sam M. Wiseman

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Myopericytoma occurrence in the liver and stomach space: imaging performance

Zhihua Chen, Wenjie Liang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Lower blood pressure and risk of cisplatin nephrotoxicity: a retrospective cohort study

Kazumi Komaki, Tetsuro Kusaba, Mai Tanaka, Hiroshi Kado, Yayoi Shiotsu, Masahiro Matsui, Atsushi Shiozaki, Hiroshi Nakano, Takeshi Ishikawa, Hitoshi Fujiwara, Hideyuki Konishi, Yoshito Itoh, Satoaki Matoba, Keiichi Tamagaki

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B

Caroline M. McKinnon, Harry Mellor

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree

Lorena Fernández-Martínez, José Antonio Villegas, Íñigo Santamaría, Ana S. Pitiot, Marta G. Alvarado, Soledad Fernández, Héctor Torres, Ángeles Paredes, Pilar Blay, Milagros Balbín

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway

Xue Wu, Ping Liu, Haijun Zhang, Yuan Li, Jumah Masoud Mohammad Salmani, Fei Wang, Ke Yang, Rong Fu, Zhewei Chen, Baoan Chen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

WD-repeat protein WDR13 is a novel transcriptional regulator of c-Jun and modulates intestinal homeostasis in mice

Vijay Pratap Singh, Saritha Katta, Satish Kumar

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Characterization of BRCA1 and BRCA2 variants in multi-ethnic Asian cohort from a Malaysian case-control study

Kah Nyin Lai, Weang Kee Ho, In Nee Kang, Peter Choon Eng Kang, Sze Yee Phuah, Shivaani Mariapun, Cheng-Har Yip, Nur Aishah Mohd Taib, Soo-Hwang Teo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Validation of an NGS mutation detection panel for melanoma

Anne Reiman, Hugh Kikuchi, Daniela Scocchia, Peter Smith, Yee Wah Tsang, David Snead, Ian A Cree

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

High-dose chemotherapy and autologous stem cell transplantation of patients with multiple myeloma in an outpatient setting

Katharina Lisenko, Sandra Sauer, Thomas Bruckner, Gerlinde Egerer, Hartmut Goldschmidt, Jens Hillengass, Johann W. Schmier, Sofia Shah, Mathias Witzens-Harig, Anthony D. Ho, Patrick Wuchter

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Cardiac metastasis from colon cancer effectively treated with 5-fluorouracil, leucovorin, and oxaliplatin (modified FOLFOX6) plus panitumumab: a case report

Yoshiki Tsujii, Yoshito Hayashi, Akira Maekawa, Tetsuji Fujinaga, Kengo Nagai, Shunsuke Yoshii, Akihiko Sakatani, Satoshi Hiyama, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The effects of exercise on pain, fatigue, insomnia, and health perceptions in patients with operable advanced stage rectal cancer prior to surgery: a pilot trial

Jennifer Brunet, Shaunna Burke, Michael P.W. Grocott, Malcolm A. West, Sandy Jack

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Early evaluation of sunitinib for the treatment of advanced gastroenteropancreatic neuroendocrine neoplasms via CT imaging: RECIST 1.1 or Choi Criteria?

Yanji Luo, Jie Chen, Kun Huang, Yuan Lin, Minhu Chen, Ling Xu, Zi-Ping Li, Shi-Ting Feng

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Do pre-diagnosis primary care consultation patterns explain deprivation-specific differences in net survival among women with breast cancer? An examination of individually-linked data from the UK West Midlands cancer registry, national screening programme and Clinical Practice Research Datalink

M. Morris, L. M. Woods, K. Bhaskaran, B. Rachet

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma

Reza Bayat Mokhtari, Narges Baluch, Micky Ka Hon Tsui, Sushil Kumar, Tina S. Homayouni, Karen Aitken, Bikul Das, Sylvain Baruchel, Herman Yeger

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer

Martin Chevrier, Diwakar Bobbala, Alberto Villalobos-Hernandez, Md Gulam Musawwir Khan, Sheela Ramanathan, Caroline Saucier, Gerardo Ferbeyre, Sameh Geha, Subburaj Ilangumaran

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Testis specific Y-like 5: gene expression, methylation and implications for drug sensitivity in prostate carcinoma

Senthil R. Kumar, Jeffrey N. Bryan, Magda Esebua, James Amos-Landgraf, Tanner J. May

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Life tables for global surveillance of cancer survival (the CONCORD programme): data sources and methods

Devon Spika, Finian Bannon, Audrey Bonaventure, Laura M Woods, Rhea Harewood, Helena Carreira, Michel P Coleman, Claudia Allemani

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Expression of enhancer of zeste homolog 2 correlates with survival outcome in patients with metastatic breast cancer: exploratory study using primary and paired metastatic lesions

Hitoshi Inari, Nobuyasu Suganuma, Kae Kawachi, Tatsuya Yoshida, Takashi Yamanaka, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Hirotaka Nakayama, Ayumi Yamanaka, Katsuhiko Masudo, Takashi Oshima, Tomoyuki Yokose, Yasushi Rino, Satoru Shimizu, Yohei Miyagi, Munetaka Masuda

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Metallothionein 1H (MT1H) functions as a tumor suppressor in hepatocellular carcinoma through regulating Wnt/β-catenin signaling pathway

Yulong Zheng, Lihua Jiang, Yongxian Hu, Cheng Xiao, Nong Xu, Jianying Zhou, Xinhui Zhou

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

In search of druggable targets for GBM amino acid metabolism

Eduard H. Panosyan, Henry J. Lin, Jan Koster, Joseph L. Lasky III

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The prognostic utility of the transcription factor SRF in docetaxel-resistant prostate cancer: in-vitro discovery and in-vivo validation

D. J. Lundon, A. Boland, M. Prencipe, G. Hurley, A O’Neill, E. Kay, S. T. Aherne, P. Doolan, S. F. Madden, M. Clynes, C. Morrissey, J. M. Fitzpatrick, R. W. Watson

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis

Joyce Y. Cheng, Taylor C. Brown, Timothy D. Murtha, Adam Stenman, C. Christofer Juhlin, Catharina Larsson, James M. Healy, Manju L. Prasad, Wolfram T. Knoefel, Andreas Krieg, Ute I. Scholl, Reju Korah, Tobias Carling

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cancer-related health behaviours of young people not in education, employment or training (‘NEET’): a cross-sectional study

Catherine H. Stewart, Philip Berry, Dunja Przulj, Charlene Treanor

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Impact of a combined multimodal-aerobic and multimodal intervention compared to standard aerobic treatment in breast cancer survivors with chronic cancer-related fatigue - results of a three-armed pragmatic trial in a comprehensive cohort design

Matthias Kröz, Marcus Reif, Augustina Glinz, Bettina Berger, Andreas Nikolaou, Roland Zerm, Benno Brinkhaus, Matthias Girke, Arndt Büssing, Christoph Gutenbrunner, On behalf of the CRF-2 study group

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis

Jian-Zhong Wang, Jing-Jun Xiang, Li-Ge Wu, Yan-Sen Bai, Zhuo-Wang Chen, Xiang-Qian Yin, Qing Wang, Wen-Hao Guo, Ying Peng, Huan Guo, Ping Xu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Access to principal treatment centres and survival rates for children and young people with cancer in Yorkshire, UK

Lesley Fairley, Daniel P. Stark, Daniel Yeomanson, Sally E. Kinsey, Adam W. Glaser, Susan V. Picton, Linda Evans, Richard G. Feltbower

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Altering calcium influx for selective destruction of breast tumor

Han-Gang Yu, Sarah McLaughlin, Mackenzie Newman, Kathleen Brundage, Amanda Ammer, Karen Martin, James Coad

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene

Floriana Forzati, Marco De Martino, Francesco Esposito, Romina Sepe, Simona Pellecchia, Umberto Malapelle, Gianluca Pellino, Claudio Arra, Alfredo Fusco

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The C-reactive protein/albumin ratio, a validated prognostic score, predicts outcome of surgical renal cell carcinoma patients

Shengjie Guo, Xiaobo He, Qian Chen, Guangwei Yang, Kai Yao, Pei Dong, Yunlin Ye, Dong Chen, Zhiling Zhang, Zike Qin, Zhuowei Liu, Yunfei Xue, Meng Zhang, Ruiwu Liu, Fangjian Zhou, Hui Han

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prevention of liver tumor formation in woodchucks with established hepatocellular carcinoma by treatment with cationic liposome-DNA complexes

Jeffery Fairman, Katherine H. Liu, Stephan Menne

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A phase I dose-escalation study of selumetinib in combination with docetaxel or dacarbazine in patients with advanced solid tumors

Patricia M. LoRusso, Jeffrey R. Infante, Kevin B. Kim, Howard A. Burris III, Gregory Curt, Ugochi Emeribe, Delyth Clemett, Helen K. Tomkinson, Roger B. Cohen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Is cancer a pure growth curve or does it follow a kinetics of dynamical structural transformation?

Maraelys Morales González, Javier Antonio González Joa, Luis Enrique Bergues Cabrales, Ana Elisa Bergues Pupo, Baruch Schneider, Suleyman Kondakci, Héctor Manuel Camué Ciria, Juan Bory Reyes, Manuel Verdecia Jarque, Miguel Angel O’Farril Mateus, Tamara Rubio González, Soraida Candida Acosta Brooks, José Luis Hernández Cáceres, Gustavo Victoriano Sierra González

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

miR-124 targets GATA6 to suppress cholangiocarcinoma cell invasion and metastasis

Feng Tian, Jian Chen, Shuguo Zheng, Dajiang Li, Xin Zhao, Peng Jiang, Jianwei Li, Shuguang Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

MEIS1 inhibits clear cell renal cell carcinoma cells proliferation and in vitro invasion or migration

Jie Zhu, Liang Cui, Axiang Xu, Xiaotao Yin, Fanglong Li, Jiangping Gao

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The effects of 1,4-dimethylpyridine in metastatic prostate cancer in mice

Agnieszka Denslow, Marta Switalska, Marcin Nowak, Magdalena Maciejewska, Stefan Chlopicki, Andrzej Marcinek, Jerzy Gebicki, Joanna Wietrzyk

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Effects of the lysosomal destabilizing drug siramesine on glioblastoma in vitro and in vivo

Stine S. Jensen, Stine A. Petterson, Bo Halle, Charlotte Aaberg-Jessen, Bjarne W. Kristensen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5

Linjie Chen, Dennis W. Wolff, Yan Xie, Ming-Fong Lin, Yaping Tu

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Stereotactic prostate adaptive radiotherapy utilising kilovoltage intrafraction monitoring: the TROG 15.01 SPARK trial

Paul Keall, Doan Trang Nguyen, Ricky O’Brien, Jeremy Booth, Peter Greer, Per Poulsen, Val Gebski, Andrew Kneebone, Jarad Martin

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Redefining radiotherapy for early-stage breast cancer with single dose ablative treatment: a study protocol

R. K. Charaghvandi, B. van Asselen, M. E. P. Philippens, H. M. Verkooijen, C. H. van Gils, P. J. van Diest, R. M. Pijnappel, M. G. G. Hobbelink, A. J. Witkamp, T. van Dalen, E. van der Wall, T. C. van Heijst, R. Koelemij, M. van Vulpen, H. J. G. D. van den Bongard

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Patients with pathological stage N2 rectal cancer treated with early adjuvant chemotherapy have a lower treatment failure rate

Yan-Ru Feng, Jing Jin, Hua Ren, Xin Wang, Shu-Lian Wang, Wei-Hu Wang, Yong-Wen Song, Yue-Ping Liu, Yuan Tang, Ning Li, Xin-Fan Liu, Hui Fang, Zi-Hao Yu, Ye-Xiong Li

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Receiver operating characteristic analysis of prediction for gastric cancer development using serum pepsinogen and Helicobacter pylori antibody tests

Chisato Hamashima, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane, for the JPHC Study Group

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target

Cai M. Roberts, Sophia A. Shahin, Joana Loeza, Thanh H. Dellinger, John C. Williams, Carlotta A. Glackin

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Radiofrequency ablation for liver metastases in patients with gastric cancer as an alternative to hepatic resection

Jin Won Lee, Moon Hyung Choi, Young Joon Lee, Bandar Ali, Han Mo Yoo, Kyo Young Song, Cho Hyun Park

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A survey to determine usual care after cancer treatment within the United Kingdom national health service

M. Duncan, J. Deane, P. D. White, D. Ridge, R. Roylance, A. Korszun, T. Chalder, K. S. Bhui, M. A. Thaha, L. Bourke, on behalf of the SURECAN investigators

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial

F. M. Sullivan, Eoghan Farmer, Frances S. Mair, Shaun Treweek, Denise Kendrick, Cathy Jackson, Chris Robertson, Andrew Briggs, Colin McCowan, Laura Bedford, Ben Young, Kavita Vedhara, Stephanie Gallant, Roberta Littleford, John Robertson, Herb Sewell, Alistair Dorward, Joseph Sarvesvaran, Stuart Schembri

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A multi-center phase II study and biomarker analysis of combined cetuximab and modified FOLFIRI as second-line treatment in patients with metastatic gastric cancer

