Erschienen in:
01.11.2006 | Letter
Comment on: Nyirenda MJ, Dean S, Lyons V, Chapman KE, Seckl JR (2006) Prenatal programming of hepatocyte nuclear factor 4a in the rat: a key mechanism in the ‘foetal origins of hyperglycaemia’? Diabetologia 49: 1412–1420, and on: McCurdy CE, Friedman JE (2006) Early foetal programming of hepatic gluconeogenesis: glucocorticoids strike back. Diabetologia 49:1138–1141
verfasst von:
S. P. Burns, R. D. Cohen
Erschienen in:
Diabetologia
|
Ausgabe 11/2006
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Excerpt
Nyirenda et al. present compelling new evidence on the mechanism of fetal programming of gluconeogenesis by glucocorticoid administration during the last third of pregnancy in rats [
1], a study that is commented on by McCurdy and Friedman [
2]. Nyirenda et al. focus on a flux-generating enzyme of gluconeogenesis (phosphoenolpyruvate carboxykinase [PCK]) and the factors involved in its transcription, showing how
PCK mRNA and that of its controlling transcription factors are localised within the hepatic acinus. …