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Erschienen in: Psychiatric Quarterly 2/2008

01.06.2008 | Original Paper

Comorbid Anxiety in Bipolar Disorder Alters Treatment and Prognosis

verfasst von: Rif S. El-Mallakh, Michael Hollifield

Erschienen in: Psychiatric Quarterly | Ausgabe 2/2008

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Abstract

Mood disorders in general, and bipolar disorder in particular, are unique among the psychiatric conditions in that they are associated with extraordinarily high rates of comorbidity with a multitude of psychiatric and medical conditions. Among all the potential cormobidities, co-occurring anxiety disorders stand out due to their very high prevalence. Outcome in bipolar illness is worse in the presence of a comorbid anxiety disorder. The coexistence of an anxiety disorder presents a particularly difficult challenge in the treatment of bipolar illness since antidepressants, the mainstay of pharmacologic treatments for anxiety, may adversely alter the course of manic-depression. Identification of anxiety disorders in bipolar patients is important. The treatment plan needs to balance the potential benefit and harm of antidepressant administration.
Literatur
1.
Zurück zum Zitat Maremmani I, Perugi G, Pacini M, et al.: Toward a unitary perspective on the bipolar spectrum and substance abuse: opiate addiction as a paradigm. Journal of Affective Disorders 93(1–3):1–12, 2006PubMedCrossRef Maremmani I, Perugi G, Pacini M, et al.: Toward a unitary perspective on the bipolar spectrum and substance abuse: opiate addiction as a paradigm. Journal of Affective Disorders 93(1–3):1–12, 2006PubMedCrossRef
2.
Zurück zum Zitat McElroy SL, Kotwal R, Keck PE Jr, et al.: Comorbidity of bipolar and eating disorders: distinct or related disorders with shared dysregulations? Journal of Affective Disorders 86(2–3):107–127, 2005PubMedCrossRef McElroy SL, Kotwal R, Keck PE Jr, et al.: Comorbidity of bipolar and eating disorders: distinct or related disorders with shared dysregulations? Journal of Affective Disorders 86(2–3):107–127, 2005PubMedCrossRef
3.
Zurück zum Zitat American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders-Text Revision, ed 4, revised. Arlington, VA, American Psychiatric Association, 2000 American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders-Text Revision, ed 4, revised. Arlington, VA, American Psychiatric Association, 2000
4.
Zurück zum Zitat Merikangas KR, Akiskal HS, Angst J, et al.: Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Archives of General Psychiatry 64(5):543–552, 2007PubMedCrossRef Merikangas KR, Akiskal HS, Angst J, et al.: Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Archives of General Psychiatry 64(5):543–552, 2007PubMedCrossRef
5.
Zurück zum Zitat Angst J, Gamma A, Benazzi F, et al.: Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. Journal of Affective Disorders 73(1–2):133–146, 2003PubMedCrossRef Angst J, Gamma A, Benazzi F, et al.: Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. Journal of Affective Disorders 73(1–2):133–146, 2003PubMedCrossRef
6.
Zurück zum Zitat Tohen M, Strakowski SM, Zarate C Jr, et al.: The McLean–Harvard first-episode project: 6-month symptomatic and functional outcome in affective and nonaffective psychosis. Biological Psychiatry 48:467–476, 2000PubMedCrossRef Tohen M, Strakowski SM, Zarate C Jr, et al.: The McLean–Harvard first-episode project: 6-month symptomatic and functional outcome in affective and nonaffective psychosis. Biological Psychiatry 48:467–476, 2000PubMedCrossRef
7.
Zurück zum Zitat Tohen M, Zarate CA Jr, Hennen J, et al.: The McLean–Harvard first-episode mania study: Prediction of recovery and first recurrence. American Journal of Psychiatry 160:2099–2107, 2003PubMedCrossRef Tohen M, Zarate CA Jr, Hennen J, et al.: The McLean–Harvard first-episode mania study: Prediction of recovery and first recurrence. American Journal of Psychiatry 160:2099–2107, 2003PubMedCrossRef
8.
Zurück zum Zitat Murray CJL, Lopez AD (eds): The global burden of disease and injury series, volume 1: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Cambridge, MA, Harvard University Press, 1996 Murray CJL, Lopez AD (eds): The global burden of disease and injury series, volume 1: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Cambridge, MA, Harvard University Press, 1996
9.
Zurück zum Zitat Martinez-Aran A, Vieta E, Torrent C, et al.: Functional outcome in bipolar disorder: the role of clinical and cognitive factors. Bipolar Disorders 9(1–2):103–113, 2007PubMedCrossRef Martinez-Aran A, Vieta E, Torrent C, et al.: Functional outcome in bipolar disorder: the role of clinical and cognitive factors. Bipolar Disorders 9(1–2):103–113, 2007PubMedCrossRef
10.
Zurück zum Zitat Conus P, Cotton S, Abdel-Baki A, et al.: Symptomatic and functional outcome 12 months after a first episode of psychotic mania: barriers to recovery in a catchment area sample. Bipolar Disorders 8:221–231, 2006PubMedCrossRef Conus P, Cotton S, Abdel-Baki A, et al.: Symptomatic and functional outcome 12 months after a first episode of psychotic mania: barriers to recovery in a catchment area sample. Bipolar Disorders 8:221–231, 2006PubMedCrossRef
11.
Zurück zum Zitat DelBello MP, Hanseman D, Adler CM, et al.: Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode. American Journal of Psychiatry 164:582–590, 2007PubMedCrossRef DelBello MP, Hanseman D, Adler CM, et al.: Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode. American Journal of Psychiatry 164:582–590, 2007PubMedCrossRef
12.
Zurück zum Zitat Sareen J, Cox BJ, Afifi TO, et al.: Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adults. Archives of General Psychiatry 62:1249–1257, 2005PubMedCrossRef Sareen J, Cox BJ, Afifi TO, et al.: Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adults. Archives of General Psychiatry 62:1249–1257, 2005PubMedCrossRef
13.
Zurück zum Zitat Rodriguez BF, Bruce SE, Pagano ME, et al.: Relationships among psychosocial functioning, diagnostic comorbidity, and the recurrence of generalized anxiety disorder, panic disorder, and major depression. Journal of Anxiety Disorders 19:752–766, 2005PubMedCrossRef Rodriguez BF, Bruce SE, Pagano ME, et al.: Relationships among psychosocial functioning, diagnostic comorbidity, and the recurrence of generalized anxiety disorder, panic disorder, and major depression. Journal of Anxiety Disorders 19:752–766, 2005PubMedCrossRef
14.