Xin Liu, Weijian Guo, Wen Zhang, Jiliang Yin, Jun Zhang, Xiaodong Zhu, Tianshu Liu, Zhiyu Chen, Biyun Wang, Jianhua Chang, Fangfang Lv, Xiaonan Hong, Huijie Wang, Jialei Wang, Xinmin Zhao, Xianghua Wu, Jin Li

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Endothelial Dll4 overexpression reduces vascular response and inhibits tumor growth and metastasization in vivo

Alexandre Trindade, Dusan Djokovic, Joana Gigante, Liliana Mendonça, António Duarte

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway

Michele Joana Alves, Raquel Galvão Figuerêdo, Flavia Figueiredo Azevedo, Diego Alexandre Cavallaro, Nelson Inácio Pinto Neto, Joanna Darck Carola Lima, Emidio Matos-Neto, Katrin Radloff, Daniela Mendes Riccardi, Rodolfo Gonzalez Camargo, Paulo Sérgio Martins De Alcântara, José Pinhata Otoch, Miguel Luiz Batista Junior, Marília Seelaender

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Establishment of patient-derived gastric cancer xenografts: a useful tool for preclinical evaluation of targeted therapies involving alterations in HER-2, MET and FGFR2 signaling pathways

Haiyong Wang, Jun Lu, Jian Tang, Shitu Chen, Kuifeng He, Xiaoxia Jiang, Weiqin Jiang, Lisong Teng

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Functional analysis of fatty acid binding protein 7 and its effect on fatty acid of renal cell carcinoma cell lines

Naohisa Takaoka, Tatsuya Takayama, Seiichiro Ozono

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

iCanADAPT Early protocol: randomised controlled trial (RCT) of clinician supervised transdiagnostic internet-delivered cognitive behaviour therapy (iCBT) for depression and/or anxiety in early stage cancer survivors -vs- treatment as usual

M. J. Murphy, J. M. Newby, P. Butow, L. Kirsten, K. Allison, S. Loughnan, M. A. Price, J. Shaw, H. Shepherd, J. Smith, G. Andrews

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells

Ancély F. dos Santos, Letícia F. Terra, Rosangela A. M. Wailemann, Talita C. Oliveira, Vinícius de Morais Gomes, Marcela Franco Mineiro, Flávia Carla Meotti, Alexandre Bruni-Cardoso, Maurício S. Baptista, Leticia Labriola

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Spectrum and frequencies of BRCA1/2 mutations in Bulgarian high risk breast cancer patients

Rumyana Ivanova Dodova, Atanaska Velichkova Mitkova, Daniela Rosenova Dacheva, Lina Basam Hadjo, Alexandrina Ivanova Vlahova, Margarita Stoyanova Taushanova – Hadjieva, Spartak Stoyanov Valev, Marija Mitko Caulevska, Stanislava Dimitrova Popova, Ivan Emilov Popov, Tihomir Iliichev Dikov, Theophil Angelov Sedloev, Atanas Stefanov Ionkov, Konstanta Velinova Timcheva, Svetlana Liubomirova Christova, Ivo Marinov Kremensky, Vanio Ivanov Mitev, Radka Petrova Kaneva

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: The Women’s wellness after cancer program: a multisite, single-blinded, randomised controlled trial protocol

Debra Anderson, Charrlotte Seib, Dian Tjondronegoro, Jane Turner, Leanne Monterosso, Amanda McGuire, Janine Porter-Steele, Wei Song, Patsy Yates, Neil King, Leonie Young, Kate White, Kathryn Lee, Sonj Hall, Mei Krishnasamy, Kathy Wells, Sarah Balaam, Alexandra L. McCarthy

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Objective response to mTOR inhibition in a metastatic collision tumor of the liver composed of melanoma and adenocarcinoma with TSC1 loss: a case report

Munveer S. Bhangoo, Jenny Y. Zhou, Siraj M. Ali, Russell Madison, Alexa B. Schrock, Carrie Costantini

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Characterizing and prognosticating chronic lymphocytic leukemia in the elderly: prospective evaluation on 455 patients treated in the United States

Chadi Nabhan, Anthony Mato, Christopher R. Flowers, David L. Grinblatt, Nicole Lamanna, Mark A. Weiss, Matthew S. Davids, Arlene S. Swern, Shriya Bhushan, Kristen Sullivan, E. Dawn Flick, Pavel Kiselev, Jeff P. Sharman

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells

Yao Huang, David J. Burns, Benjamin E. Rich, Ian A. MacNeil, Abhijit Dandapat, Sajjad M. Soltani, Samantha Myhre, Brian F. Sullivan, Carol A. Lange, Leo T. Furcht, Lance G. Laing

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Aprepitant for refractory cutaneous T-cell lymphoma-associated pruritus: 4 cases and a review of the literature

Johanna S. Song, Marianne Tawa, Nicole G. Chau, Thomas S. Kupper, Nicole R. LeBoeuf

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro

Jia Pei Lim, Sukanya Shyamasundar, Jayantha Gunaratne, Olivia Jane Scully, Ken Matsumoto, Boon Huat Bay

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model

Jo-Anne de la Mare, Tamarin Jurgens, Adrienne L. Edkins

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells

Mercè Padró, Raymond J. Louie, Brian V. Lananna, Adam J. Krieg, Luika A. Timmerman, Denise A. Chan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures

Ravi S. Narayan, Carlos A. Fedrigo, Eelke Brands, Rogier Dik, Lukas J.A. Stalpers, Brigitta G. Baumert, Ben J. Slotman, Bart A. Westerman, Godefridus J. Peters, Peter Sminia

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms

Marina Badenes, Alexandre Trindade, Hugo Pissarra, Luís Lopes-da-Costa, António Duarte

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Morphological and phenotypical features of ovarian metastases in breast cancer patients

Inge T. A. Peters, Merle A. van der Steen, Bertine W. Huisman, Carina G. J .M. Hilders, Vincent T. H. B. M. Smit, Alexander L. Vahrmeijer, Cornelis F. M. Sier, J. Baptist Trimbos, Peter J. K. Kuppen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Simultaneous analysis of miRNA-mRNA in human meningiomas by integrating transcriptome: A relationship between PTX3 and miR-29c

Altay Burak Dalan, Sukru Gulluoglu, Emre Can Tuysuz, Aysegul Kuskucu, Cumhur Kaan Yaltirik, Oguz Ozturk, Ugur Ture, Omer Faruk Bayrak

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Uniform FDG-PET guided GRAdient Dose prEscription to reduce late Radiation Toxicity (UPGRADE-RT): study protocol for a randomized clinical trial with dose reduction to the elective neck in head and neck squamous cell carcinoma

Sven van den Bosch, Tim Dijkema, Martina C. Kunze-Busch, Chris H. J. Terhaard, Cornelis P. J. Raaijmakers, Patricia A. H. Doornaert, Frank J. P. Hoebers, Marije R. Vergeer, Bas Kreike, Oda B. Wijers, Wim J. G. Oyen, Johannes H. A. M. Kaanders

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Investigating young women’s motivations to engage in early mammography screening in Switzerland: results of a cross-sectional study

Nanon H. M. Labrie, Ramona Ludolph, Peter J. Schulz

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Tumor burden monitoring using cell-free tumor DNA could be limited by tumor heterogeneity in advanced breast cancer and should be evaluated together with radiographic imaging

José Angel García-Saenz, Patricia Ayllón, Marion Laig, Daniel Acosta-Eyzaguirre, Marta García-Esquinas, Myriam Montes, Julián Sanz, Miguel Barquín, Fernando Moreno, Vanesa Garcia-Barberan, Eduardo Díaz-Rubio, Trinidad Caldes, Atocha Romero

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prospective phase II trial of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy

Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Won Ki Kang, Ho Yeong Lim

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Midkine is a potential novel marker for malignant mesothelioma with different prognostic and diagnostic values from mesothelin

Guntulu Ak, Yuji Tada, Hideaki Shimada, Selma Metintas, Masaaki Ito, Kenzo Hiroshima, Masatoshi Tagawa, Muzaffer Metintas

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A systematic review of prognostic factors at the end of life for people with a hematological malignancy

Elise Button, Raymond Javan Chan, Shirley Chambers, Jason Butler, Patsy Yates

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Characteristics of early-onset hematotoxicity of sunitinib in Japanese patients with renal cell carcinoma

Renpei Kato, Yoichiro Kato, Tomohiko Matsuura, Mitsugu Kanehira, Ryo Takata, Wataru Obara

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

u-PAR expression in cancer associated fibroblast: new acquisitions in multiple myeloma progression

S Ciavarella, A Laurenzana, S De Summa, B Pilato, A Chillà, R Lacalamita, C Minoia, F Margheri, A Iacobazzi, A Rana, F Merchionne, G Fibbi, M Del Rosso, A Guarini, S Tommasi, S Serratì

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Innovative substance 2250 as a highly promising anti-neoplastic agent in malignant pancreatic carcinoma - in vitro and in vivo

M. Buchholz, B. Majchrzak-Stiller, S. Hahn, D. Vangala, R. W. Pfirrmann, W. Uhl, C. Braumann, A. M. Chromik

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Stage IVb thymic carcinoma: patients with lymph node metastases have better prognoses than those with hematogenous metastases

Yu Yang, Xing-Wen Fan, Hong-Bing Wang, Yin Xu, Dou-Dou Li, Kai-Liang Wu

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Design of a randomized controlled trial of physical training and cancer (Phys-Can) – the impact of exercise intensity on cancer related fatigue, quality of life and disease outcome

Sveinung Berntsen, Neil K Aaronson, Laurien Buffart, Sussanne Börjeson, Ingrid Demmelmaier, Maria Hellbom, Pernille Hojman, Helena Igelström, Birgitta Johansson, Ronnie Pingel, Truls Raastad, Galina Velikova, Pernilla Åsenlöf, Karin Nordin

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

DNA alterations in Cd133+ and Cd133- tumour cells enriched from intra-operative human colon tumour biopsies

Diana Cervantes-Madrid, Yvonne Wettergren, Peter Falk, Kent Lundholm, Annika G. Asting

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A possible association of baseline serum IL-17A concentrations with progression-free survival of metastatic colorectal cancer patients treated with a bevacizumab-based regimen

Emilie Lereclus, Mira Tout, Alban Girault, Nadine Baroukh, Morgane Caulet, Christophe Borg, Olivier Bouché, David Ternant, Gilles Paintaud, Thierry Lecomte, William Raoul

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Malignant acrospiroma: a case report in the era of next generation sequencing

Maria Diab, Ali Gabali, Muaiad Kittaneh

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

ABCG2 is a potential prognostic marker of overall survival in patients with clear cell renal cell carcinoma

Haofei Wang, Fangxiu Luo, Zhe Zhu, Zhaoping Xu, Xin Huang, Renyi Ma, Hongchao He, Yu Zhu, Kun Shao, Juping Zhao

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Case management to increase quality of life after cancer treatment: a randomized controlled trial

Nathalie Scherz, Irène Bachmann-Mettler, Corinne Chmiel, Oliver Senn, Nathalie Boss, Katarina Bardheci, Thomas Rosemann

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion

Bethan A. Frugtniet, Tracey A. Martin, Lijian Zhang, Wen G. Jiang

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

Varun V. Varadarajan, Elizabeth K. Pace, Vatsal Patel, Raja Sawhney, Robert J. Amdur, Peter T. Dziegielewski

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Can we use gonadotropin plasma concentration as surrogate marker for BMI-related incomplete estrogen suppression in breast cancer patients receiving anastrozole?

