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24.04.2019 | Original Article

Combinatory effects of vaccinia virus VG9 and the STAT3 inhibitor Stattic on cancer therapy

verfasst von: Runlin Yang, Lizhen Wang, Jie Sheng, Qianhuan Huang, Donghui Pan, Yuping Xu, Junjie Yan, Xinyu Wang, Ziyue Dong, Min Yang

Erschienen in: Archives of Virology | Ausgabe 7/2019

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Abstract

The recombinant vaccinia virus VG9 and the STAT3 inhibitor Stattic were combined to kill cancer cells via both oncolytic activity and inhibition of STAT3 phosphorylation in cells. The combinatory anti-tumour activity of these compounds was superior to the activity of VG9 or Stattic alone in vivo. The inhibition of tumour growth occurred via increased apoptosis and autophagy pathways. Furthermore, the combinatory anti-tumour activity was more efficient than that of VG9 or Stattic alone on xenografts, especially in nude mice.

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Titel: Combinatory effects of vaccinia virus VG9 and the STAT3 inhibitor Stattic on cancer therapy
verfasst von: Runlin Yang
Lizhen Wang
Jie Sheng
Qianhuan Huang
Donghui Pan
Yuping Xu
Junjie Yan
Xinyu Wang
Ziyue Dong
Min Yang
Publikationsdatum: 24.04.2019
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 7/2019
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-019-04257-2

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