Zurück zum Zitat Weissman MM, Klerman GL, Markowitz JS, et al.: Suicidal ideation and suicide attempts in panic disorder and attacks. New England Journal of Medicine 321(18):1209–1214, 1989PubMed Weissman MM, Klerman GL, Markowitz JS, et al.: Suicidal ideation and suicide attempts in panic disorder and attacks. New England Journal of Medicine 321(18):1209–1214, 1989PubMed
15.
Zurück zum Zitat Klerman GL, Weissman MM, Ouellette R, et al.: Panic attacks in the community. Social morbidity and health care utilization. JAMA 265(6):742–746, 1991PubMedCrossRef Klerman GL, Weissman MM, Ouellette R, et al.: Panic attacks in the community. Social morbidity and health care utilization. JAMA 265(6):742–746, 1991PubMedCrossRef
16.
Zurück zum Zitat Kessler RC, McGonagle KA, Zhao S, et al.: Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Archives of General Psychiatry 51:8–19, 1994PubMed Kessler RC, McGonagle KA, Zhao S, et al.: Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Archives of General Psychiatry 51:8–19, 1994PubMed
17.
Zurück zum Zitat Kessler RC, Rubinow DR, Holmes C et al.: The epidemiology of DSM-III-R bipolar I disorder in a general population survey. Psychological Medicine 27:1079–1089, 1997PubMedCrossRef Kessler RC, Rubinow DR, Holmes C et al.: The epidemiology of DSM-III-R bipolar I disorder in a general population survey. Psychological Medicine 27:1079–1089, 1997PubMedCrossRef
18.
Zurück zum Zitat Feske U, Frank E, Mallinger AG, et al.: Anxiety as a correlate of response to the acute treatment of bipolar I disorder. American Journal of Psychiatry 157:956–962, 2000PubMedCrossRef Feske U, Frank E, Mallinger AG, et al.: Anxiety as a correlate of response to the acute treatment of bipolar I disorder. American Journal of Psychiatry 157:956–962, 2000PubMedCrossRef
19.
Zurück zum Zitat Boylan KR, Bieling PJ, Marriott M et al.: Impact of comorbid anxiety disorders on outcome in a cohort of patients with bipolar disorder. Journal of Clinical Psychiatry 65:1106–1113, 2004PubMed Boylan KR, Bieling PJ, Marriott M et al.: Impact of comorbid anxiety disorders on outcome in a cohort of patients with bipolar disorder. Journal of Clinical Psychiatry 65:1106–1113, 2004PubMed
20.
Zurück zum Zitat Harpold TL, Wozniak J, Kwon A, et al.: Examining the association between pediatric bipolar disorder and anxiety disorders in psychiatrically referred children and adolescents. Journal of Affective Disorders 88:19–26, 2005PubMedCrossRef Harpold TL, Wozniak J, Kwon A, et al.: Examining the association between pediatric bipolar disorder and anxiety disorders in psychiatrically referred children and adolescents. Journal of Affective Disorders 88:19–26, 2005PubMedCrossRef
21.
Zurück zum Zitat Dickstein DP, Rich BA, Binstock AB, et al.: Comorbid anxiety in phenotypes of pediatric bipolar disorder. Journal of Child and Adolescent Psychopharmacology 15:534–548, 2005PubMedCrossRef Dickstein DP, Rich BA, Binstock AB, et al.: Comorbid anxiety in phenotypes of pediatric bipolar disorder. Journal of Child and Adolescent Psychopharmacology 15:534–548, 2005PubMedCrossRef
22.
Zurück zum Zitat Chen YW, Dilsaver SC: Comorbidity of panic disorder in bipolar illness: evidence from the epidemiologic catchment area survey. American Journal of Psychiatry 152:280–282, 1995PubMed Chen YW, Dilsaver SC: Comorbidity of panic disorder in bipolar illness: evidence from the epidemiologic catchment area survey. American Journal of Psychiatry 152:280–282, 1995PubMed
23.
Zurück zum Zitat Doughty CJ, Wells JE, Joyce PR, et al.: Bipolar-panic disorder comorbidity within bipolar disorder families: a study of siblings. Bipolar Disorders 6:245–252, 2004PubMedCrossRef Doughty CJ, Wells JE, Joyce PR, et al.: Bipolar-panic disorder comorbidity within bipolar disorder families: a study of siblings. Bipolar Disorders 6:245–252, 2004PubMedCrossRef
24.
Zurück zum Zitat MacKinnon DF, Xu J, McMahon FJ, et al.: Bipolar disorder and panic disorder in families: an analysis of chromosome 18 data. American Journal of Psychiatry 155:829–831, 1998PubMed MacKinnon DF, Xu J, McMahon FJ, et al.: Bipolar disorder and panic disorder in families: an analysis of chromosome 18 data. American Journal of Psychiatry 155:829–831, 1998PubMed
25.
Zurück zum Zitat Chen YW, Dilsaver SC: Comorbidity for obsessive-compulsive disorder in bipolar and unipolar disorders. Psychiatry Research 59:57–64, 1995PubMedCrossRef Chen YW, Dilsaver SC: Comorbidity for obsessive-compulsive disorder in bipolar and unipolar disorders. Psychiatry Research 59:57–64, 1995PubMedCrossRef
26.
Zurück zum Zitat Fogarty F, Russel JM, Newman SC, et al.: Epidemiology of psychiatric disorders in Edmonton: mania. Acta Psychiatrica Scandinavica 376(Suppl):16–23, 1994CrossRef Fogarty F, Russel JM, Newman SC, et al.: Epidemiology of psychiatric disorders in Edmonton: mania. Acta Psychiatrica Scandinavica 376(Suppl):16–23, 1994CrossRef
27.
Zurück zum Zitat Perugi G, Akiskal HS, Lattanzi L, et al.: The high prevalence of “soft” bipolar (II) features in atypical depression. Comprehensive Psychiatry 39:63–71, 1998PubMedCrossRef Perugi G, Akiskal HS, Lattanzi L, et al.: The high prevalence of “soft” bipolar (II) features in atypical depression. Comprehensive Psychiatry 39:63–71, 1998PubMedCrossRef
28.