A. Oberguggenberger, V. Meraner, M. Sztankay, B. Beer, G. Weigel, H. Oberacher, G. Kemmler, T. Czech, B. Holzner, L. Wildt, B. Sperner-Unterweger, M. Daniaux, M. Hubalek

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy

Xinxing Li, Hao Lu, Kai Xu, Haolu Wang, Xiaowen Liang, Zhiqian Hu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer

Tyler McInnes, Donghui Zou, Dasari S. Rao, Francesca M. Munro, Vicky L. Phillips, John L. McCall, Michael A. Black, Anthony E. Reeve, Parry J. Guilford

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Protocol of the PANCALYZE trial: a multicenter, prospective study investigating the tumor biomarkers CXCR4, SMAD4, SOX9 and IFIT3 in patients with resected pancreatic adenocarcinoma to predict the pattern of recurrence of the disease

Felix C. Popp, Marie Christine Popp, Yue Zhao, Christopher Betzler, Siegfried Kropf, Benjamin Garlipp, Christoph Benckert, Thomas Kalinski, Hans Lippert, Christiane J. Bruns

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Amplification and up-regulation of MIR30D was associated with disease progression of cervical squamous cell carcinomas

You Zhou, Yinghua Hao, Yuxia Li, Ruizhen Li, Ruifang Wu, Shubin Wang, Zhengyu Fang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Distribution of Ki-67 values within HER2 & ER/PgR expression variants of ductal breast cancers as a potential link between IHC features and breast cancer biology

Sven Kurbel, Branko Dmitrović, Ksenija Marjanović, Damir Vrbanec, Antonije Juretić

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Anti-tumor effects of everolimus and metformin are complementary and glucose-dependent in breast cancer cells

Gerke Ariaans, Mathilde Jalving, Emma Geertruida Elisabeth de Vries, Steven de Jong

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

Marcus W. Stepp, Mark A. Doll, David J. Samuelson, Mary Ann G. Sanders, J. Christopher States, David W. Hein

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device

Akira Yamauchi, Masahiro Yamamura, Naoki Katase, Masumi Itadani, Naoko Okada, Kayoko Kobiki, Masafumi Nakamura, Yoshiyuki Yamaguchi, Futoshi Kuribayashi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

C. P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J. Mason, Julian E. Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa, Kanchugarakoppal S. Rangappa

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Aberrant expression of ALK and EZH2 in Merkel cell carcinoma

Tuukka Veija, Virve Koljonen, Tom Bohling, Mia Kero, Sakari Knuutila, Virinder Kaur Sarhadi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Clinical impact of postoperative loss in psoas major muscle and nutrition index after radical cystectomy for patients with urothelial carcinoma of the bladder

Makito Miyake, Yosuke Morizawa, Shunta Hori, Nagaaki Marugami, Keiji Shimada, Daisuke Gotoh, Yoshihiro Tatsumi, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka, Kiyohide Fujimoto

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The IGCA staging system is more accurate than AJCC7 system in stratifying survival of patients with gastric cancer in stage III

Ping Shu, Jing Qin, Kuntang Shen, Weidong Chen, Fenglin Liu, Yong Fang, Xuefei Wang, Hongshan Wang, Zhenbin Shen, Yihong Sun, Xinyu Qin

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The germline variants in DNA repair genes in pediatric medulloblastoma: a challenge for current therapeutic strategies

Joanna Trubicka, Tomasz Żemojtel, Jochen Hecht, Katarzyna Falana, Dorota Piekutowska- Abramczuk, Rafał Płoski, Marta Perek-Polnik, Monika Drogosiewicz, Wiesława Grajkowska, Elżbieta Ciara, Elżbieta Moszczyńska, Bożenna Dembowska-Bagińska, Danuta Perek, Krystyna H. Chrzanowska, Małgorzata Krajewska-Walasek, Maria Łastowska

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic value of transforming growth factor-beta in patients with colorectal cancer who undergo surgery: a meta-analysis

Xin-lin Chen, Zhuo-qun Chen, Shui-lian Zhu, Tian-wen Liu, Yi Wen, Yi-sheng Su, Xu-jie Xi, Yue Hu, Lei Lian, Feng-bin Liu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue

Bojana Jovanović, Quanhu Sheng, Robert S. Seitz, Kasey D. Lawrence, Stephan W. Morris, Lance R. Thomas, David R. Hout, Brock L. Schweitzer, Yan Guo, Jennifer A. Pietenpol, Brian D. Lehmann

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Timing of chemotherapy-induced neutropenia predicts prognosis in metastatic colon cancer patients: a retrospective study in mFOLFOX6 -treated patients

Yang Chen, YanRong Wang, Yan Shi, GuangHai Dai

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The efficacy and safety of CapeOX plus bevacizumab therapy followed by capecitabine plus bevacizumab maintenance therapy in patients with metastatic colorectal cancer: a multi-center, single-arm, phase II study (CCOG-0902)

Goro Nakayama, Kiyoshi Ishigure, Hiroyuki Yokoyama, Keisuke Uehara, Hiroshi Kojima, Akiharu Ishiyama, Naomi Hayashi, Nao Takano, Norifumi Hattori, Daisuke Kobayashi, Chie Tanaka, Masamichi Hayashi, Mitsuro Kanda, Suguru Yamada, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Tsutomu Fujii, Kenta Murotani, Yuichi Ando, Yasuhiro Kodera

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Metastatic polyp of the gallbladder from renal cell carcinoma

Bor-Uei Shyr, Shih-Chin Chen, Yi-Ming Shyr, Rheun-Chuan Lee, Shin-E Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Central nervous system progression in advanced non–small cell lung cancer patients with EGFR mutations in response to first-line treatment with two EGFR-TKIs, gefitinib and erlotinib: a comparative study

Meng-Xia Li, Hao He, Zhi-Hua Ruan, Yu-Xi Zhu, Rong-Qing Li, Xiao He, Bao-Hua Lan, Zhi-Min Zhang, Guo-Dong Liu, Hua-Liang Xiao, Yan Wu, Bo Zhu, Ge Wang, Zhen-Zhou Yang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Glucose and lipoprotein biomarkers and breast cancer severity using data from the Swedish AMORIS cohort

Jennifer C Melvin, Hans Garmo, Lars Holmberg, Niklas Hammar, Göran Walldius, Ingmar Jungner, Mats Lambe, Mieke Van Hemelrijck

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A prospective comparison of UroVysion FISH and urine cytology in bladder cancer detection

Hugh J. Lavery, Boriana Zaharieva, Andrew McFaddin, Nyla Heerema, Kamal S. Pohar

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Long non-coding RNA XIST regulates PTEN expression by sponging miR-181a and promotes hepatocellular carcinoma progression

Shuzhen Chang, Binhe Chen, Xiaoyan Wang, Keqin Wu, Yuqiu Sun

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer

Tristan Lerbs, Savita Bisht, Sebastian Schölch, Mathieu Pecqueux, Glen Kristiansen, Martin Schneider, Bianca T. Hofmann, Thilo Welsch, Christoph Reissfelder, Nuh N. Rahbari, Johannes Fritzmann, Peter Brossart, Jürgen Weitz, Georg Feldmann, Christoph Kahlert

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Myoepithelial carcinoma with RB1 mutation: remarkable chemosensitivity to carcinoma of unknown origin therapy

Timothy M. Hoggard, Evita Henderson-Jackson, Marilyn M. Bui, Jamie Caracciolo, Jamie K. Teer, Sean Yoder, Odion Binitie, Ricardo J. Gonzalez, Andrew S. Brohl, Damon R. Reed

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Sidedness is prognostic in locoregional colon cancer: an analysis of 9509 Australian patients

Daniel Brungs, Morteza Aghmesheh, Paul de Souza, Weng Ng, Wei Chua, Martin Carolan, Philip Clingan, Emma Healey, June Rose, Tameika Tubaro, Marie Ranson

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Emerging role of mutations in epigenetic regulators including MLL2 derived from The Cancer Genome Atlas for cervical cancer

Xia Li

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

A multicentre randomised controlled trial to evaluate the efficacy, morbidity and functional outcome of endoscopic transanal proctectomy versus laparoscopic proctectomy for low-lying rectal cancer (ETAP-GRECCAR 11 TRIAL): rationale and design

Bernard Lelong, Cécile de Chaisemartin, Helene Meillat, Sandra Cournier, Jean Marie Boher, Dominique Genre, Mehdi Karoui, Jean Jacques Tuech, Jean Robert Delpero, the French Research Group of Rectal Cancer Surgery (GRECCAR)

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Optimal treatment and prognostic factors for esthesioneuroblastoma: retrospective analysis of 187 Chinese patients

Le Xiong, Xiao-Li Zeng, Chang-Kuo Guo, An-Wen Liu, Long Huang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Tiamulin inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of CD73

Xu Yang, Shimin Pei, Huanan Wang, Yipeng Jin, Fang Yu, Bin Zhou, Hong Zhang, Di Zhang, Degui Lin

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cost-effectiveness of response evaluation after chemoradiation in patients with advanced oropharyngeal cancer using 18F–FDG-PET-CT and/or diffusion-weighted MRI

Marjolein JE Greuter, Charlotte S Schouten, Jonas A Castelijns, Pim de Graaf, Emile FI Comans, Otto S Hoekstra, Remco de Bree, Veerle MH Coupé

01.12.2017 | Debate | Ausgabe 1/2017 Open Access

Infections and cancer: the “fifty shades of immunity” hypothesis

Camille Jacqueline, Aurélie Tasiemski, Gabriele Sorci, Beata Ujvari, Fatima Maachi, Dorothée Missé, François Renaud, Paul Ewald, Frédéric Thomas, Benjamin Roche

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Gamma probe and ultrasound guided fine needle aspiration cytology of the sentinel node (GULF) trial - overview of the literature, pilot and study protocol

Charlotte M.C. Oude Ophuis, Lisa B. Koppert, Cécile de Monyé, Carolien H.M. van Deurzen, Senada Koljenović, Alexander C.J. van Akkooi, Cornelis Verhoef, Dirk J. Grünhagen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Weight change during chemotherapy in breast cancer patients: a meta-analysis

M.M.G.A. van den Berg, R.M. Winkels, J.Th.C.M. de Kruif, H.W.M van Laarhoven, M. Visser, J.H.M. de Vries, Y.C. de Vries, E. Kampman

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Hypermethylation of CDKN2A exon 2 in tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients

Melanie Spitzwieser, Elisabeth Entfellner, Bettina Werner, Walter Pulverer, Georg Pfeiler, Stefan Hacker, Margit Cichna-Markl

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression

Marjolaine Ngollo, Andre Lebert, Marine Daures, Gaelle Judes, Khaldoun Rifai, Lucas Dubois, Jean-Louis Kemeny, Frederique Penault-Llorca, Yves-Jean Bignon, Laurent Guy, Dominique Bernard-Gallon

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Systemic therapy in younger and elderly patients with advanced biliary cancer: sub-analysis of ABC-02 and twelve other prospective trials

Mairéad Geraldine McNamara, John Bridgewater, Andre Lopes, Harpreet Wasan, David Malka, Lars Henrik Jensen, Takuji Okusaka, Jennifer J. Knox, Dorothea Wagner, David Cunningham, Jenny Shannon, David Goldstein, Markus Moehler, Tanios Bekaii-Saab, Juan W. Valle

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study

Yasushi Horimasu, Nobuhisa Ishikawa, Sonosuke Tanaka, Chihiro Hirano, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori, Nobuoki Kohno

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Effect of individualized communication skills training on physicians’ discussion of clinical trials in oncology: results from a randomized controlled trial

Alexander Wuensch, Tanja Goelz, Gabriele Ihorst, Darcey D. Terris, Hartmut Bertz, Juergen Bengel, Michael Wirsching, Kurt Fritzsche

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Adjuvant treatment recommendations for patients with ER-positive/HER2-negative early breast cancer by Swiss tumor boards using the 21-gene recurrence score (SAKK 26/10)

Bernhard C. Pestalozzi, Christoph Tausch, Konstantin J. Dedes, Christoph Rochlitz, Stefan Zimmermann, Roger von Moos, Ralph Winterhalder, Thomas Ruhstaller, Andreas Mueller, Katharina Buser, Markus Borner, Urban Novak, Catrina Uhlmann Nussbaum, Bettina Seifert, Martin Bigler, Vincent Bize, Simona Berardi Vilei, Christoph Rageth, Stefan Aebi, The Swiss Group for Clinical Cancer Research (SAKK)

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Alpha–fetoprotein elevation in NUT midline carcinoma: a case report

Lorenzo D’Ambrosio, Erica Palesandro, Marina Moretti, Giuseppe Pelosi, Alessandra Fabbri, Fabrizio Carnevale Schianca, Massimo Aglietta, Giovanni Grignani

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A prediction model for lymph node metastases using pathologic features in patients intraoperatively diagnosed as stage I non-small cell lung cancer

Fei Zhao, Yue Zhou, Peng-Fei Ge, Chen-Jun Huang, Yue Yu, Jun Li, Yun-Gang Sun, Yang-Chun Meng, Jian-Xia Xu, Ting Jiang, Zhi-Xuan Zhang, Jin-Peng Sun, Wei Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer

Xiangbin Xing, Weibin Cai, Sanmei Ma, Yongfei Wang, Huijuan Shi, Ming Li, Jinxia Jiao, Yang Yang, Longshan Liu, Xiangliang Zhang, Minhu Chen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC)

Ting Zhou, Jianhua Zhan, Wenfeng Fang, Yuanyuan Zhao, Yunpeng Yang, Xue Hou, Zhonghan Zhang, Xiaobo He, Yaxiong Zhang, Yan Huang, Li Zhang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Overview of cancer incidence and mortality among people living with HIV/AIDS in British Columbia, Canada: Implications for HAART use and NADM development

Connie G. Chiu, Danielle Smith, Kate A. Salters, Wendy Zhang, Steve Kanters, David Milan, Julio S.G. Montaner, Andy Coldman, Robert S. Hogg, Sam M. Wiseman

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Effects of omega-3 fatty acids on patients undergoing surgery for gastrointestinal malignancy: a systematic review and meta-analysis

Jing Yu, Lian Liu, Yue Zhang, Jia Wei, Fan Yang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Appraising the holistic value of Lenvatinib for radio-iodine refractory differentiated thyroid cancer: A multi-country study applying pragmatic MCDA

Monika Wagner, Hanane Khoury, Liga Bennetts, Patrizia Berto, Jenifer Ehreth, Xavier Badia, Mireille Goetghebeur

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns

Marie K. Kirby, Ryne C. Ramaker, Brian S. Roberts, Brittany N. Lasseigne, David S. Gunther, Todd C. Burwell, Nicholas S. Davis, Zulfiqar G. Gulzar, Devin M. Absher, Sara J. Cooper, James D. Brooks, Richard M. Myers

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrants

Siwa Chan, Jeon-Hor Chen, Shunshan Li, Rita Chang, Darh-Cherng Yeh, Ruey-Feng Chang, Lee-Ren Yeh, Jessica Kwong, Min-Ying Su

