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Journal of Cancer Research and Clinical Oncology

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01.03.2013 | Original Paper

Combined bendamustine, prednisone and bortezomib (BPV) in patients with relapsed or refractory multiple myeloma

verfasst von: Wolfram Pönisch, Malvina Bourgeois, Barbara Moll, Simone Heyn, Nadja Jäkel, Ina Wagner, Robert Rohrberg, Hans-Jürgen Hurtz, Marion Schmalfeld, Michael Aßmann, Thomas Edelmann, Martin Mohren, Franz Albert Hoffmann, Cornelia Becker, Andreas Schwarzer, Uta Schönfelder, Thomas Zehrfeld, Gerald Hensel, Kerstin Löschcke, Rainer Krahl, Haifa Al Ali, Dietger Niederwieser

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 3/2013

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Abstract

Introduction

Bortezomib (Velcade^®) is a proteasome inhibitor that has shown important clinical efficacy either as a single agent or in combination with other cytostatic agents in multiple myeloma (MM). In the present protocol, bortezomib was combined with other active substances like bendamustine and prednisone (BPV), in order to assess the efficacy and toxicity of the combination therapy in patients with relapsed or refractory MM.

Methods

Between January 2005 and December 2011, 78 patients with relapsed or refractory MM were treated with bendamustine 60 (−120) mg/m² on days 1 and 2, bortezomib 1.3 mg/m² on days 1, 4, 8 and 11, and prednisone 100 mg on days 1, 2, 4, 8 and 11. The median number of prior therapies was 2 with a wide range of 1–9. Thirty-three patients had pre-existing severe thrombocytopenia and/or neutropenia (WHO grade 3 or 4).

Results

A median number of two (range 1–7) BPV treatment cycles were given to the patients. The majority of the patients (n = 54; 69 %) responded after at least one cycle of chemotherapy with 3 CR, 10 nCR, 10 VGPR and 31 PR. Median PFS and OS for patients without severe hematological toxicities due to previous treatments (n = 45) were 11 and 50 months, respectively. Outcome for these patients was significantly better than that for patients with severe hematological toxicities (grade 3 or 4, n = 33) with a PFS, and OS of 3 months (p < 0.05) and 5 months (p < 0.001), respectively. The regimen was well tolerated with few significant side effects in patients without severe hematological toxicities due to previous treatments.

Summary

These results indicate that the combination of bortezomib, bendamustine and prednisone is well tolerated in patients with relapsed or refractory MM.

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Titel: Combined bendamustine, prednisone and bortezomib (BPV) in patients with relapsed or refractory multiple myeloma
verfasst von: Wolfram Pönisch
Malvina Bourgeois
Barbara Moll
Simone Heyn
Nadja Jäkel
Ina Wagner
Robert Rohrberg
Hans-Jürgen Hurtz
Marion Schmalfeld
Michael Aßmann
Thomas Edelmann
Martin Mohren
Franz Albert Hoffmann
Cornelia Becker
Andreas Schwarzer
Uta Schönfelder
Thomas Zehrfeld
Gerald Hensel
Kerstin Löschcke
Rainer Krahl
Haifa Al Ali
Dietger Niederwieser
Publikationsdatum: 01.03.2013
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 3/2013
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-012-1339-3

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Combined bendamustine, prednisone and bortezomib (BPV) in patients with relapsed or refractory multiple myeloma