Zurück zum Zitat Strakowski SM, Sax KW, McElroy SL, et al.: Course of psychiatric and substance abuse syndromes co-occurring with bipolar disorder after a first psychiatric hospitalization. Journal of Clinical Psychiatry 59:465–471, 1998PubMed Strakowski SM, Sax KW, McElroy SL, et al.: Course of psychiatric and substance abuse syndromes co-occurring with bipolar disorder after a first psychiatric hospitalization. Journal of Clinical Psychiatry 59:465–471, 1998PubMed
29.
Zurück zum Zitat Pini S, Dell’Osso L, Mastrocinque C, et al.: Axis I comorbidity in bipolar disorder with psychotic features. British Journal of Psychiatry 175:467–471, 1999PubMed Pini S, Dell’Osso L, Mastrocinque C, et al.: Axis I comorbidity in bipolar disorder with psychotic features. British Journal of Psychiatry 175:467–471, 1999PubMed
30.
Zurück zum Zitat Vieta E, Colom F, Corbella B, et al.: Clinical correlates of psychiatric comorbidity in bipolar I patients. Bipolar Disorders 3:253–258, 2001PubMedCrossRef Vieta E, Colom F, Corbella B, et al.: Clinical correlates of psychiatric comorbidity in bipolar I patients. Bipolar Disorders 3:253–258, 2001PubMedCrossRef
31.
Zurück zum Zitat Yerevanian BI, Koek RJ, Ramdev S: Anxiety disorders comorbidity in mood disorder subgroups: data from a mood disorders clinic. Journal of Affective Disorders 67:167–173, 2001PubMedCrossRef Yerevanian BI, Koek RJ, Ramdev S: Anxiety disorders comorbidity in mood disorder subgroups: data from a mood disorders clinic. Journal of Affective Disorders 67:167–173, 2001PubMedCrossRef
32.
Zurück zum Zitat Altindag A, Yanik M, Nebioglu M: The comorbidity of anxiety disorders in bipolar I patients: prevalence and clinical correlates. Israel Journal of Psychiatry and Related Sciences 43:10–15, 2006PubMed Altindag A, Yanik M, Nebioglu M: The comorbidity of anxiety disorders in bipolar I patients: prevalence and clinical correlates. Israel Journal of Psychiatry and Related Sciences 43:10–15, 2006PubMed
33.
Zurück zum Zitat Coryell W, Endicott J, Andreasen N, et al.: Bipolar I, bipolar II, and nonbipolar major depression among the relatives of affectively ill probands. American Journal of Psychiatry 142:817–821, 1985PubMed Coryell W, Endicott J, Andreasen N, et al.: Bipolar I, bipolar II, and nonbipolar major depression among the relatives of affectively ill probands. American Journal of Psychiatry 142:817–821, 1985PubMed
34.
Zurück zum Zitat Swartz CM, Shen WW: Is episodic obsessive compulsive disorder bipolar? A report of four cases. Journal of Affective Disorders 56:61–66, 1999PubMedCrossRef Swartz CM, Shen WW: Is episodic obsessive compulsive disorder bipolar? A report of four cases. Journal of Affective Disorders 56:61–66, 1999PubMedCrossRef
35.
Zurück zum Zitat Masi G, Perugi G, Toni C, et al.: Obsessive-compulsive bipolar comorbidity: focus on children and adolescents. Journal of Affective Disorders 78:175–183, 2004PubMedCrossRef Masi G, Perugi G, Toni C, et al.: Obsessive-compulsive bipolar comorbidity: focus on children and adolescents. Journal of Affective Disorders 78:175–183, 2004PubMedCrossRef
36.
Zurück zum Zitat Brown GR, McBride L, Bauer MS, et al.: Impact of childhood abuse on the course of bipolar disorder: a replication study in U.S. veterans. Journal of Affective Disorders 89:57–67, 2005CrossRef Brown GR, McBride L, Bauer MS, et al.: Impact of childhood abuse on the course of bipolar disorder: a replication study in U.S. veterans. Journal of Affective Disorders 89:57–67, 2005CrossRef
37.
Zurück zum Zitat Goldberg JF, Garno JL: Development of posttraumatic stress disorder in adult bipolar patients with histories of severe childhood abuse. Journal of Psychiatric Research 39:595–601, 2005PubMedCrossRef Goldberg JF, Garno JL: Development of posttraumatic stress disorder in adult bipolar patients with histories of severe childhood abuse. Journal of Psychiatric Research 39:595–601, 2005PubMedCrossRef
38.
Zurück zum Zitat Kennedy BL, Dhaliwal N, Pedley L, et al.: Post-traumatic stress disorder in subjects with schizophrenia and bipolar disorder. Journal of the Kentucky Medical Association 100:395–399, 2002PubMed Kennedy BL, Dhaliwal N, Pedley L, et al.: Post-traumatic stress disorder in subjects with schizophrenia and bipolar disorder. Journal of the Kentucky Medical Association 100:395–399, 2002PubMed
39.
Zurück zum Zitat Pollack MH, Simon NM, Fagiolini A, et al.: Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder. Journal of Clinical Psychiatry 67:394–357, 2006PubMed Pollack MH, Simon NM, Fagiolini A, et al.: Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder. Journal of Clinical Psychiatry 67:394–357, 2006PubMed
40.
Zurück zum Zitat Otto MW, Perlman CA, Wernicke R, et al.: Posttraumatic stress disorder in patients with bipolar disorder: a review of prevalence, correlates, and treatment strategies. Bipolar Disorders 6:470–479, 2004PubMedCrossRef Otto MW, Perlman CA, Wernicke R, et al.: Posttraumatic stress disorder in patients with bipolar disorder: a review of prevalence, correlates, and treatment strategies. Bipolar Disorders 6:470–479, 2004PubMedCrossRef
41.
Zurück zum Zitat Baldassano CF, Marangell LB, Gyulai L, et al.: Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participants. Bipolar Disorders 7:465–470, 2005PubMedCrossRef Baldassano CF, Marangell LB, Gyulai L, et al.: Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participants. Bipolar Disorders 7:465–470, 2005PubMedCrossRef
42.
Zurück zum Zitat Henin A, Biederman J, Mick E, et al.: Psychopathology in the offspring of parents with bipolar disorder: a controlled study. Biological Psychiatry 58:554–561, 2005PubMedCrossRef Henin A, Biederman J, Mick E, et al.: Psychopathology in the offspring of parents with bipolar disorder: a controlled study. Biological Psychiatry 58:554–561, 2005PubMedCrossRef
43.