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic value of pretreatment standardized uptake value of F-18-fluorodeoxyglucose PET in patients with gastric cancer: a meta-analysis

Zhonghua Wu, Junhua Zhao, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Bin Ma, Zhenning Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The treatment of primary mediastinal large B-cell lymphoma: a two decades monocentric experience with 98 patients

Alessandro Broccoli, Beatrice Casadei, Vittorio Stefoni, Cinzia Pellegrini, Federica Quirini, Lorenzo Tonialini, Alice Morigi, Miriam Marangon, Lisa Argnani, Pier Luigi Zinzani

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Arsenic treatment increase Aurora-A overexpression through E2F1 activation in bladder cells

Yu-Ting Kao, Chin-Han Wu, Shan-Ying Wu, Sheng-Hui Lan, Hsiao-Sheng Liu, Ya-Shih Tseng

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Transcriptional changes induced by bevacizumab combination therapy in responding and non-responding recurrent glioblastoma patients

Thomas Urup, Line Mærsk Staunstrup, Signe Regner Michaelsen, Kristoffer Vitting-Seerup, Marc Bennedbæk, Anders Toft, Lars Rønn Olsen, Lars Jønson, Shohreh Issazadeh-Navikas, Helle Broholm, Petra Hamerlik, Hans Skovgaard Poulsen, Ulrik Lassen

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Contrast-enhanced US with Perfluorobutane(Sonazoid) used as a surveillance test for Hepatocellular Carcinoma (HCC) in Cirrhosis (SCAN): an exploratory cross-sectional study for a diagnostic trial

Ji Hoon Park, Mi-Suk Park, So Jung Lee, Woo Kyoung Jeong, Jae Young Lee, Min Jung Park, Kyunghwa Han, Chung Mo Nam, Seong Ho Park, Kyoung Ho Lee

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer

Vivian Labovsky, Leandro Marcelo Martinez, Kevin Mauro Davies, María de Luján Calcagno, Hernán García-Rivello, Alejandra Wernicke, Leonardo Feldman, Ayelén Matas, María Belén Giorello, Francisco Raúl Borzone, Hosoon Choi, Scott C. Howard, Norma Alejandra Chasseing

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Efficacy of irreversible EGFR-TKIs for the uncommon secondary resistant EGFR mutations L747S, D761Y, and T854A

Masato Chiba, Yosuke Togashi, Eri Bannno, Yoshihisa Kobayashi, Yu Nakamura, Hidetoshi Hayashi, Masato Terashima, Marco A. De Velasco, Kazuko Sakai, Yoshihiko Fujita, Tetsuya Mitsudomi, Kazuto Nishio

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Imatinib treatment of poor prognosis mesenchymal-type primary colon cancer: a proof-of-concept study in the preoperative window period (ImPACCT)

I. Ubink, H. J. Bloemendal, S. G. Elias, M. A. Brink, M. P. Schwartz, Y. C. W. Holierhoek, P. M. Verheijen, A. W. Boerman, R. H. J. Mathijssen, W. W. J. de Leng, R. A. de Weger, W. M. U. van Grevenstein, M. Koopman, M. P. Lolkema, O. Kranenburg, I. H. M. Borel Rinkes

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prevalence and prognostic implications of psychological distress in patients with gastric cancer

Gun Min Kim, Seung Jun Kim, Su Kyung Song, Hye Ryun Kim, Beo Deul Kang, Sung Hoon Noh, Hyun Cheol Chung, Kyung Ran Kim, Sun Young Rha

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

A protocol for a cluster-randomized controlled trial of a self-help psycho-education programme to reduce diagnosis delay in women with breast cancer symptoms in Indonesia

Hari Setyowibowo, Marit Sijbrandij, Aulia Iskandarsyah, Joke A. M. Hunfeld, Sawitri S. Sadarjoen, Dharmayanti F. Badudu, Drajat R. Suardi, Jan Passchier

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The prognostic value of the preoperative c-reactive protein/albumin ratio in ovarian cancer

Yubo Liu, Shengfu Chen, Chengyu Zheng, Miao Ding, Lan Zhang, Liangan Wang, Meiqing Xie, Jianhua Zhou

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Regular recreational physical activity and risk of head and neck cancer

Chen-Lin Lin, Wei-Ting Lee, Chun-Yen Ou, Jenn-Ren Hsiao, Cheng-Chih Huang, Jehn-Shyun Huang, Tung-Yiu Wong, Ken-Chung Chen, Sen-Tien Tsai, Sheen-Yie Fang, Tze-Ta Huang, Jiunn-Liang Wu, Yuan-Hua Wu, Wei-Ting Hsueh, Chia-Jui Yen, Yu-Hsuan Lai, Hsiao-Chen Liao, Shang-Yin Wu, Ming-Wei Yang, Forn-Chia Lin, Jang-Yang Chang, Yi-Hui Wang, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S. Chang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Is adjuvant chemotherapy necessary in pT1N1 gastric cancer?

Hyun Beak Shin, Ji Yeong An, Seung Hyoung Lee, Yoon Young Choi, Jong Won Kim, Soo Sang Sohn, Sung Hoon Noh

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The safety and efficacy of percutaneous intraductal radiofrequency ablation in unresectable malignant biliary obstruction: A single-institution experience

Wei Cui, Wenzhe Fan, Mingjian Lu, Yingqiang Zhang, Wang Yao, Jiaping Li, Yu Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Observation of Zn-photoprotoporphyrin red Autofluorescence in human bronchial cancer using color-fluorescence endoscopy

Yoshinobu Ohsaki, Takaaki Sasaki, Satoshi Endo, Masahiro Kitada, Shunsuke Okumura, Noriko Hirai, Yoshihiro Kazebayashi, Eri Toyoshima, Yasushi Yamamoto, Kaneyoshi Takeyama, Susumu Nakajima, Isao Sakata

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Effect of genetic variants and traits related to glucose metabolism and their interaction with obesity on breast and colorectal cancer risk among postmenopausal women

Su Yon Jung, Eric M. Sobel, Jeanette C. Papp, Zuo-Feng Zhang

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

A mobile application of breast cancer e-support program versus routine Care in the treatment of Chinese women with breast cancer undergoing chemotherapy: study protocol for a randomized controlled trial

Jiemin Zhu, Lyn Ebert, Xiangyu Liu, Sally Wai-Chi Chan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

MiR-23b controls ALDH1A1 expression in cervical cancer stem cells

Weiwen Wang, Yang Li, Na Liu, Yu Gao, Long Li

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Distinct immunophenotypes and prognostic factors in renal cell carcinoma with sarcomatoid differentiation: a systematic study of 19 immunohistochemical markers in 42 cases

Wenjuan Yu, Yuewei Wang, Yanxia Jiang, Wei Zhang, Yujun Li

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Potential of extravasated platelet aggregation as a surrogate marker for overall survival in patients with advanced gastric cancer treated with preoperative docetaxel, cisplatin and S-1: a retrospective observational study

Hiroto Saito, Sachio Fushida, Tomoharu Miyashita, Katsunobu Oyama, Takahisa Yamaguchi, Tomoya Tsukada, Jun Kinoshita, Hidehiro Tajima, Itasu Ninomiya, Tetsuo Ohta

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognosis and treatment of non-metastatic primary and secondary breast angiosarcoma: a comparative study

Ming Yin, Wenge Wang, Joseph J. Drabick, Harvey A. Harold

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Influence of presence/absence of thyroid gland on the cutoff value for thyroglobulin in lymph-node aspiration to detect metastatic papillary thyroid carcinoma

Huan Zhao, Yong Wang, Min-jie Wang, Zhi-hui Zhang, Hai-rui Wang, Bing Zhang, Hui-qin Guo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Long-term results of early adjuvant concurrent chemoradiotherapy for high-risk, early stage uterine cervical cancer patients after radical hysterectomy

Sang-Won Kim, Mison Chun, Hee-Sug Ryu, Suk-Joon Chang, Tae Wook Kong, Young-Taek Oh, Seung Hee Kang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A randomized controlled trial of physical activity, dietary habit, and distress management with the Leadership and Coaching for Health (LEACH) program for disease-free cancer survivors

Young Ho Yun, Young Ae Kim, Myung Kyung Lee, Jin Ah Sim, Byung-Ho Nam, Sohee Kim, Eun Sook Lee, Dong-Young Noh, Jae-Young Lim, Sung Kim, Si-Young Kim, Chi-Heum Cho, Kyung Hae Jung, Mison Chun, Soon Nam Lee, Kyong Hwa Park, Sohee Park

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Streamlining staging of lung and colorectal cancer with whole body MRI; study protocols for two multicentre, non-randomised, single-arm, prospective diagnostic accuracy studies (Streamline C and Streamline L)

Stuart A. Taylor, Sue Mallett, Anne Miles, Sandy Beare, Gauraang Bhatnagar, John Bridgewater, Rob Glynne-Jones, Vicky Goh, Ashley M. Groves, Sam M. Janes, Dow Mu Koh, Steve Morris, Alison Morton, Neal Navani, Alf Oliver, Anwar R. Padhani, Shonit Punwani, Andrea G. Rockall, Steve Halligan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Diagnostic value of endoscopic appearance during ductoscopy in patients with pathological nipple discharge

Ye Han, Jianyi Li, Sijia Han, Shi Jia, Yang Zhang, Wenhai Zhang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells

Jiyoun Yeo, Erin L. Crawford, Xiaolu Zhang, Sadik Khuder, Tian Chen, Albert Levin, Thomas M. Blomquist, James C. Willey

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Surfactant protein-D predicts prognosis of interstitial lung disease induced by anticancer agents in advanced lung cancer: a case control study

Kota Nakamura, Motoyasu Kato, Takehito Shukuya, Keita Mori, Yasuhito Sekimoto, Hiroaki Ihara, Ryota Kanemaru, Ryo Ko, Rina Shibayama, Ken Tajima, Ryo Koyama, Naoko Shimada, Osamu Nagashima, Fumiyuki Takahashi, Shinichi Sasaki, Kazuhisa Takahashi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Immunohistochemical evaluation of epithelial ovarian carcinomas identifies three different expression patterns of the MX35 antigen, NaPi2b

Kristina Levan, Matin Mehryar, Constantina Mateoiu, Per Albertsson, Tom Bäck, Karin Sundfeldt

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Hepatitis B virus infection and active replication promote the formation of vascular invasion in hepatocellular carcinoma

Xubiao Wei, Nan Li, Shanshan Li, Jie Shi, Weixing Guo, Yaxin Zheng, Shuqun Cheng

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

MicroRNA-30a regulates cell proliferation and tumor growth of colorectal cancer by targeting CD73

Minghao Xie, Huabo Qin, Qianxin Luo, Qunsheng Huang, Xiaosheng He, Zihuan Yang, Ping Lan, Lei Lian

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The E2F4 prognostic signature predicts pathological response to neoadjuvant chemotherapy in breast cancer patients

Kenneth M. K. Mark, Frederick S. Varn, Matthew H. Ung, Feng Qian, Chao Cheng

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The repressive effect of miR-148a on Wnt/β-catenin signaling involved in Glabridin-induced anti-angiogenesis in human breast cancer cells

Juan Mu, Dongmei Zhu, Zhaoxia Shen, Shilong Ning, Yun Liu, Juan Chen, Yuan Li, Zhong Li

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Adjuvant radiotherapy after radical cystectomy for patients with muscle invasive bladder cancer: a phase II trial

Valérie Fonteyne, Piet Dirix, Sara Junius, Elke Rammant, Piet Ost, Gert De Meerleer, Martijn Swimberghe, Karel Decaestecker

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways

Kengo Shimazu, Yuji Tada, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Hideaki Shimada, Kenzo Hiroshima, Takao Namiki, Koichiro Tatsumi, Masatoshi Tagawa

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas

Birgitta Lehtinen, Annina Raita, Juha Kesseli, Matti Annala, Kristiina Nordfors, Olli Yli-Harja, Wei Zhang, Tapio Visakorpi, Matti Nykter, Hannu Haapasalo, Kirsi J. Granberg

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

KRAS mutation analysis of single circulating tumor cells from patients with metastatic colorectal cancer

Yuurin Kondo, Kazuhiko Hayashi, Kazuyuki Kawakami, Yukari Miwa, Hiroshi Hayashi, Masakazu Yamamoto

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Ethnic differences in colon cancer care in the Netherlands: a nationwide registry-based study

M. Lamkaddem, M. A. G. Elferink, M. C. Seeleman, E. Dekker, C. J. A. Punt, O. Visser, M. L. Essink-Bot

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Evaluation for inherited and acquired prothrombotic defects predisposing to symptomatic thromboembolism in children with acute lymphoblastic leukemia: a protocol for a prospective, observational, cohort study

Uma H. Athale, Caroline Laverdiere, Trishana Nayiager, Yves-Line Delva, Gary Foster, Lehana Thabane, Anthony KC Chan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Efficacy and safety of rebamipide liquid for chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II study

T. Yokota, T. Ogawa, S. Takahashi, K. Okami, T. Fujii, K. Tanaka, S. Iwae, I. Ota, T. Ueda, N. Monden, K. Matsuura, H. Kojima, S. Ueda, K. Sasaki, Y. Fujimoto, Y. Hasegawa, T. Beppu, H. Nishimori, S. Hirano, Y. Naka, Y. Matsushima, M. Fujii, M. Tahara

