What is Known:
• Congenital adrenal hyperplasia (CAH) is a group of inherited impairment of cortisol biosynthesis.
• Studies of cognitive function in patients with congenital adrenal hyperplasia (CAH) are few and controversial.
What is New:
• Children with CAH may have lower intelligent quotient (IQ) and cognitive deficits.
• Early hyponatremic episodes, overtreatment with glucocorticoids, and high androgen levels may be possible causative factors for the cognitive deficits.