Zurück zum Zitat Grant BF, Hasin DS, Blanco C et al.: The epidemiology of social anxiety disorder in the United States: results from the National Epidemiologic survey on Alcohol and Related Conditions. Journal of Clinical Psychiatry 66:1351–1361, 2005PubMed Grant BF, Hasin DS, Blanco C et al.: The epidemiology of social anxiety disorder in the United States: results from the National Epidemiologic survey on Alcohol and Related Conditions. Journal of Clinical Psychiatry 66:1351–1361, 2005PubMed
44.
Zurück zum Zitat Gaudiano BA, Miller IW: Anxiety disorder comorbidity in bipolar I disorder: relationship to depression severity and treatment outcome. Depression and Anxiety 21:71–77, 2005PubMedCrossRef Gaudiano BA, Miller IW: Anxiety disorder comorbidity in bipolar I disorder: relationship to depression severity and treatment outcome. Depression and Anxiety 21:71–77, 2005PubMedCrossRef
45.
Zurück zum Zitat Keller MB: Prevalence and impact of comorbid anxiety and bipolar disorder. Journal of Clinical Psychiatry 67(Suppl 1):5–7, 2006PubMed Keller MB: Prevalence and impact of comorbid anxiety and bipolar disorder. Journal of Clinical Psychiatry 67(Suppl 1):5–7, 2006PubMed
46.
Zurück zum Zitat Allen MH, Chessick CA, Miklowitz DJ, et al.: Contributors to suicidal ideation among bipolar patients with and without a history of suicide attempts. Suicide and Life Threatening Behavior 35:671–680, 2005PubMedCrossRef Allen MH, Chessick CA, Miklowitz DJ, et al.: Contributors to suicidal ideation among bipolar patients with and without a history of suicide attempts. Suicide and Life Threatening Behavior 35:671–680, 2005PubMedCrossRef
47.
Zurück zum Zitat Young LT, Cooke RG, Robb JC, et al.: Anxious and non-anxious bipolar disorder. Journal of Affective Disorders 29:49–52, 1993PubMedCrossRef Young LT, Cooke RG, Robb JC, et al.: Anxious and non-anxious bipolar disorder. Journal of Affective Disorders 29:49–52, 1993PubMedCrossRef
48.
Zurück zum Zitat Perlis RH, Miyahara S, Marangell LB, et al.: Long-Term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biological Psychiatry 55(9):875–881, 2004PubMedCrossRef Perlis RH, Miyahara S, Marangell LB, et al.: Long-Term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biological Psychiatry 55(9):875–881, 2004PubMedCrossRef
49.
Zurück zum Zitat Otto MW, Simon NM, Wisniewski SR et al.: Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders. British Journal of Psychiatry 189:20–25, 2006PubMedCrossRef Otto MW, Simon NM, Wisniewski SR et al.: Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders. British Journal of Psychiatry 189:20–25, 2006PubMedCrossRef
50.
Zurück zum Zitat Simon NM, Zalta AK, Otto MW, et al.: The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar diosorder. Journal Psychiatric Research 41:255–264, 2007CrossRef Simon NM, Zalta AK, Otto MW, et al.: The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar diosorder. Journal Psychiatric Research 41:255–264, 2007CrossRef
51.
Zurück zum Zitat Simon NM, Otto MW, Wisniewski SR, et al.: Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). American Journal of Psychiatry 161:2222–2229, 2004PubMedCrossRef Simon NM, Otto MW, Wisniewski SR, et al.: Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). American Journal of Psychiatry 161:2222–2229, 2004PubMedCrossRef
52.
Zurück zum Zitat Matza LS, Rajagopalan KS, Thompson CL, et al.: Misdiagnosed patients with bipolar disorder: comorbidities, treatment patterns, and direct treatment costs. Journal of Clinical Psychiatry 66:1432–1440, 2005PubMed Matza LS, Rajagopalan KS, Thompson CL, et al.: Misdiagnosed patients with bipolar disorder: comorbidities, treatment patterns, and direct treatment costs. Journal of Clinical Psychiatry 66:1432–1440, 2005PubMed
53.
Zurück zum Zitat Hollifield M, Mackey A, Davidson J: Integrating therapies for anxiety disorders. Psychiatric Annals 36:329–338, 2006 Hollifield M, Mackey A, Davidson J: Integrating therapies for anxiety disorders. Psychiatric Annals 36:329–338, 2006
54.
Zurück zum Zitat van der Kolk BA, Spinazzola J, Blaustein ME, et al.: A randomized clinical trial of eye movement desensitization and reprocessing (EMDR), fluoxetine, and pill placebo in the treatment of posttraumatic stress disorder: treatment effects and long-term maintenance. Journal of Clinical Psychiatry 68:37–46, 2007PubMedCrossRef van der Kolk BA, Spinazzola J, Blaustein ME, et al.: A randomized clinical trial of eye movement desensitization and reprocessing (EMDR), fluoxetine, and pill placebo in the treatment of posttraumatic stress disorder: treatment effects and long-term maintenance. Journal of Clinical Psychiatry 68:37–46, 2007PubMedCrossRef
55.
Zurück zum Zitat Asnis GM, Kohn SR, Henderson M, et al.: SSRIs versus non-SSRIs in post-traumatic stress disorder: an update with recommendations. Drugs 64:383–404, 2004PubMedCrossRef Asnis GM, Kohn SR, Henderson M, et al.: SSRIs versus non-SSRIs in post-traumatic stress disorder: an update with recommendations. Drugs 64:383–404, 2004PubMedCrossRef
56.
Zurück zum Zitat Marshall RD, Beebe KL, Oldham M, et al.: Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled study. American Journal of Psychiatry 158(12):1982–1988, 2001PubMedCrossRef Marshall RD, Beebe KL, Oldham M, et al.: Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled study. American Journal of Psychiatry 158(12):1982–1988, 2001PubMedCrossRef
57.
Zurück zum Zitat Tucker P, Zaninelli R, Yehuda R, et al.: Paroxetine in the treatment of chronic posttraumatic stress disorder: results of a placebo-controlled, flexible-dosage trial. Journal of Clinical Psychiatry 62(11):860–868, 2001PubMed Tucker P, Zaninelli R, Yehuda R, et al.: Paroxetine in the treatment of chronic posttraumatic stress disorder: results of a placebo-controlled, flexible-dosage trial. Journal of Clinical Psychiatry 62(11):860–868, 2001PubMed
58.