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Interval breast cancer characteristics before, during and after the transition from screen-film to full-field digital screening mammography

Rob M. G. van Bommel, Roy Weber, Adri C. Voogd, Joost Nederend, Marieke W. J. Louwman, Dick Venderink, Luc J. A. Strobbe, Matthieu J. C. Rutten, Menno L. Plaisier, Paul N. Lohle, Marianne J. H. Hooijen, Vivianne C.G. Tjan-Heijnen, Lucien E. M. Duijm

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer

Kyojiro Kawakami, Yasunori Fujita, Yoko Matsuda, Tomio Arai, Kengo Horie, Koji Kameyama, Taku Kato, Koichi Masunaga, Yutaka Kasuya, Masashi Tanaka, Kosuke Mizutani, Takashi Deguchi, Masafumi Ito

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Diaphragmatic Surgery and Related Complications In Primary Cytoreduction for Advanced Ovarian, Tubal, and Peritoneal Carcinoma

Shuang Ye, Tiancong He, Shanhui Liang, Xiaojun Chen, Xiaohua Wu, Huijuan Yang, Libing Xiang

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Electronic patient self-Reporting of Adverse-events: Patient Information and aDvice (eRAPID): a randomised controlled trial in systemic cancer treatment

Kate Absolom, Patricia Holch, Lorraine Warrington, Faye Samy, Claire Hulme, Jenny Hewison, Carolyn Morris, Leon Bamforth, Mark Conner, Julia Brown, Galina Velikova, on behalf of the eRAPID systemic treatment work group

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Effect of estrogen receptor β agonists on proliferation and gene expression of ovarian cancer cells

Susanne Schüler-Toprak, Christoph Moehle, Maciej Skrzypczak, Olaf Ortmann, Oliver Treeck

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study

Silvia Delgado-García, Juan-Carlos Martínez-Escoriza, Alfonso Alba, Tina-Aurora Martín-Bayón, Hortensia Ballester-Galiana, Gloria Peiró, Pablo Caballero, Jose Ponce-Lorenzo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Impact of lymphovascular invasion on lymph node metastasis for patients undergoing radical prostatectomy with negative resection margin

Yong Jin Kang, Hyun-Soo Kim, Won Sik Jang, Jong Kyou Kwon, Cheol Yong Yoon, Joo Yong Lee, Kang Su Cho, Won Sik Ham, Young Deuk Choi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Transhepatic arterial infusion chemotherapy using a combination of miriplatin and CDDP powder versus miriplatin alone in the treatment of hepatocellular carcinoma: a randomized controlled trial

Kenya Kamimura, Takeshi Suda, Takeshi Yokoo, Hiroteru Kamimura, Tsutomu Kanefuji, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Nobuo Waguri, Satoshi Yamagiwa, Shuji Terai

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Metastatic non-muscle invasive bladder cancer with meningeal carcinomatosis: case report of an unexpected response

Diego Teyssonneau, Amaury Daste, Vincent Dousset, Jean-Luc Hoepffner, Alain Ravaud, Marine Gross-Goupil

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

MDA-MET-conditioned-medium augments the chemoattractant-dependent migration of MDA-MET cells towards hFOB-conditioned medium and increases collagenase activity

Karis Chin-Quee, Henry J. Donahue

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Clinical benefit of adding oxaliplatin to standard neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a meta-analysis

Oxaliplatin in neoadjuvant treatment for rectal cancer
Francesca De Felice, Ilaria Benevento, Anna Lisa Magnante, Daniela Musio, Nadia Bulzonetti, Rossella Caiazzo, Vincenzo Tombolini

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

A French national breast and thyroid cancer screening programme for survivors of childhood, adolescent and young adult (CAYA) cancers - DeNaCaPST programme

Charlotte Demoor-Goldschmidt, Delphine Drui, Isabelle Doutriaux, Gérard Michel, Pascal Auquier, Agnès Dumas, Claire Berger, Valérie Bernier, Sandrine Bohrer, Pierre-Yves Bondiau, Bruno Filhon, Brice Fresneau, Claire Freycon, Dinu Stefan, Sylvie Helfre, Angela Jackson, Christine Kerr, Anne Laprie, Julie Leseur, Marc-André Mahé, Caroline Oudot, Claire Pluchard, Stéphanie Proust, Hélène Sudour-Bonnange, Céline Vigneron, Nathalie Lassau, Martin Schlumberger, Cécile Faure Conter, Florent de Vathaire

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockade

Thilo Gambichler, Stefanie Strutzmann, Andrea Tannapfel, Laura Susok

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation

Christine Lonjou, Francesca Damiola, Monika Moissonnier, Geoffroy Durand, Irina Malakhova, Vladimir Masyakin, Florence Le Calvez-Kelm, Elisabeth Cardis, Graham Byrnes, Ausrele Kesminiene, Fabienne Lesueur

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The role of BRCA1-IRIS in the development and progression of triple negative breast cancers in Egypt: possible link to disease early lesion

Danielle Bogan, Lucio Meile, Ahmed El Bastawisy, Hend F. Yousef, Abdel-Rahman N. Zekri, Abeer A. Bahnassy, Wael M. ElShamy

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Characterization of genetic aberrations in a single case of metastatic thymic adenocarcinoma

Yeonghun Lee, Sehhoon Park, Se-Hoon Lee, Hyunju Lee

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Retrospective study of nonmucinous appendiceal adenocarcinomas: role of systemic chemotherapy and cytoreductive surgery

Marc Uemura, Wei Qiao, Keith Fournier, Jeffrey Morris, Paul Mansfield, Cathy Eng, Richard E Royal, Robert A Wolff, Kanwal Raghav, Gary N Mann, Michael J Overman

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study

Aleksandar Sekulic, Michael R. Migden, Nicole Basset-Seguin, Claus Garbe, Anja Gesierich, Christopher D. Lao, Chris Miller, Laurent Mortier, Dedee F. Murrell, Omid Hamid, Jorge F. Quevedo, Jeannie Hou, Edward McKenna, Natalie Dimier, Sarah Williams, Dirk Schadendorf, Axel Hauschild, for the ERIVANCE BCC Investigators

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

PD-L1 expressing circulating tumour cells in head and neck cancers

Arutha Kulasinghe, Chris Perry, Liz Kenny, Majid E. Warkiani, Colleen Nelson, Chamindie Punyadeera

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma

Shutaro Yamada, Yoshinori Imura, Takaaki Nakai, Sho Nakai, Naohiro Yasuda, Keiko Kaneko, Hidetatsu Outani, Satoshi Takenaka, Kenichiro Hamada, Akira Myoui, Nobuhito Araki, Takafumi Ueda, Kazuyuki Itoh, Hideki Yoshikawa, Norifumi Naka

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

High lymphatic vessel density and presence of lymphovascular invasion both predict poor prognosis in breast cancer

Song Zhang, Dong Zhang, Mingfu Gong, Li Wen, Cuiwei Liao, Liguang Zou

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

TUmor-volume to breast-volume RAtio for improving COSmetic results in breast cancer patients (TURACOS); a randomized controlled trial

M. Lagendijk, E. L. Vos, A. H. J. Koning, M. G. M. Hunink, J. P. Pignol, E. M. L. Corten, C. de Monye, C. H. M. van Deurzen, J. H. van Dam, W. W. Vrijland, C. M. E. Contant, C. Verhoef, W. van Lankeren, L. B. Koppert

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Proportion of cancer in a Middle eastern country attributable to established risk factors

Maya A. Charafeddine, Sara H. Olson, Deborah Mukherji, Sally N. Temraz, Ghassan K. Abou-Alfa, Ali I. Shamseddine

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids

Stephen Riffle, Ram Naresh Pandey, Morgan Albert, Rashmi S. Hegde

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Survival rates and predictors of survival among colorectal cancer patients in a Malaysian tertiary hospital

Bello Arkilla Magaji, Foong Ming Moy, April Camilla Roslani, Chee Wei Law

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cancer incidence among Finnish male cobalt production workers in 1969–2013: a cohort study

Riitta Sauni, Panu Oksa, Jukka Uitti, Asko Linna, Raimo Kerttula, Eero Pukkala

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Validation of the German version of the Mediterranean Diet Adherence Screener (MEDAS) questionnaire

Katrin Hebestreit, Maryam Yahiaoui-Doktor, Christoph Engel, Walter Vetter, Michael Siniatchkin, Nicole Erickson, Martin Halle, Marion Kiechle, Stephan C. Bischoff

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The adaptation of colorectal cancer cells when forming metastases in the liver: expression of associated genes and pathways in a mouse model

Derya Bocuk, Alexander Wolff, Petra Krause, Gabriela Salinas, Annalen Bleckmann, Christina Hackl, Tim Beissbarth, Sarah Koenig

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cancer risks in a population-based study of 70,570 agricultural workers: results from the Canadian census health and Environment cohort (CanCHEC)

Linda Kachuri, M. Anne Harris, Jill S. MacLeod, Michael Tjepkema, Paul A. Peters, Paul A. Demers

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

XLF-mediated NHEJ activity in hepatocellular carcinoma therapy resistance

Sitian Yang, Xiao Qi Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The optimal extent of gastrectomy for middle-third gastric cancer: distal subtotal gastrectomy is superior to total gastrectomy in short-term effect without sacrificing long-term survival

Xin Ji, Yan Yan, Zhao-De Bu, Zi-Yu Li, Ai-Wen Wu, Lian-Hai Zhang, Xiao-Jiang Wu, Xiang-Long Zong, Shuang-Xi Li, Fei Shan, Zi-Yu Jia, Jia-Fu Ji

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

The PREgnancy and FERtility (PREFER) study: an Italian multicenter prospective cohort study on fertility preservation and pregnancy issues in young breast cancer patients

Matteo Lambertini, Paola Anserini, Valeria Fontana, Francesca Poggio, Giuseppina Iacono, Annalisa Abate, Alessia Levaggi, Loredana Miglietta, Claudia Bighin, Sara Giraudi, Alessia D’Alonzo, Eva Blondeaux, Davide Buffi, Francesco Campone, Domenico F. Merlo, Lucia Del Mastro

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Anxiety and depression in working-age cancer survivors: a register-based study

Laura Inhestern, Volker Beierlein, Johanna Christine Bultmann, Birgit Möller, Georg Romer, Uwe Koch, Corinna Bergelt

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Barriers and facilitators to smoking cessation in a cancer context: A qualitative study of patient, family and professional views

Mary Wells, Patricia Aitchison, Fiona Harris, Gozde Ozakinci, Andrew Radley, Linda Bauld, Vikki Entwistle, Alastair Munro, Sally Haw, Bill Culbard, Brian Williams

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Hybrid peripheral nerve sheath tumors: report of five cases and detailed review of literature

Nasir Ud Din, Zubair Ahmad, Jamshid Abdul-Ghafar, Rashida Ahmed

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor – β1 (TGF-β1) and potential effects on migration and invasion

Synnove Norvoll Magnussen, Elin Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane Cavalcanti Jacobsen, Bente Mortensen, Tuula Salo, Inigo Martinez-Zubiaurre, Jan-Olof Winberg, Lars Uhlin-Hansen, Gunbjorg Svineng

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Venous thromboembolism in hospitalized patients receiving chemotherapy for malignancies at Japanese community hospital: prospective observational study

Hiromitsu Kitayama, Tomohiro Kondo, Junko Sugiyama, Kazutomo Kurimoto, Yasuhiro Nishino, Michiaki Hirayama, Yasushi Tsuji

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Notch ligand Delta-like 1 as a novel molecular target in childhood neuroblastoma

P. Bettinsoli, G. Ferrari-Toninelli, S. A. Bonini, C. Prandelli, M. Memo

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Clinical impact of postoperative loss in psoas major muscle and nutrition index after radical cystectomy for patients with urothelial carcinoma of the bladder

Makito Miyake, Yosuke Morizawa, Shunta Hori, Nagaaki Marugami, Keiji Shimada, Daisuke Gotoh, Yoshihiro Tatsumi, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka, Kiyohide Fujimoto

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Power of PgR expression as a prognostic factor for ER-positive/HER2-negative breast cancer patients at intermediate risk classified by the Ki67 labeling index

Sasagu Kurozumi, Hiroshi Matsumoto, Yuji Hayashi, Katsunori Tozuka, Kenichi Inoue, Jun Horiguchi, Izumi Takeyoshi, Tetsunari Oyama, Masafumi Kurosumi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Haemoglobin level increase as an efficacy biomarker during axitinib treatment for metastatic renal cell carcinoma: a retrospective study

Alison C. Johnson, Margarida Matias, Helen Boyle, Bernard Escudier, Alicia Molinier, Brigitte Laguerre, Carole Helissey, Pierre-Emmanuel Brachet, Audrey Emmanuelle Dugué, Loic Mourey, Elodie Coquan, Florence Joly

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis

Virginie Williams, Andrée-Anne Grosset, Natalia Zamorano Cuervo, Yves St-Pierre, Marie-Pierre Sylvestre, Louis Gaboury, Nathalie Grandvaux

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Mechanisms of Tanshinone II a inhibits malignant melanoma development through blocking autophagy signal transduction in A375 cell

