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21.07.2021 | Original Article

Combined local treatments for vertebral metastases with limited epidural extension

verfasst von: Khaled Madani, Arash Najafi, Angela Boticella, Charles Roux, Lambros Tselikas, Alexandre Delpla, Marc Al Ahmar, Thierry de Baere, Frédéric Deschamps

Erschienen in: Supportive Care in Cancer | Ausgabe 1/2022

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Abstract

Objectives

Vertebral metastases with limited epidural extension (VMLEE) are frequently encountered in cancer patients; they can cause severe and debilitating symptoms including pain and neurological impairment and are usually treated by radiotherapy. In this study, we mainly evaluated the safety of combined local treatments (CLT), associating radiofrequency ablation (RFA) with vertebroplasty and radiotherapy (RT) to treat VMLEE. Also, we aimed to evaluate the short-term efficacy of CLT on bone metastases palliation and long-term prevention of skeletal-related events.

Methods

We retrospectively reviewed treatment complications, pain palliation, and skeletal complications after combined local treatments (CLT) for vertebral metastasis with limited epidural extension (VMLEE).

Results

Eighteen consecutive patients had CLT for 24 VMLEE, between June 2016 and January 2021. No major post-treatment complication was recorded. Nine patients had pain before the initiation of CLT. One month after CLT, only 3 patients had residual pain with a significant decrease of visual analogue scale (VAS), from 7.3 ± 2.4 to 2 ± 0 (p = .008), as well as the mean morphine milligram equivalent dose from 196.6 ± 135.7 to 38.5 ± 26, p = .008. Mean follow-up was 16.7 ± 11.5 months. Only one vertebra showed an increase of a preexisting vertebral fracture. Nine VMLEE had evidence of residual disease, including 2 which resulted in spinal cord compression (2, 11 months).

Conclusion

CLT was safe and effective for pain palliation and long-term prevention of skeletal-related events for treatment of patients with VMLEE. The effectiveness of this combined treatment on tumor control and epidural involvement on the long term needs further investigation.

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Titel: Combined local treatments for vertebral metastases with limited epidural extension
verfasst von: Khaled Madani
Arash Najafi
Angela Boticella
Charles Roux
Lambros Tselikas
Alexandre Delpla
Marc Al Ahmar
Thierry de Baere
Frédéric Deschamps
Publikationsdatum: 21.07.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 1/2022
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-021-06443-y

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Combined local treatments for vertebral metastases with limited epidural extension