Zurück zum Zitat Pollack MH, Lepola U, Kpenen H, et al.: A double-blind study of the efficacy of venlafaxine extended-release, paroxetine, and placebo in the treatment of panic disorder. Depression and Anxiety 24(1):1–14, 2007PubMedCrossRef Pollack MH, Lepola U, Kpenen H, et al.: A double-blind study of the efficacy of venlafaxine extended-release, paroxetine, and placebo in the treatment of panic disorder. Depression and Anxiety 24(1):1–14, 2007PubMedCrossRef
59.
Zurück zum Zitat Pollack MH, Mangano R, Entsuah R, et al.: A randomized controlled trial of venlafaxine ER and paroxetine in the treatment of outpatients with panic disorder. Psychopharmacology (Berlin) 2007 (Epub ahead of print) Pollack MH, Mangano R, Entsuah R, et al.: A randomized controlled trial of venlafaxine ER and paroxetine in the treatment of outpatients with panic disorder. Psychopharmacology (Berlin) 2007 (Epub ahead of print)
60.
Zurück zum Zitat Shuurmans J, Comijs H, Emmelkamp PM, et al.: A randomized, controlled trial of the effectiveness of cognitive-behavioral therapy and sertraline versus a waitlist control group for anxiety disorders in older adults. American Journal of Geriatric Psychiatry 14:255–263, 2006CrossRef Shuurmans J, Comijs H, Emmelkamp PM, et al.: A randomized, controlled trial of the effectiveness of cognitive-behavioral therapy and sertraline versus a waitlist control group for anxiety disorders in older adults. American Journal of Geriatric Psychiatry 14:255–263, 2006CrossRef
61.
Zurück zum Zitat Kamijima K, Kuboki T, Kumano H, et al.: A placebo-controlled, randomized withdrawal study of sertraline for panic disorder in Japan. International Clinical Psychopharmacology 20(5):265–273, 2005PubMedCrossRef Kamijima K, Kuboki T, Kumano H, et al.: A placebo-controlled, randomized withdrawal study of sertraline for panic disorder in Japan. International Clinical Psychopharmacology 20(5):265–273, 2005PubMedCrossRef
62.
Zurück zum Zitat Stahl SM, Gergel I, Li D: Escitalopram in the treatment of panic disorder: a randomized, double-blind, placebo-controlled trial. Journal of Clinical Psychiatry 64:1322–1327, 2003PubMedCrossRef Stahl SM, Gergel I, Li D: Escitalopram in the treatment of panic disorder: a randomized, double-blind, placebo-controlled trial. Journal of Clinical Psychiatry 64:1322–1327, 2003PubMedCrossRef
63.
Zurück zum Zitat Londborg PD, Wolkow R, Smith WT et al.: Sertraline in the treatment of panic disorder. A multi-site, double-blind, placebo-controlled, fixed-dose investigation. British Journal of Psychiatry 173:54–60, 1998PubMed Londborg PD, Wolkow R, Smith WT et al.: Sertraline in the treatment of panic disorder. A multi-site, double-blind, placebo-controlled, fixed-dose investigation. British Journal of Psychiatry 173:54–60, 1998PubMed
64.
Zurück zum Zitat Oehrberg S, Christiansen PE, Behnke K, et al.: Paroxetine in the treatment of panic disorder: a randomized, double-blind, placebo-controlled study. British Journal of Psychiatry 167:374–379, 1995PubMedCrossRef Oehrberg S, Christiansen PE, Behnke K, et al.: Paroxetine in the treatment of panic disorder: a randomized, double-blind, placebo-controlled study. British Journal of Psychiatry 167:374–379, 1995PubMedCrossRef
65.
Zurück zum Zitat Brawman-Mintzer O, Knapp RG, et al.: Sertraline treatment for generalized anxiety disorder: a randomized, double-blind, placebo-controlled study. Journal of Clinical Psychiatry 67(6):874–881, 2006PubMed Brawman-Mintzer O, Knapp RG, et al.: Sertraline treatment for generalized anxiety disorder: a randomized, double-blind, placebo-controlled study. Journal of Clinical Psychiatry 67(6):874–881, 2006PubMed
66.
Zurück zum Zitat Goodman WK, Bose A, Wang Q: Treatment of generalized anxiety disorder with escitalopram: pooled results from double-blind, placebo-controlled trials. Journal of Affective Disorders 87(2–3):161–167, 2005PubMedCrossRef Goodman WK, Bose A, Wang Q: Treatment of generalized anxiety disorder with escitalopram: pooled results from double-blind, placebo-controlled trials. Journal of Affective Disorders 87(2–3):161–167, 2005PubMedCrossRef
67.
Zurück zum Zitat Davidson JR, Bose A, Korotzer A, et al.: Escitalopram in the treatment of generalized anxiety disorder: double-blind, placebo controlled, flexible-dose study. Depression and Anxiety 19:234–240, 2004PubMedCrossRef Davidson JR, Bose A, Korotzer A, et al.: Escitalopram in the treatment of generalized anxiety disorder: double-blind, placebo controlled, flexible-dose study. Depression and Anxiety 19:234–240, 2004PubMedCrossRef
68.
Zurück zum Zitat Hedges DW, Brown BL, Shwalb DA, et al.: The efficacy of selective serotonin reuptake inhibitors in adult social anxiety disorder: a meta-analysis of double-blind, placebo-controlled trials. Journal of Psychopharmacology 21(1):102–111, 2007PubMedCrossRef Hedges DW, Brown BL, Shwalb DA, et al.: The efficacy of selective serotonin reuptake inhibitors in adult social anxiety disorder: a meta-analysis of double-blind, placebo-controlled trials. Journal of Psychopharmacology 21(1):102–111, 2007PubMedCrossRef
69.
Zurück zum Zitat Stein DJ, Andersen EW, Tonnoir B, et al.: Escitalopram in obsessive-compulsive disorder: a randomized, placebo-controlled, paroxetine-referenced, fixed-dose, 24-week study. Current Medical Research and Opinion 23:701–711, 2007PubMedCrossRef Stein DJ, Andersen EW, Tonnoir B, et al.: Escitalopram in obsessive-compulsive disorder: a randomized, placebo-controlled, paroxetine-referenced, fixed-dose, 24-week study. Current Medical Research and Opinion 23:701–711, 2007PubMedCrossRef
70.