Xiaojing Li, Zhifeng Li, Xianping Li, Baoguo Liu, Zhijun Liu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Use of the QIAGEN GeneReader NGS system for detection of KRAS mutations, validated by the QIAGEN Therascreen PCR kit and alternative NGS platform

Agus Darwanto, Anne-Mette Hein, Sascha Strauss, Yi Kong, Andrew Sheridan, Dan Richards, Eric Lader, Monika Ngowe, Timothy Pelletier, Danielle Adams, Austin Ricker, Nishit Patel, Andreas Kühne, Simon Hughes, Dan Shiffman, Dirk Zimmermann, Kai te Kaat, Thomas Rothmann

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Addition of rituximab to CHOP-like chemotherapy in first line treatment of primary mediastinal B-cell lymphoma

K. Lisenko, G. Dingeldein, M. Cremer, M. Kriegsmann, A. D. Ho, M. Rieger, M. Witzens-Harig

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Identification of endonuclease domain-containing 1 as a novel tumor suppressor in prostate cancer

Jianguang Qiu, Shubin Peng, Jie Si-Tu, Cheng Hu, Wentao Huang, Yunhua Mao, Wenhan Qiu, Ke Li, Dejuan Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Oligometastases from prostate cancer: local treatment with stereotactic body radiotherapy (SBRT)

Gregor Habl, Christoph Straube, Kilian Schiller, Marciana Nona Duma, Markus Oechsner, Kerstin A. Kessel, Matthias Eiber, Markus Schwaiger, Hubert Kübler, Jürgen E. Gschwend, Stephanie E. Combs

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Disparities of time trends and birth cohort effects on invasive breast cancer incidence in Shanghai and Hong Kong pre- and post-menopausal women

Feng Wang, Lap Ah Tse, Wing-cheong Chan, Carol Chi-hei Kwok, Siu-lan Leung, Cherry Wu, Oscar Wai-kong Mang, Roger Kai-cheong Ngan, Mengjie Li, Wai-cho Yu, Koon-ho Tsang, Sze-hong Law, Xiaoping Miao, Chunxiao Wu, Ying Zheng, Fan Wu, Xiaohong R. Yang, Ignatius Tak-sun Yu

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

First case of B ALL with KMT2A-MAML2 rearrangement: a case report

Estelle Menu, Nathalie Beaufils, Fabrice Usseglio, Estelle Balducci, Marina Lafage Pochitaloff, Regis Costello, Jean Gabert

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy

Hakmin Lee, Yong June Kim, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Cheol Kwak, Hyeon Hoe Kim, Jong Jin Oh, Sang Chul Lee, Sung Kyu Hong, Sang Eun Lee, Seok-Soo Byun, KOrean Renal Cell Carcinoma (KORCC) Group

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Time to endoscopic intervention in patients with upper gastrointestinal patients can be improved with pathway provision

R Singer, P Campbell, C Fernandes, P Statham, D Hochhauser, J Bridgewater

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

MAL gene overexpression as a marker of high-grade serous ovarian carcinoma stem-like cells that predicts chemoresistance and poor prognosis

Laura Zanotti, Chiara Romani, Laura Tassone, Paola Todeschini, Renata Alessandra Tassi, Elisabetta Bandiera, Giovanna Damia, Francesca Ricci, Laura Ardighieri, Stefano Calza, Sergio Marchini, Luca Beltrame, Germana Tognon, Maurizio D’Incalci, Sergio Pecorelli, Enrico Sartori, Franco Odicino, Antonella Ravaggi, Eliana Bignotti

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Insulin-like growth factor 1 receptor affects the survival of primary prostate cancer patients depending on TMPRSS2-ERG status

Caterina Mancarella, Irene Casanova-Salas, Ana Calatrava, Maria García-Flores, Cecilia Garofalo, Andrea Grilli, José Rubio-Briones, Katia Scotlandi, José Antonio López-Guerrero

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature

Junichi Yoshizawa, Satoshi Ishizone, Meguru Ikeyama, Jun Nakayama

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The unique C- and N-terminal sequences of Metallothionein isoform 3 mediate growth inhibition and Vectorial active transport in MCF-7 cells

Brent Voels, Liping Wang, Donald A. Sens, Scott H. Garrett, Ke Zhang, Seema Somji

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The role of nature in cancer patients' lives: a systematic review and qualitative meta-synthesis

Sarah Blaschke

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Survival and prognostic factors for survival, cancer specific survival and disease free interval in 239 patients with Hurthle cell carcinoma: a single center experience

Branisav Oluic, Ivan Paunovic, Zlatibor Loncar, Vladimir Djukic, Aleksandar Diklic, Milan Jovanovic, Zeljko Garabinovic, Nikola Slijepcevic, Branislav Rovcanin, Dusan Micic, Aleksandar Filipovic, Vladan Zivaljevic

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Increased serum level of soluble interleukin-2 receptor is associated with a worse response of metastatic clear cell renal cell carcinoma to interferon alpha and sequential VEGF-targeting therapy

Akinori Nukui, Akinori Masuda, Hideyuki Abe, Kyoko Arai, Ken-Ichiro Yoshida, Takao Kamai

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

An increase in long non-coding RNA PANDAR is associated with poor prognosis in clear cell renal cell carcinoma

Yi Xu, Yanyue Tong, Jianyong Zhu, Zhangming Lei, Lijun Wan, Xiuwen Zhu, Feng Ye, Liping Xie

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Switch in KRAS mutational status during an unusual course of disease in a patient with advanced pancreatic adenocarcinoma: implications for translational research

Sibylle Baechmann, Steffen Ormanns, Michael Haas, Stephan Kruger, Anna Remold, Dominik Paul Modest, Thomas Kirchner, Andreas Jung, Jens Werner, Volker Heinemann, Stefan Boeck

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic significance of tumor infiltrating immune cells in oral squamous cell carcinoma

Juan Fang, Xiaoxu Li, Da Ma, Xiangqi Liu, Yichen Chen, Yun Wang, Vivian Wai Yan Lui, Juan Xia, Bin Cheng, Zhi Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

JS-K, a nitric oxide pro-drug, regulates growth and apoptosis through the ubiquitin-proteasome pathway in prostate cancer cells

Guobin Tan, Mingning Qiu, Lieqian Chen, Sai Zhang, Longzhi Ke, Jianjun Liu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Phase I/II study of induction chemotherapy using carboplatin plus irinotecan and sequential thoracic radiotherapy (TRT) for elderly patients with limited-disease small-cell lung cancer (LD-SCLC): TORG 0604

Yuki Misumi, Hiroaki Okamoto, Jiichiro Sasaki, Noriyuki Masuda, Mari Ishii, Tsuneo Shimokawa, Yukio Hosomi, Yusuke Okuma, Makoto Nagamata, Takashi Ogura, Terufumi Kato, Masafumi Sata, Sakiko Otani, Akira Takakura, Koichi Minato, Yosuke Miura, Takuma Yokoyama, Saori Takata, Katsuhiko Naoki, Koshiro Watanabe

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration

Sachi Horibata, Katherine E. Rogers, David Sadegh, Lynne J. Anguish, John L. McElwee, Pragya Shah, Paul R. Thompson, Scott A. Coonrod

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Survival and axillary recurrence following sentinel node-positive breast cancer without completion axillary lymph node dissection: the randomized controlled SENOMAC trial

Jana de Boniface, Jan Frisell, Yvette Andersson, Leif Bergkvist, Johan Ahlgren, Lisa Rydén, Roger Olofsson Bagge, Malin Sund, Hemming Johansson, Dan Lundstedt, on behalf of the SENOMAC Trialists’ Group

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

GABPA predicts prognosis and inhibits metastasis of hepatocellular carcinoma

Sheng Zhang, Kang Zhang, Piyou Ji, Xuqing Zheng, Jianbin Jin, Min Feng, Pingguo Liu

01.12.2017 | Technical advance | Ausgabe 1/2017 Open Access

Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium

Hisashi Hasegawa, Yoshiaki Kusumi, Takeshi Asakawa, Miyoko Maeda, Toshinori Oinuma, Tohru Furusaka, Takeshi Oshima, Mariko Esumi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Glyoxalase 1 expression is associated with an unfavorable prognosis of oropharyngeal squamous cell carcinoma

Nele Kreycy, Christiane Gotzian, Thomas Fleming, Christa Flechtenmacher, Niels Grabe, Peter Plinkert, Jochen Hess, Karim Zaoui

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Fluorescent CXCR4 targeting peptide as alternative for antibody staining in Ewing sarcoma

Laurens G. L. Sand, Tessa Buckle, Fijs W. B. van Leeuwen, Willem E. Corver, Alwine B. Kruisselbrink, Aart G. Jochemsen, Pancras C. W. Hogendoorn, Károly Szuhai

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Circulating blood levels of IL-6, IFN-γ, and IL-10 as potential diagnostic biomarkers in gastric cancer: a controlled study

Norma Sánchez-Zauco, Javier Torres, Alejandro Gómez, Margarita Camorlinga-Ponce, Leopoldo Muñoz-Pérez, Roberto Herrera-Goepfert, Rafael Medrano-Guzmán, Silvia Giono-Cerezo, Carmen Maldonado-Bernal

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Understanding why cancer patients accept or turn down psycho-oncological support: a prospective observational study including patients’ and clinicians’ perspectives on communication about distress

Diana Zwahlen, Theresa Tondorf, Sacha Rothschild, Michael T. Koller, Christoph Rochlitz, Alexander Kiss

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Calretinin as a blood-based biomarker for mesothelioma

Georg Johnen, Katarzyna Gawrych, Irina Raiko, Swaantje Casjens, Beate Pesch, Daniel G. Weber, Dirk Taeger, Martin Lehnert, Jens Kollmeier, Torsten Bauer, Arthur W. Musk, Bruce W. S. Robinson, Thomas Brüning, Jenette Creaney

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: gamma probe and ultrasound guided fine needle aspiration cytology of the sentinel node (GULF) trial - overview of the literature, pilot and study protocol

Charlotte M.C. Oude Ophuis, Lisa B. Koppert, Cécile de Monyé, Carolien H.M. van Deurzen, Senada Koljenović, Alexander C.J. van Akkooi, Cornelis Verhoef, Dirk J. Grünhagen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Combination of Helicobacter pylori infection and the interleukin 8 –251 T > A polymorphism, but not the mannose-binding lectin 2 codon 54 G > A polymorphism, might be a risk factor of gastric cancer

Young Woon Chang, Chi Hyuk Oh, Jung-Wook Kim, Jae Won Lee, Mi Ju Park, Jae-Jun Shim, Chang Kyun Lee, Jae-Young Jang, Seok Ho Dong, Hyo Jong Kim, Sung Soo Kim, Byung-Ho Kim

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

An objective nodal staging system for breast cancer patients undergoing neoadjuvant systemic treatment

Tae-Kyung Yoo, Jung Min Chang, Hee-Chul Shin, Wonshik Han, Dong-Young Noh, Hyeong-Gon Moon

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Single-cell mRNA profiling reveals transcriptional heterogeneity among pancreatic circulating tumour cells

Morten Lapin, Kjersti Tjensvoll, Satu Oltedal, Milind Javle, Rune Smaaland, Bjørnar Gilje, Oddmund Nordgård

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Preoperative Prognostic Nutritional Index is a Significant Predictor of Survival with Bladder Cancer after Radical Cystectomy: a retrospective study

Ding Peng, Yan-qing Gong, Han Hao, Zhi-song He, Xue-song Li, Cui-jian Zhang, Li-qun Zhou

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Evaluation of treatment response and resistance in metastatic renal cell cancer (mRCC) using integrated 18F–Fluorodeoxyglucose (18F–FDG) positron emission tomography/magnetic resonance imaging (PET/MRI); The REMAP study

Christian Kelly-Morland, Sarah Rudman, Paul Nathan, Susan Mallett, Giovanni Montana, Gary Cook, Vicky Goh

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Treatment patterns and real world clinical outcomes in ER+/HER2- post-menopausal metastatic breast cancer patients in the United States

Giovanni Zanotti, Matthias Hunger, Julia J Perkins, Ruslan Horblyuk, Monique Martin

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Chemotherapy-induced Takotsubo cardiomyopathy, a case report and review of the literature

Matteo Coen, Fabio Rigamonti, Arnaud Roth, Thibaud Koessler

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

CUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma

Gong -Kai Huang, Ting-Ting Liu, Shao-Wen Weng, Huey-Ling You, Yu-Ching Wei, Chang-Han Chen, Hock-Liew Eng, Wan-Ting Huang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Whole exome sequencing of an asbestos-induced wild-type murine model of malignant mesothelioma

Sophie Sneddon, Ann-Marie Patch, Ian M. Dick, Stephen Kazakoff, John V. Pearson, Nicola Waddell, Richard J. N. Allcock, Robert A. Holt, Bruce W. S. Robinson, Jenette Creaney

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A nationwide multi-institutional retrospective study to identify prognostic factors and develop a graded prognostic assessment system for patients with brain metastases from uterine corpus and cervical cancer

