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01.09.2015 | Clinical

Clinical translation for endometrial cancer stem cells hypothesis

verfasst von: Maria João Carvalho, Mafalda Laranjo, Ana Margarida Abrantes, Isabel Torgal, Maria Filomena Botelho, Carlos Freire Oliveira

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 3/2015

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Abstract

Endometrial cancer is the most frequent gynecological malignancy in developed world. Cancer stem cells (CSC) are recognized as a small proportion of cells among the tumor cell population that are capable of self-renewal, aberrant differentiation, and escape homeostasis. This review aims to systematize the existing evidence of CSC of endometrial cancer and its clinical translation. In endometrial cancer, the cancer stem cell hypothesis has been studied in vitro using the isolation of colony forming units, side population with dye efflux capacity, and tumorospheres. The stem cell markers for endometrial cancer do not have uniform characteristics, albeit CD133 and aldehyde dehydrogenase (ALDH) were being associated with CSC phenotype. The application of endometrial CSC on xenograft models proves the tumorigenic capacity of this small group of cells. The metastatic process has been explained due to epithelial-mesenchymal transition (EMT) in which CSC seems to have a critical role. The chemoresistance is characteristic of CSC that in endometrial cancer has been shown in CSC phenotype and associated with CSC markers. The most ambitious potential for CSC is the development of targeted therapies. Its application on endometrial cancer is still poor, being a future perspective for research.

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Titel: Clinical translation for endometrial cancer stem cells hypothesis
verfasst von: Maria João Carvalho
Mafalda Laranjo
Ana Margarida Abrantes
Isabel Torgal
Maria Filomena Botelho
Carlos Freire Oliveira
Publikationsdatum: 01.09.2015
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 3/2015
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-015-9574-0

Springer Medizin

Clinical translation for endometrial cancer stem cells hypothesis

Abstract

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Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

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Springer Medizin

Abstract

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