Zurück zum Zitat Pallanti S, Quercioli L, Koran LM: Citalopram intravenous infusion in resistant obsessive-compulsive disorder: an open trial. Journal of Clinical Psychiatry 63:796–801, 2002PubMed Pallanti S, Quercioli L, Koran LM: Citalopram intravenous infusion in resistant obsessive-compulsive disorder: an open trial. Journal of Clinical Psychiatry 63:796–801, 2002PubMed
71.
Zurück zum Zitat Montgomery SA, Kasper S, Stein DJ, et al.: Citalopram 20 mg, 40 mg, and 60 mg are all effective and well tolerated compared with placebo in obsessive-compulsive disorder. International Clinical Psychopharmacology 16:75–86, 2001PubMedCrossRef Montgomery SA, Kasper S, Stein DJ, et al.: Citalopram 20 mg, 40 mg, and 60 mg are all effective and well tolerated compared with placebo in obsessive-compulsive disorder. International Clinical Psychopharmacology 16:75–86, 2001PubMedCrossRef
72.
Zurück zum Zitat Becker ME, Hertzberg MA, Moore SD, et al.: A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder. Journal of Clinical Psychopharmacology 27:193–197, 2007PubMedCrossRef Becker ME, Hertzberg MA, Moore SD, et al.: A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder. Journal of Clinical Psychopharmacology 27:193–197, 2007PubMedCrossRef
73.
Zurück zum Zitat El-Mallakh RS, Karippot A: Use of antidepressants to treat depression in bipolar disorder. Psychiatric Services 53:580–584, 2002PubMedCrossRef El-Mallakh RS, Karippot A: Use of antidepressants to treat depression in bipolar disorder. Psychiatric Services 53:580–584, 2002PubMedCrossRef
74.
Zurück zum Zitat Ghaemi SN, Hsu DJ, Soldani F, et al.: Antidepressants in bipolar disorder: the case for caution. Bipolar Disorders 5(6):421–433, 2003PubMedCrossRef Ghaemi SN, Hsu DJ, Soldani F, et al.: Antidepressants in bipolar disorder: the case for caution. Bipolar Disorders 5(6):421–433, 2003PubMedCrossRef
75.
Zurück zum Zitat El-Mallakh RS, Karippot A: Chronic depression in bipolar disorder. American Journal of Psychiatry 163:1337–1341 (quiz on 1478), 2006 El-Mallakh RS, Karippot A: Chronic depression in bipolar disorder. American Journal of Psychiatry 163:1337–1341 (quiz on 1478), 2006
76.
Zurück zum Zitat El-Mallakh RS, Karippot A: Antidepressant-associated chronic irritable dysphoria (ACID) in bipolar disorder. Journal of Affect Disorders 84:267–272, 2005CrossRef El-Mallakh RS, Karippot A: Antidepressant-associated chronic irritable dysphoria (ACID) in bipolar disorder. Journal of Affect Disorders 84:267–272, 2005CrossRef
77.
Zurück zum Zitat Kukopulos A, Caliari B, Tundo A, et al.: Rapid Cyclers, temperament, and antidepressants. Comprehensive Psychiatry 24:249–258, 1983PubMedCrossRef Kukopulos A, Caliari B, Tundo A, et al.: Rapid Cyclers, temperament, and antidepressants. Comprehensive Psychiatry 24:249–258, 1983PubMedCrossRef
78.
Zurück zum Zitat Altshuler LL, Post RM, Leverich GS, et al.: Antidepressant-induced mania and cycle acceleration: a controversy revisited. American Journal of Psychiatry 152:1130–1138, 1995PubMed Altshuler LL, Post RM, Leverich GS, et al.: Antidepressant-induced mania and cycle acceleration: a controversy revisited. American Journal of Psychiatry 152:1130–1138, 1995PubMed
79.
Zurück zum Zitat Simon NM, Otto MW, Weiss RD, et al.: Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD. Journal of Clinical Psychopharmacollogy 24:512–520, 2004CrossRef Simon NM, Otto MW, Weiss RD, et al.: Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD. Journal of Clinical Psychopharmacollogy 24:512–520, 2004CrossRef
80.
Zurück zum Zitat Lembke A, Miklowitz DJ, Otto MW, et al.: Psychosocial service utilization by patients with bipolar disorders: data from the first 500 participants in the Systematic Treatment Enhancement Program. Journal of Psychiatric Practice 10:81–87, 2004PubMedCrossRef Lembke A, Miklowitz DJ, Otto MW, et al.: Psychosocial service utilization by patients with bipolar disorders: data from the first 500 participants in the Systematic Treatment Enhancement Program. Journal of Psychiatric Practice 10:81–87, 2004PubMedCrossRef
81.
Zurück zum Zitat Pande AC, Davidson JR, Jefferson JW, et al.: Treatment of social phobia with gabapentin: a placebo-controlled study. Journal of Clinical Psychopharmacology 19(4):341–348, 1999PubMedCrossRef Pande AC, Davidson JR, Jefferson JW, et al.: Treatment of social phobia with gabapentin: a placebo-controlled study. Journal of Clinical Psychopharmacology 19(4):341–348, 1999PubMedCrossRef
82.
Zurück zum Zitat Pande AC, Pollack MH, Crockatt J et al.: Placebo-controlled study of gabapentin treatment of panic disorder. Journal of Clinical Psychopharmacology 20(4):467–471, 2000PubMedCrossRef Pande AC, Pollack MH, Crockatt J et al.: Placebo-controlled study of gabapentin treatment of panic disorder. Journal of Clinical Psychopharmacology 20(4):467–471, 2000PubMedCrossRef
83.
Zurück zum Zitat Sepede G, De Berardis D, Gambi F, et al.: Olanzapine augmentation in treatment-resistant panic disorder: a 12-week, fixed-dose, open-label trial. Journal of Clinical Psychopharmacology 26:45–49, 2006PubMedCrossRef Sepede G, De Berardis D, Gambi F, et al.: Olanzapine augmentation in treatment-resistant panic disorder: a 12-week, fixed-dose, open-label trial. Journal of Clinical Psychopharmacology 26:45–49, 2006PubMedCrossRef
84.
Zurück zum Zitat Hollifield M, Thompson PM, Ruiz JE, et al.: Potential effectiveness and safety of olanzapine in refractory panic disorder. Depression and Anxiety 21:33–40, 2005PubMedCrossRef Hollifield M, Thompson PM, Ruiz JE, et al.: Potential effectiveness and safety of olanzapine in refractory panic disorder. Depression and Anxiety 21:33–40, 2005PubMedCrossRef
85.