Nakamasa Hayashi, Hideaki Takahashi, Yuzo Hasegawa, Fumi Higuchi, Masamichi Takahashi, Keishi Makino, Masatoshi Takagaki, Jiro Akimoto, Takeshi Okuda, Yoshiko Okita, Koichi Mitsuya, Yasuyuki Hirashima, Yoshitaka Narita, Yoko Nakasu, On Behalf of the Committee of Brain Tumor Registry of Japan Supported by the Japan Neurosurgical Society

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

After accounting for competing causes of death and more advanced stage, do Aboriginal and Torres Strait Islander peoples with cancer still have worse survival? A population-based cohort study in New South Wales

Hanna E. Tervonen, Richard Walton, Hui You, Deborah Baker, David Roder, David Currow, Sanchia Aranda

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Potential mechanisms of resistance to venetoclax and strategies to circumvent it

Stephen K. Tahir, Morey L. Smith, Paul Hessler, Lisa Roberts Rapp, Kenneth B. Idler, Chang H. Park, Joel D. Leverson, Lloyd T. Lam

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial

Camilla K. Lonkvist, Simon Lønbro, Anders Vinther, Bo Zerahn, Eva Rosenbom, Hanne Primdahl, Pernille Hojman, Julie Gehl

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

ICORG 10-14: NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study (Neo-AEGIS)

JV Reynolds, SR Preston, B O’Neill, L Baeksgaard, SM Griffin, C Mariette, S Cuffe, M Cunningham, T Crosby, I Parker, K Hofland, G Hanna, LB Svendsen, CL Donohoe, C Muldoon, D O’Toole, C Johnson, N Ravi, G Jones, AK Corkhill, M Illsley, J Mellor, K Lee, M Dib, V Marchesin, M Cunnane, K Scott, P Lawner, S Warren, S O’Reilly, G O’Dowd, G Leonard, B Hennessy, R Mc Dermott

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Most children with cancer are not enrolled on a clinical trial in Canada: a population-based study

Jason D. Pole, Randy Barber, Rose-Émilie Bergeron, Anne Sophie Carret, David Dix, Ketan Kulkarni, Emilie Martineau, Alicia Randall, David Stammers, Caron Strahlendorf, Douglas R. Strother, Tony H. Truong, Lillian Sung

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The prognostic significance of KRAS and BRAF mutation status in Korean colorectal cancer patients

Daeyoun David Won, Jae Im Lee, In Kyu Lee, Seong-Taek Oh, Eun Sun Jung, Sung Hak Lee

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The peripheral monocyte count is associated with the density of tumor-associated macrophages in the tumor microenvironment of colorectal cancer: a retrospective study

Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shigetomi Nakao, Shinji Matsutani, Kosei Hirakawa, Masaichi Ohira

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Lipodox® (generic doxorubicin hydrochloride liposome injection): in vivo efficacy and bioequivalence versus Caelyx® (doxorubicin hydrochloride liposome injection) in human mammary carcinoma (MX-1) xenograft and syngeneic fibrosarcoma (WEHI 164) mouse models

Vinod Burade, Subhas Bhowmick, Kuntal Maiti, Rishit Zalawadia, Harry Ruan, Rajamannar Thennati

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Is detection of intraperitoneal exfoliated tumor cells after surgical resection of rectal cancer a prognostic factor of survival?

Christian Arstad, Paulo Refinetti, Annette Torgunrud Kristensen, Karl-Erik Giercksky, Per Olaf Ekstrøm

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Phase I study of oral ridaforolimus in combination with paclitaxel and carboplatin in patients with solid tumor cancers

Hye Sook Chon, Sokbom Kang, Jae K. Lee, Sachin M. Apte, Mian M. Shahzad, Irene Williams-Elson, Robert M. Wenham

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

TRIBE-2: a phase III, randomized, open-label, strategy trial in unresectable metastatic colorectal cancer patients by the GONO group

Chiara Cremolini, Federica Marmorino, Fotios Loupakis, Gianluca Masi, Carlotta Antoniotti, Lisa Salvatore, Marta Schirripa, Luca Boni, Vittorina Zagonel, Sara Lonardi, Giuseppe Aprile, Emiliano Tamburini, Vincenzo Ricci, Monica Ronzoni, Filippo Pietrantonio, Chiara Valsuani, Gianluca Tomasello, Alessandro Passardi, Giacomo Allegrini, Samantha Di Donato, Daniele Santini, Alfredo Falcone, on behalf of all the investigators of the Gruppo Oncologico del Nord Ovest

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma

Chi Wai Yip, Ching Yan Lam, Terence C. W. Poon, Tan To Cheung, Phyllis F. Y. Cheung, Sze Wai Fung, Xiao Qi Wang, Idy C.Y. Leung, Linda W. C. Ng, Chung Mau Lo, George S. W. Tsao, Siu Tim Cheung

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic factors and outcome of Liposarcoma patients: a retrospective evaluation over 15 years

Carolin Knebel, Ulrich Lenze, Florian Pohlig, Florian Lenze, Norbert Harrasser, Christian Suren, Jonathan Breitenbach, Hans Rechl, Rüdiger von Eisenhart-Rothe, Heinrich M. L. Mühlhofer

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Antiangiogenic agents targeting different angiogenic pathways have opposite effects on tumor hypoxia in R-18 human melanoma xenografts

Jon-Vidar Gaustad, Trude G. Simonsen, Lise Mari K. Andersen, Einar K. Rofstad

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Pooled safety analyses of ALK-TKI inhibitor in ALK-positive NSCLC

Qian Zhu, Hao Hu, De-Sheng Weng, Xiao-Fei Zhang, Chang-Long Chen, Zi-Qi Zhou, Yan Tang, Jian-Chuan Xia

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Internet-based perioperative exercise program in patients with Barrett’s carcinoma scheduled for esophagectomy [iPEP - study] a prospective randomized-controlled trial

Daniel Pfirrmann, Suzan Tug, Oana Brosteanu, Matthias Mehdorn, Martin Busse, Peter P. Grimminger, Florian Lordick, Torben Glatz, Jens Hoeppner, Hauke Lang, Perikles Simon, Ines Gockel

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Reduced RCE1 expression predicts poor prognosis of colorectal carcinoma

Boyun Shi, Xinke Zhou, Lu He, Min Liang, Yuanwei Luo, Peng Jiang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Patterns of venous thromboembolism risk in patients with localized colorectal cancer undergoing adjuvant chemotherapy or active surveillance: an observational cohort study

Jakob Michael Riedl, Florian Posch, Angelika Bezan, Joanna Szkandera, Maria Anna Smolle, Thomas Winder, Christopher H. Rossmann, Renate Schaberl-Moser, Martin Pichler, Michael Stotz, Herbert Stöger, Armin Gerger

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Effect of transcutaneous electrical stimulation treatment on lower urinary tract symptoms after class III radical hysterectomy in cervical cancer patients: study protocol for a multicentre, randomized controlled trial

Xiu-Li Sun, Hai-Bo Wang, Zhi-Qi Wang, Ting-ting Cao, Xin Yang, Jing-Song Han, Yang-feng Wu, Kathleen H. Reilly, Jian-Liu Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Serial immunomonitoring of cancer patients receiving combined antagonistic anti-CD40 and chemotherapy reveals consistent and cyclical modulation of T cell and dendritic cell parameters

Alison M. McDonnell, Alistair Cook, Bruce W. S. Robinson, Richard A. Lake, Anna K. Nowak

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors

Eric Leung, Rob A. Cairns, Naz Chaudary, Ravi N. Vellanki, Tuula Kalliomaki, Eduardo H. Moriyama, Hilda Mujcic, Brian C. Wilson, Bradly G. Wouters, Richard Hill, Michael Milosevic

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic impact of blood and urinary angiogenic factor levels at diagnosis and during treatment in patients with osteosarcoma: a prospective study

Marie-Dominique Tabone, Laurence Brugières, Sophie Piperno-Neumann, Marie-Ange Selva, Perrine Marec-Bérard, Hélène Pacquement, Cyril Lervat, Nadège Corradini, Jean-Claude Gentet, Rémy Couderc, Aurélie Chevance, Céline Mahier-Ait Oukhatar, Natacha Entz-Werle, Jean-Yves Blay, Marie-Cecile Le Deley

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group – EWING1

Ricardo G. Becker, Lauro J. Gregianin, Carlos R. Galia, Reynaldo Jesus-Garcia Filho, Eduardo A. Toller, Gerardo Badell, Suely A. Nakagawa, Alexandre David, André M. Baptista, Eduardo S. Yonamime, Osvaldo A. Serafini, Valter Penna, Julie Francine C. Santos, Algemir L. Brunetto, On behalf of the Brazilian Collaborative Study Group of Ewing Family of Tumors – EWING1 and the Brazilian Society of Pediatric Oncology – SOBOPE

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The dose-response relationship between tobacco smoking and the risk of lymphomas: a case-control study

Martina Taborelli, Maurizio Montella, Massimo Libra, Rosamaria Tedeschi, Anna Crispo, Maria Grimaldi, Luigino Dal Maso, Diego Serraino, Jerry Polesel

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Characterization of MicroRNA-200 pathway in ovarian cancer and serous intraepithelial carcinoma of fallopian tube

Junzheng Yang, Yilan Zhou, Shu-Kay Ng, Kuan-Chun Huang, Xiaoyan Ni, Pui-Wah Choi, Kathleen Hasselblatt, Michael G. Muto, William R. Welch, Ross S. Berkowitz, Shu-Wing Ng

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Breast cancer patient delay in Fukushima, Japan following the 2011 triple disaster: a long-term retrospective study

Akihiko Ozaki, Shuhei Nomura, Claire Leppold, Masaharu Tsubokura, Tetsuya Tanimoto, Takeru Yokota, Shigehira Saji, Toyoaki Sawano, Manabu Tsukada, Tomohiro Morita, Sae Ochi, Shigeaki Kato, Masahiro Kami, Tsuyoshi Nemoto, Yukio Kanazawa, Hiromichi Ohira

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Anaplastic astrocytoma mimicking progressive multifocal leucoencephalopathy: a case report and review of the overlapping syndromes

Ema Kantorová, Michal Bittšanský, Štefan Sivák, Eva Baranovičová, Petra Hnilicová, Vladimír Nosáľ, Daniel Čierny, Kamil Zeleňák, Wolfgang Brück, Egon Kurča

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

A phase 2 randomized trial to evaluate the impact of a supervised exercise program on cardiotoxicity at 3 months in patients with HER2 overexpressing breast cancer undergoing adjuvant treatment by trastuzumab: design of the CARDAPAC study

Quentin Jacquinot, Nathalie Meneveau, Marion Chatot, Franck Bonnetain, Bruno Degano, Malika Bouhaddi, Gilles Dumoulin, Dewi Vernerey, Xavier Pivot, Fabienne Mougin

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

African-American esophageal squamous cell carcinoma expression profile reveals dysregulation of stress response and detox networks

Hayriye Verda Erkizan, Kory Johnson, Svetlana Ghimbovschi, Deepa Karkera, Gregory Trachiotis, Houtan Adib, Eric P. Hoffman, Robert G. Wadleigh

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Strain elastography imaging for early detection and prediction of tumor response to concurrent chemo-radiotherapy in locally advanced cervical cancer: feasibility study

Yan Xu, Lijing Zhu, Baorui Liu, Tong Ru, Huanhuan Wang, Jian He, Song Liu, Xiaofeng Yang, Zhengyang Zhou, Tian Liu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Droplet digital PCR for detection and quantification of circulating tumor DNA in plasma of head and neck cancer patients

Joost H. van Ginkel, Manon M. H. Huibers, Robert J. J. van Es, Remco de Bree, Stefan M. Willems

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Personalised informed choice on evidence and controversy on mammography screening: study protocol for a randomized controlled trial

Anna Roberto, Cinzia Colombo, Giulia Candiani, Livia Giordano, Paola Mantellini, Eugenio Paci, Roberto Satolli, Mario Valenza, Paola Mosconi

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Retinal and vitreous metastases from hepatocholangiocarcinoma

Anna Praidou, Sarita Jacob, Luciane Irion, Ramesh Sivaraj, Carl Groenewald, Sarah E. Coupland, Heinrich Heimann

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis

Nhi Huynh, Kai Wang, Mildred Yim, Chelsea J. Dumesny, Mauro S. Sandrin, Graham S. Baldwin, Mehrdad Nikfarjam, Hong He

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Protein kinase C-α (PKCα) modulates cell apoptosis by stimulating nuclear translocation of NF-kappa-B p65 in urothelial cell carcinoma of the bladder

Jin Zheng, Chuize Kong, Xiaoxi Yang, Xiaolu Cui, Xuyong Lin, Zhe Zhang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Utility of the sentinel node concept for detection of lateral pelvic lymph node metastasis in lower rectal cancer

Shigehiro Yanagita, Yoshikazu Uenosono, Takaaki Arigami, Yoshiaki Kita, Shinichiro Mori, Shoji Natsugoe

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma

Anderson H. Webb, Bradley T. Gao, Zachary K. Goldsmith, Andrew S. Irvine, Nabil Saleh, Ryan P. Lee, Justin B. Lendermon, Rajini Bheemreddy, Qiuhua Zhang, Rachel C. Brennan, Dianna Johnson, Jena J. Steinle, Matthew W. Wilson, Vanessa M. Morales-Tirado

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

HPV and cofactors for invasive cervical cancer in Morocco: a multicentre case-control study

