Background
Results
Marker | Origin | Type | Description | References |
---|---|---|---|---|
CD274 | RNA | Single gene | Programmed death 1 ligand 1 | [21] |
Mutational load | DNA | Nr. mutations | Absolute number of mutations in WES | |
IFN-y (reduced set) | RNA | Gene set | Interferon gamma reduced set | [9] |
IFN-y (expanded set) | RNA | Gene set | Interferon gamma reduced set | [9] |
IPS | RNA | Algorithm | Immunophenoscore | [6] |
PDCD1 | RNA | Single gene | Programmed death 1 | [23] |
POLE | RNA | Single gene | DNA polymerase epsilon, catalytic subunit | [11] |
POLE2 | RNA | Single gene | DNA polymerase epsilon 2, accessory subunit | [11] |
POLE3 | RNA | Single gene | DNA polymerase epsilon 3, accessory subunit | [11] |
POLE4 | RNA | Single gene | DNA polymerase epsilon 4, accessory subunit | [11] |
CTLA4 | RNA | Single gene | Cytotoxic T-lymphocyte associated protein 4 | [25] |
PDCD1LG2 | RNA | Single gene | Programmed cell death 1 ligand 2 | [24] |
ICB resist. signature 1 | RNA | Gene set | Epithelial–mesenchymal transition signature 1 | [7] |
ICB resist. signature 2 | RNA | Gene set | Epithelial–mesenchymal transition signature 2 | [17] |
ICB resist. signature 3 | RNA | Gene set | Epithelial–mesenchymal transition signature 3 | [18] |
AXL pathway | RNA | Gene set | AXL receptor tyrosine kinase pathway | [19] |
AXL | RNA | Single gene | AXL receptor tyrosine kinase | [19] |
TIDE | RNA | Algorithm | Tumor immune dysfunction and exclusion | [12] |
IFN-y (reduced set)
|
CXCL10, CXCL9, HLA-DRA, IDO1, IFNG, STAT1 |
IFN-y (expanded set)
|
CCL5, CD2, CD3D, CD3E, CIITA, CXCL10, CXCL13, CXCR6, GZMB, GZMK, HLA-DRA, HLA-E, IDO1, IL2RG, LAG3, NKG7, STAT1, TAGAP |
ImmunoPhenoScore (IPS)
|
ACAP1, ADRM1, AHSA1, AIM2, APOL3, ARHGAP10, ATM, ATP10D, B2 M, BIRC3, BRIP1, C1GALT1C1, C3AR1, CASP3, CASQ1, CCL20, CCL3L1, CCL4, CCL5, CCNB1, CCR2, CCR5, CCR7, CCT6B, CD14, CD160, CD2, CD27, CD274, CD300E, CD37, CD3D, CD3E, CD3G, CD55, CD69, CD72, CD86, CD8A, CETN3, CFLAR, CLEC5A, CMKLR1, CSE1L, CTLA4, CXCR4, DAPP1, DARS, DOCK9, DUSP2, ESCO2, ETS1, EXO1, EXOC6, EXOSC9, EZH2, FCGR2A, FCGR2B, FCGR3A, FCRL6, FERMT3, FLT3LG, FOXP3, GDE1, GEMIN6, GNLY, GPSM3, GPT2, GZMA, GZMH, GZMK, GZMM, HAPLN3, HAVCR2, HLA-A, HLA-B, HLA-C, HLA-DMB, HLA-DPA1, HLA-DPA1, HLA-DPB1, HLA-DPB1, HLA-E, HLA-F, IARS, ICOS, IDO1, IFI16, IL18BP, IL2RB, IL34, IL4R, ITGA4, ITGAL, ITGAM, KIF11, KNTC1, L1CAM, LAG3, LCK, LIME1, LIPA, LRP1, LRRC42, LTK, MARCO, MMP12, MNDA, MPZL1, MRC1, MS4A6A, NCOA4, NEFL, NFKBIA, NKG7, NUF2, PARVG, PDCD1, PDCD1LG2, PDGFRL, PELO, PIK3IP1, PLEK, PRC1, PRSS23, PSAP, PSAT1, PTGER2, PTGES2, PTGIR, PTGS1, PTRH2, REPS1, RGS1, RTKN2, S100A8, S100A9, SAMSN1, SCG2, SDPR, SELL, SETD7, SIGLEC14, SIGLEC6, SIK1, ST8SIA4, STAB 1, TAL1, TAP1, TAP2, TFEC, TIGIT, TIMM13, TIPIN, TPK1, TRAT1, TRIB2, UQCRB, USP9Y, WIPF1, ZAP70, ZCRB1 |
ICB resistance signature 1
|
ADAMTS7, AXL, COL12A1, COL8A1, FAP, FBLN1, INHBA, LOXL2, MMP1, MMP13, ROR2, TAGLN, TWIST2, WNT5A |
ICB resistance signature 2
|
CNN1, COL3A1, MXRA7, SERPINF2 |
ICB resistance signature 3
|
CST2, LAMA3 |
AXL pathway
|
AXL, FLT1, FLT4, GAS6, KDR, MERTK, MET, RET, TEK, TYRO3 |