Zurück zum Zitat Hirshfeld RM, Weisler RH, Raines SR, et al.: Quetiapine in the treatment of anxiety in patients with bipolar I or II depression: a secondary analysis from a randomized, double-blind, placebo-controlled study. Journal of Clinical Psychiatry 67:355–363, 2006 Hirshfeld RM, Weisler RH, Raines SR, et al.: Quetiapine in the treatment of anxiety in patients with bipolar I or II depression: a secondary analysis from a randomized, double-blind, placebo-controlled study. Journal of Clinical Psychiatry 67:355–363, 2006
86.
Zurück zum Zitat Bystritsky A, Ackerman DL, Rosen RM, et al.: Augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder using adjunctive olanzapine: a placebo-controlled trial. Journal of Clinical Psychiatry 65:565–568, 2004PubMed Bystritsky A, Ackerman DL, Rosen RM, et al.: Augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder using adjunctive olanzapine: a placebo-controlled trial. Journal of Clinical Psychiatry 65:565–568, 2004PubMed
87.
Zurück zum Zitat Oruc L, Cavuljuga S: Olanzapine in treatment of patients with bipolar I disorder and panic comorbidity: a case study. Bosnian Journal of Basic Medical Science 3:67–69, 2003 Oruc L, Cavuljuga S: Olanzapine in treatment of patients with bipolar I disorder and panic comorbidity: a case study. Bosnian Journal of Basic Medical Science 3:67–69, 2003
88.
Zurück zum Zitat Hamner MB, Robert S, Frueh C: Treatment-resistant posttraumatic stress disorder: strategies for intervention. CNS Spectrums 9:740–752, 2004PubMed Hamner MB, Robert S, Frueh C: Treatment-resistant posttraumatic stress disorder: strategies for intervention. CNS Spectrums 9:740–752, 2004PubMed
89.
Zurück zum Zitat Keck PE Jr, McElroy SL, Friedman LM: Valproate and carbamazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states, and behavioral dyscontrol syndromes. Journal of Clinical Psychopharmacology 12(1 Suppl):36S–41S, 1992PubMed Keck PE Jr, McElroy SL, Friedman LM: Valproate and carbamazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states, and behavioral dyscontrol syndromes. Journal of Clinical Psychopharmacology 12(1 Suppl):36S–41S, 1992PubMed
90.
Zurück zum Zitat Munjack DJ, Croker B, Cabe D et al.: Alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks. Journal of Clinical Psychopharmacology 9:22–27, 1989PubMedCrossRef Munjack DJ, Croker B, Cabe D et al.: Alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks. Journal of Clinical Psychopharmacology 9:22–27, 1989PubMedCrossRef
91.
Zurück zum Zitat Swinson RP, Pecknold JC, Kuch K: Psychopharmacological treatment of panic disorder and related states: a placebo controlled study of alprazolam. Progress in Neuropsychopharmacology and Biological Psychiatry 11:105–113, 1987CrossRef Swinson RP, Pecknold JC, Kuch K: Psychopharmacological treatment of panic disorder and related states: a placebo controlled study of alprazolam. Progress in Neuropsychopharmacology and Biological Psychiatry 11:105–113, 1987CrossRef
92.
Zurück zum Zitat Chouinard G: The use of benzodiazepines in the treatment of manic-depressive illness. Journal of Clinical Psychiatry 49(Suppl):15–20, 1988PubMed Chouinard G: The use of benzodiazepines in the treatment of manic-depressive illness. Journal of Clinical Psychiatry 49(Suppl):15–20, 1988PubMed
93.
Zurück zum Zitat Valença AM, Nardi AE, Nascimento I, Mezzasalma MA, Lopes FL, Zin W: Double-blind clonazepam vs placebo in panic disorder treatment. Arquivos de Neuro-Psiquiatria 58(4):1025–1029, 2000PubMed Valença AM, Nardi AE, Nascimento I, Mezzasalma MA, Lopes FL, Zin W: Double-blind clonazepam vs placebo in panic disorder treatment. Arquivos de Neuro-Psiquiatria 58(4):1025–1029, 2000PubMed
94.
Zurück zum Zitat Seedat S, Stein MB: Double-blind, placebo-controlled assessment of combined clonazepam with paroxetine compared with paroxetine monotherapy for generalized social anxiety disorder. Journal of Clinical Psychiatry 65(2):244–248, 2004PubMed Seedat S, Stein MB: Double-blind, placebo-controlled assessment of combined clonazepam with paroxetine compared with paroxetine monotherapy for generalized social anxiety disorder. Journal of Clinical Psychiatry 65(2):244–248, 2004PubMed
95.
Zurück zum Zitat Clark RE, Xie H, Brunette MF: Benzodiazepine prescription practices and substance abuse in persons with severe mental illness. Journal of Clinical Psychiatry 65:151–155, 2004PubMedCrossRef Clark RE, Xie H, Brunette MF: Benzodiazepine prescription practices and substance abuse in persons with severe mental illness. Journal of Clinical Psychiatry 65:151–155, 2004PubMedCrossRef
96.
Zurück zum Zitat Brunette MF, Noordsy DL, Xie H, et al.: Benzodiazepine use and abuse among patients with severe mental illness and co-occurring substance use disorders. Psychiatric Services 54:1395–1401, 2003PubMedCrossRef Brunette MF, Noordsy DL, Xie H, et al.: Benzodiazepine use and abuse among patients with severe mental illness and co-occurring substance use disorders. Psychiatric Services 54:1395–1401, 2003PubMedCrossRef
97.
Zurück zum Zitat Weiss RD, Greenfield SF, Najavits LM, et al.: Medication compliance among patients with bipolar disorder and substance use disorder. Journal of Clinical Psychiatry 59:172–174, 1998PubMed Weiss RD, Greenfield SF, Najavits LM, et al.: Medication compliance among patients with bipolar disorder and substance use disorder. Journal of Clinical Psychiatry 59:172–174, 1998PubMed
98.
Zurück zum Zitat Turkington D, Gill P: Mania induced by lorazepam withdrawal: a report of two cases. Journal of Affective Disorders 17(1):93–95, 1989PubMedCrossRef Turkington D, Gill P: Mania induced by lorazepam withdrawal: a report of two cases. Journal of Affective Disorders 17(1):93–95, 1989PubMedCrossRef
99.
