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Erschienen in: Cancer and Metastasis Reviews 3/2020

23.05.2020 | Metastasis

Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis

verfasst von: Ana C. Martins Cavaco, Sara Dâmaso, Sandra Casimiro, Luís Costa

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 3/2020

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Abstract

Progression through dissemination to tumor-surrounding tissues and metastasis development is a hallmark of cancer that requires continuous cell-to-cell interactions and tissue remodeling. In fact, metastization can be regarded as a tissue disease orchestrated by cancer cells, leading to neoplastic colonization of new organs. Collagen is a major component of the extracellular matrix (ECM), and increasing evidence suggests that it has an important role in cancer progression and metastasis. Desmoplasia and collagen biomarkers have been associated with relapse and death in cancer patients. Despite the increasing interest in ECM and in the desmoplastic process in tumor microenvironment as prognostic factors and therapeutic targets in cancer, further research is required for a better understanding of these aspects of cancer biology. In this review, published evidence correlating collagen with cancer prognosis is retrieved and analyzed, and the role of collagen and its fragments in cancer pathophysiology is discussed.
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Metadaten
Titel
Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis
verfasst von
Ana C. Martins Cavaco
Sara Dâmaso
Sandra Casimiro
Luís Costa
Publikationsdatum
23.05.2020
Verlag
Springer US
Schlagwörter
Metastasis
Collagen
Erschienen in
Cancer and Metastasis Reviews / Ausgabe 3/2020
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-020-09888-5

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