Mohamed Berraho, Afaf Amarti-Riffi, Mohammed El-Mzibri, Rachid Bezad, Noureddine Benjaafar, Abdelatif Benideer, Noureddine Matar, Zinab Qmichou, Naima Abda, Mohammed Attaleb, Kaoutar Znati, Hind El Fatemi, Karima Bendahhou, Majdouline Obtel, Abdelhai Filali Adib, Simone Mathoulin-Pelissier, Chakib Nejjari

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Curative resection by splenectomy for solitary splenic metastasis from early gastric cancer: a case report and literature review

Junichi Yoshizawa, Naoki Kubo, Satoshi Ishizone, Fumitoshi Karasawa, Ataru Nakayama

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Examination of multiple UGT1A and DPYD polymorphisms has limited ability to predict the toxicity and efficacy of metastatic colorectal cancer treated with irinotecan-based chemotherapy: a retrospective analysis

Dan Liu, Jian Li, Jing Gao, Yanyan Li, Rui Yang, Lin Shen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Current guidelines for BRCA testing of breast cancer patients are insufficient to detect all mutation carriers

Eli Marie Grindedal, Cecilie Heramb, Inga Karsrud, Sarah Louise Ariansen, Lovise Mæhle, Dag Erik Undlien, Jan Norum, Ellen Schlichting

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Cerebellar mutism syndrome in children with brain tumours of the posterior fossa

Morten Wibroe, Johan Cappelen, Charlotte Castor, Niels Clausen, Pernilla Grillner, Thora Gudrunardottir, Ramneek Gupta, Bengt Gustavsson, Mats Heyman, Stefan Holm, Atte Karppinen, Camilla Klausen, Tuula Lönnqvist, René Mathiasen, Pelle Nilsson, Karsten Nysom, Karin Persson, Olof Rask, Kjeld Schmiegelow, Astrid Sehested, Harald Thomassen, Ingrid Tonning-Olsson, Barbara Zetterqvist, Marianne Juhler

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A rapid and quantitative method to detect human circulating tumor cells in a preclinical animal model

Shih-Hsin Tu, Yi-Chen Hsieh, Li-Chi Huang, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Chia-Hwa Lee

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas

KyuHo Lee, Kyoung-Bun Lee, Hae Yoen Jung, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Ja-June Jang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Acute myeloid leukemia and pregnancy: clinical experience from a single center and a review of the literature

Nicola Stefano Fracchiolla, Mariarita Sciumè, Francesco Dambrosi, Francesca Guidotti, Manuela Wally Ossola, Giovanna Chidini, Umberto Gianelli, Daniela Merlo, Agostino Cortelezzi

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Solitary plasmacytoma: population-based analysis of survival trends and effect of various treatment modalities in the USA

Nishitha Thumallapally, Ahmed Meshref, Mohammed Mousa, Terenig Terjanian

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Within-class differences in cancer risk for sulfonylurea treatments in patients with type 2 diabetes (ZODIAC-55) – a study protocol

Dennis Schrijnders, Geertruida H. de Bock, Sebastiaan T. Houweling, Kornelis J. J. van Hateren, Klaas H. Groenier, Jeffrey A. Johnson, Henk J. G. Bilo, Nanne Kleefstra, Gijs W. D. Landman

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Clinical outcomes of transoral videolaryngoscopic surgery for hypopharyngeal and supraglottic cancer

Yorihisa Imanishi, Hiroyuki Ozawa, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Mariko Sekimizu, Fumihiro Ito, Toshiki Tomita, Kaoru Ogawa

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Development of a computer-tailored physical activity intervention for prostate and colorectal cancer patients and survivors: OncoActive

R. H. J. Golsteijn, C. Bolman, E. Volders, D. A. Peels, H. de Vries, L. Lechner

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration

Princy Parsana, Sarah R. Amend, James Hernandez, Kenneth J. Pienta, Alexis Battle

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

The effect of geriatric intervention in frail elderly patients receiving chemotherapy for colorectal cancer: a randomized trial (GERICO)

C. M. Lund, K. K. Vistisen, C. Dehlendorff, F. Rønholt, J. S. Johansen, D. L. Nielsen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis

Xinfang Yu, Wei Li, Zhenkun Xia, Li Xie, Xiaolong Ma, Qi Liang, Lijun Liu, Jian Wang, Xinmin Zhou, Yifeng Yang, Haidan Liu

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

CMISG1701: a multicenter prospective randomized phase III clinical trial comparing neoadjuvant chemoradiotherapy to neoadjuvant chemotherapy followed by minimally invasive esophagectomy in patients with locally advanced resectable esophageal squamous cell carcinoma (cT3-4aN0-1M0) (NCT03001596)

Han Tang, Lijie Tan, Yaxing Shen, Hao Wang, Miao Lin, Mingxiang Feng, Songtao Xu, Weigang Guo, Cheng Qian, Tianshu Liu, Zhaochong Zeng, Yingyong Hou, Zhentao Yu, Hongjing Jiang, Zhigang Li, Chun Chen, Changhong Lian, Ming Du, Hecheng Li, Deyao Xie, Jun Yin, Naiqing Zhao, Qun Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prognostic and predictive factors in patients with metastatic or recurrent cervical cancer treated with platinum-based chemotherapy.

Sofia Karageorgopoulou, Ioannis D. Kostakis, Maria Gazouli, Sonia Markaki, Marios Papadimitriou, Evangelos Bournakis, Meletios-Athanassios Dimopoulos, Christos A Papadimitriou

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

E3 ubiquitin ligase, RNF139, inhibits the progression of tongue cancer

Lina Wang, Wei Yin, Chun Shi

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

A phase II randomized trial of Observation versus stereotactic ablative RadiatIon for OLigometastatic prostate CancEr (ORIOLE)

Noura Radwan, Ryan Phillips, Ashley Ross, Steven P. Rowe, Michael A. Gorin, Emmanuel S. Antonarakis, Curtiland Deville, Stephen Greco, Samuel Denmeade, Channing Paller, Daniel Y. Song, Maximilian Diehn, Hao Wang, Michael Carducci, Kenneth J. Pienta, Martin G. Pomper, Theodore L. DeWeese, Adam Dicker, Mario Eisenberger, Phuoc T. Tran

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Robot-assisted radical prostatectomy significantly reduced biochemical recurrence compared to retro pubic radical prostatectomy

Tetsuya Fujimura, Hiroshi Fukuhara, Satoru Taguchi, Yuta Yamada, Toru Sugihara, Tohru Nakagawa, Aya Niimi, Haruki Kume, Yasuhiko Igawa, Yukio Homma

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Dickkopf-4 is frequently overexpressed in epithelial ovarian carcinoma and promotes tumor invasion

Shizhuo Wang, Heng Wei, Shulan Zhang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The role of hormonal therapy in patients with relapsed high-grade ovarian carcinoma: a retrospective series of tamoxifen and letrozole

Angela George, Jennifer McLachlan, Nina Tunariu, Chiara Della Pepa, Cristina Migali, Martin Gore, Stan Kaye, Susana Banerjee

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Precision oncology using a limited number of cells: optimization of whole genome amplification products for sequencing applications

Shonan Sho, Colin M. Court, Paul Winograd, Sangjun Lee, Shuang Hou, Thomas G. Graeber, Hsian-Rong Tseng, James S. Tomlinson

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

miRNome landscape analysis reveals a 30 miRNA core in retinoblastoma

Blanca Elena Castro-Magdonel, Manuela Orjuela, Javier Camacho, Adda Jeanette García-Chéquer, Lourdes Cabrera-Muñoz, Stanislaw Sadowinski-Pine, Noé Durán-Figueroa, María de Jesús Orozco-Romero, Ana Claudia Velázquez-Wong, Adriana Hernández-Ángeles, Claudia Hernández-Galván, Citlali Lara-Molina, M. Verónica Ponce-Castañeda

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013-08)

L. M. van Roozendaal, M. L. G. Vane, T. van Dalen, J. A. van der Hage, L. J. A. Strobbe, L. J. Boersma, S. C. Linn, M. B. I. Lobbes, P. M. P. Poortmans, V. C. G. Tjan-Heijnen, K. K. B. T. Van de Vijver, J. de Vries, A. H. Westenberg, A. G. H. Kessels, J. H. W. de Wilt, M. L. Smidt

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex

Louisa M. Salemi, Matthew E. R. Maitland, Eyal R. Yefet, Caroline Schild-Poulter

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

A randomized double-blind study of testosterone replacement therapy or placebo in testicular cancer survivors with mild Leydig cell insufficiency (Einstein-intervention)

Mikkel Bandak, Niels Jørgensen, Anders Juul, Jakob Lauritsen, Michael Kreiberg, Peter Sandor Oturai, Jørn Wulff Helge, Gedske Daugaard

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A multicenter survey of first-line treatment patterns and gene aberration test status of patients with unresectable Stage IIIB/IV nonsquamous non-small cell lung cancer in China (CTONG 1506)

Qing Zhou, Yong Song, Xin Zhang, Gong-Yan Chen, Dian-Sheng Zhong, Zhuang Yu, Ping Yu, Yi-Ping Zhang, Jian-Hua Chen, Yi Hu, Guo-Sheng Feng, Xia Song, Qiang Shi, Lu Lu Yang, Ping Hai Zhang, Yi-Long Wu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression

Delores J. Grant, Zinan Chen, Lauren E. Howard, Emily Wiggins, Amanda De Hoedt, Adriana C. Vidal, Skyla T. Carney, Jill Squires, Clara E. Magyar, Jiaoti Huang, Stephen J. Freedland

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Risk stratification system to predict recurrence of intrahepatic cholangiocarcinoma after hepatic resection

Seogsong Jeong, Qingbao Cheng, Lifeng Huang, Jian Wang, Meng Sha, Ying Tong, Lei Xia, Longzhi Han, Zhifeng Xi, Jianjun Zhang, Xiaoni Kong, Jinyang Gu, Qiang Xia

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Study protocol: multi-parametric magnetic resonance imaging for therapeutic response prediction in rectal cancer

Trang Thanh Pham, Gary Liney, Karen Wong, Robba Rai, Mark Lee, Daniel Moses, Christopher Henderson, Michael Lin, Joo-Shik Shin, Michael Bernard Barton

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Effects of an interactive mHealth innovation for early detection of patient-reported symptom distress with focus on participatory care: protocol for a study based on prospective, randomised, controlled trials in patients with prostate and breast cancer

Ann Langius-Eklöf, Marie-Therése Crafoord, Mats Christiansen, Maria Fjell, Kay Sundberg

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Methionyl-tRNA synthetase overexpression is associated with poor clinical outcomes in non-small cell lung cancer

Eun Young Kim, Ji Ye Jung, Arum Kim, Kwangsoo Kim, Yoon Soo Chang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

A comprehensive overview on the surgical management of secondary lymphedema of the upper and lower extremities related to prior oncologic therapies

Ramon Garza III, Roman Skoracki, Karen Hock, Stephen P. Povoski

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer

Olafur Andri Stefansson, Stefan Hermanowicz, Jasper van der Horst, Holmfridur Hilmarsdottir, Zuzanna Staszczak, Jon Gunnlaugur Jonasson, Laufey Tryggvadottir, Thorkell Gudjonsson, Stefan Sigurdsson

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Evolution of educational inequalities in site-specific cancer mortality among Belgian men between the 1990s and 2000s using a “fundamental cause” perspective

Katrien Vanthomme, Hadewijch Vandenheede, Paulien Hagedoorn, Sylvie Gadeyne

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

ALK-rearranged lung squamous cell carcinoma responding to alectinib: a case report and review of the literature

Nobuaki Mamesaya, Kazuhisa Nakashima, Tateaki Naito, Takashi Nakajima, Masahiro Endo, Toshiaki Takahashi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

MALDI-TOF-MS analysis in discovery and identification of serum proteomic patterns of ovarian cancer

Agata Swiatly, Agnieszka Horala, Joanna Hajduk, Jan Matysiak, Ewa Nowak-Markwitz, Zenon J. Kokot

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Regulation of early growth response 2 expression by secreted frizzled related protein 1

Kelly J. Gregory, Stephanie M. Morin, Sallie S. Schneider

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The effects of the location of cancer stem cell marker CD133 on the prognosis of hepatocellular carcinoma patients

Yao-Li Chen, Ping-Yi Lin, Ying-Zi Ming, Wei-Chieh Huang, Rong-Fu Chen, Po-Ming Chen, Pei-Yi Chu

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Multiparametric magnetic resonance imaging in mucosal primary head and neck cancer: a prospective imaging biomarker study

Christopher N Rumley, Mark T Lee, Lois Holloway, Robba Rai, Myo Min, Dion Forstner, Allan Fowler, Gary Liney

01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

Communication about uncertainty and hope: A randomized controlled trial assessing the efficacy of a communication skills training program for physicians caring for cancer patients

Yves Libert, Livia Peternelj, Isabelle Bragard, Aurore Liénard, Isabelle Merckaert, Christine Reynaert, Darius Razavi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

JMJD2A promotes the Warburg effect and nasopharyngeal carcinoma progression by transactivating LDHA expression

Yi Su, Qiu-hong Yu, Xiang-yun Wang, Li-ping Yu, Zong-feng Wang, Ying-chun Cao, Jian-dong Li