Zurück zum Zitat Miller NS, Guttman JC: The integration of pharmacological therapy for comorbid psychiatric and addictive disorders. Journal of Psychoactive Drugs 29:249–254, 1997PubMed Miller NS, Guttman JC: The integration of pharmacological therapy for comorbid psychiatric and addictive disorders. Journal of Psychoactive Drugs 29:249–254, 1997PubMed
100.
Zurück zum Zitat Wilhelm FH, Roth WT: Acute and delayed effects of alprazolam on flight phobics during exposure. Behavior Research and Therapy 35:831–841, 1997CrossRef Wilhelm FH, Roth WT: Acute and delayed effects of alprazolam on flight phobics during exposure. Behavior Research and Therapy 35:831–841, 1997CrossRef
101.
Zurück zum Zitat Gelpin E, Bonne O, Peri T, et al.: Treatment of recent trauma survivors with benzodiazepines: a prospective study. Journal of Clinical Psychiatry 57:390–394, 1996PubMed Gelpin E, Bonne O, Peri T, et al.: Treatment of recent trauma survivors with benzodiazepines: a prospective study. Journal of Clinical Psychiatry 57:390–394, 1996PubMed
102.
Zurück zum Zitat Chouinard G, Labonte A, Fontaine R, et al.: New concepts in benzodiazepine therapy: rebound anxiety and new indications for the more potent benzodiazepines. Progress in Neuropsychopharmacology and Biological Psychiatry 7:669–673, 1983CrossRef Chouinard G, Labonte A, Fontaine R, et al.: New concepts in benzodiazepine therapy: rebound anxiety and new indications for the more potent benzodiazepines. Progress in Neuropsychopharmacology and Biological Psychiatry 7:669–673, 1983CrossRef
103.
Zurück zum Zitat Dusseldorp E, Spinhoven P, Bakker A, et al.: Which panic disorder patients benefit from which treatment: cognitive therapy or antidepressants? Psychotherapy and Psychosomatics 76(3):154–61, 2007PubMedCrossRef Dusseldorp E, Spinhoven P, Bakker A, et al.: Which panic disorder patients benefit from which treatment: cognitive therapy or antidepressants? Psychotherapy and Psychosomatics 76(3):154–61, 2007PubMedCrossRef
104.
Zurück zum Zitat Anderson RA, Rees CS: Group versus individual cognitive-behavioral treatment for obsessive-compulsive disorder: a controlled trial. Behavior Research and Therapy 45(1):123–37, 2007CrossRef Anderson RA, Rees CS: Group versus individual cognitive-behavioral treatment for obsessive-compulsive disorder: a controlled trial. Behavior Research and Therapy 45(1):123–37, 2007CrossRef
105.
Zurück zum Zitat Linden M, Zubraegel D, Baer T, et al.: Efficacy of cognitive behaviour therapy in generalized anxiety disorders. Results of a controlled clinical trial (Berlin CBT-GAD Study). Psychotherapy and Psychosomatics 74:36–42, 2005PubMedCrossRef Linden M, Zubraegel D, Baer T, et al.: Efficacy of cognitive behaviour therapy in generalized anxiety disorders. Results of a controlled clinical trial (Berlin CBT-GAD Study). Psychotherapy and Psychosomatics 74:36–42, 2005PubMedCrossRef
106.
Zurück zum Zitat Blanchard EB, Hickling EJ, Devineni T, et al.: A controlled evaluation of cognitive behavioural therapy for posttraumatic stress in motor vehicle accident survivors. Behavior Research and Therapy 41(1):79–96, 2003CrossRef Blanchard EB, Hickling EJ, Devineni T, et al.: A controlled evaluation of cognitive behavioural therapy for posttraumatic stress in motor vehicle accident survivors. Behavior Research and Therapy 41(1):79–96, 2003CrossRef
107.
Zurück zum Zitat Mitte K: A meta-analysis of psycho- and pharmacotherapy in panic disorder with and without agoraphobia. Journal of Affective Disorders 88:27–45, 2005PubMedCrossRef Mitte K: A meta-analysis of psycho- and pharmacotherapy in panic disorder with and without agoraphobia. Journal of Affective Disorders 88:27–45, 2005PubMedCrossRef
108.
Zurück zum Zitat Hollon SD, Stewart MO, Strunk D: Enduring effects for cognitive behavior therapy in the treatment of depression and anxiety. Annual Review of Psychology 57:285–315, 2006PubMedCrossRef Hollon SD, Stewart MO, Strunk D: Enduring effects for cognitive behavior therapy in the treatment of depression and anxiety. Annual Review of Psychology 57:285–315, 2006PubMedCrossRef
109.
Zurück zum Zitat Fava GA, Ruini C, Rafanelli C: Sequential treatment of mood and anxiety disorders. Journal of Clinical Psychiatry 66:1392–1400, 2005PubMed Fava GA, Ruini C, Rafanelli C: Sequential treatment of mood and anxiety disorders. Journal of Clinical Psychiatry 66:1392–1400, 2005PubMed
110.
Zurück zum Zitat Scott J, Paykel E, Morriss R, et al.: Cognitive behavioral therapy for severe and recurrent bipolar disorders: a randomized controlled trial. British Journal of Psychiatry 188:313–320, 2006PubMedCrossRef Scott J, Paykel E, Morriss R, et al.: Cognitive behavioral therapy for severe and recurrent bipolar disorders: a randomized controlled trial. British Journal of Psychiatry 188:313–320, 2006PubMedCrossRef
111.
Zurück zum Zitat Bell JR, Mitchell PB, Corry JC, et al.: A randomized controlled trial of cognition therapy for bipolar disorder: focus on long-term change. Journal of Clinical Psychiatry 67:277–286, 2006CrossRef Bell JR, Mitchell PB, Corry JC, et al.: A randomized controlled trial of cognition therapy for bipolar disorder: focus on long-term change. Journal of Clinical Psychiatry 67:277–286, 2006CrossRef
Metadaten
Titel
Comorbid Anxiety in Bipolar Disorder Alters Treatment and Prognosis
verfasst von
Rif S. El-Mallakh
Michael Hollifield
Publikationsdatum
01.06.2008
Verlag
Springer US
Erschienen in
Psychiatric Quarterly / Ausgabe 2/2008
Print ISSN: 0033-2720
Elektronische ISSN: 1573-6709
DOI
https://doi.org/10.1007/s11126-008-9071-5

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