The online version of this article (doi:10.1186/1476-7120-10-33) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
TY, OCR and IKJ carried out subject recruitment and analyzed data. MK analyzed data and wrote the manuscript. YI, MO, and TK performed integrated backscatter ultrasound analysis. HF revised manuscript. AH, KN, GT and SM analyzed data. All authors read and approved the final manuscript.
We have no financial or other relations that could lead to conflict of interest.
The purpose of this study was to determine the cut-off values of Hounsfield units (HU) for the discrimination of plaque components and to evaluate the feasibility of measurement of the volume of plaque components using multi-detector row computed tomography (MDCT).
Coronary lesions (125 lesions in 125 patients) were visualized by both integrated backscatter intravascular ultrasound (IB-IVUS) and 64-slice MDCT at the same site. The IB values were used as a gold standard to determine the cut off values of HU for the discrimination of plaque components.
Plaques were classified as lipid pool (n =50), fibrosis (n =65) or calcification (n =35) by IB-IVUS. The HU of lipid pool, fibrosis and calcification were 18 ± 18 HU (−19 to 58 HU), 95 ± 24 HU (46 to 154 HU) and 378 ± 99 HU (188 to 605 HU), respectively. Using receiver operating characteristic curve analysis, a threshold of 50 HU was the optimal cutoff values to discriminate lipid pool from fibrosis. Lipid volume measured by MDCT was correlated with that measured by IB-IVUS (r =0.66, p <0.001), whereas fibrous volume was not (r =0.21, p =0.059).
Lipid volume measured by MDCT was moderately correlated with that measured by IB-IVUS. MDCT may be useful for volumetric assessment of the lipid volume of coronary plaques, whereas the assessment of fibrosis volume was unstable.
Ehara M, Surmely JF, Kawai M, Katoh O, Matsubara T, Terashima M, Tsuchikane E, Kinoshita Y, Suzuki T, Ito T, Takeda Y, Nasu K, Tanaka N, Murata A, Suzuki Y, Sato K, Suzuki T: Diagnostic accuracy of 64-slice computed tomography for detecting angiographically significant coronary artery stenosis in an unselected consecutive patient population: comparison with conventional invasive angiography. Circ J. 2006, 70: 564-571. 10.1253/circj.70.564 CrossRefPubMed
Hoffmann U, Moselewski F, Cury RC, Ferencik M, Jang IK, Diaz LJ, Abbara S, Brady TJ, Achenbach S: Predictive value of 16-slice multidetector spiral computed tomography to detect significant obstructive coronary artery disease in patients at high risk for coronary artery disease: patient-versus segment-based analysis. Circulation. 2004, 110: 2638-2643. 10.1161/01.CIR.0000145614.07427.9F CrossRefPubMed
Moselewski F, Ropers D, Pohle K, Hoffmann U, Ferencik M, Chan RC, Cury RC, Abbara S, Jang IK, Brady TJ, Daniel WG, Achenbach S: Measurement of cross-sectional coronary atherosclerotic plaques and vessel area by 16-slice multi-detector CT: Comparison to IVUS. Am J Cardiol. 2004, 94: 1294-1297. 10.1016/j.amjcard.2004.07.117 CrossRefPubMed
Hoffmann U, Moselewski F, Nieman K, Jang IK, Ferencik M, Rahman AM, Cury RC, Abbara S, Joneidi-Jafari H, Achenbach S, Brady TJ: Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography. J Am Coll Cardiol. 2006, 47: 1655-1662. 10.1016/j.jacc.2006.01.041 CrossRefPubMed
Motoyama S, Anno H, Sarai M, Sato T, Sanda Y, Ozaki Y, Mochizuki T, Katada K, Hishida H: Noninvasive coronary angiography with a prototype 256-row area detector computed tomography system: comparison with conventional invasive coronary angiography. J Am Coll Cardiol. 2008, 51: 773-775. 10.1016/j.jacc.2007.09.062 CrossRefPubMed
Leber AW, Knez A, Becker A, Becker C, von Ziegler F, Nikolaou K, Rist C, Reiser M, White C, Steinbeck G, Boekstegers P: Accuracy of multidetector spiral computed tomography in idetifing and differentiating the composition of coronary atherosclerotic plaques. A comparative study with intracoronary ultrasound. J Am Coll Cardiol. 2004, 43: 1241-1247. 10.1016/j.jacc.2003.10.059 CrossRefPubMed
Komatsu S, Imai A, Kodama K: Multidetector row computed tomography may accurately estimate plaque vulnerability. Circ J. 2011, 74: 1515-1521. CrossRef
Kawasaki M, Sano K, Okubo M, Yokoyama H, Ito Y, Murata I, Tsuchiya K, Minatoguchi S, Zhou X, Fujita H, Fujiwara H: Volumetric quantitative analysis of tissue characteristics of coronary plaques after statin therapy using three dimensional integrated backscatter intravascular ultrasound. J Am Coll Cardiol. 2005, 45: 1946-1953. 10.1016/j.jacc.2004.09.081 CrossRefPubMed
Kawasaki M, Takatsu H, Noda T, Sano K, Ito Y, Hayakawa K, Tsuchiya K, Arai M, Nishigaki K, Takemura G, Minatoguchi S, Fujiwara T, Fujiwara H: In vivo quantitative tissue characterization of human coronary arterial plaques by use of integrated backscatter intravascular ultrasound and comparison with angioscopic findings. Circulation. 2002, 105: 2487-2492. 10.1161/01.CIR.0000017200.47342.10 CrossRefPubMed
Sano K, Kawasaki M, Ishihara Y, Okubo M, Tsuchiya K, Nishigaki K, Zhou X, Minatoguchi S, Fujita H, Fujiwara H: Assessment of vulnerable plaques causing acute coronary syndrome using integrated backscatter intravascular ultrasound. J Am Coll Cardiol. 2006, 47: 734-741. 10.1016/j.jacc.2005.09.061 CrossRefPubMed
Okubo M, Kawasaki M, Ishihara Y, Takeyama U, Kubota T, Yamaki T, Ojio S, Nishigaki K, Takemura G, Saio M, Takami T, Minatoguchi S, Fujiwara H: Development of integrated backscatter intravascular ultrasound for tissue characterization of coronary plaques. Ultrasound Med Biol. 2008, 34: 655-663. 10.1016/j.ultrasmedbio.2007.09.015 CrossRefPubMed
Okubo M, Kawasaki M, Ishihara Y, Takeyama U, Yasuda S, Kubota T, Tanaka S, Yamaki T, Ojio S, Nishigaki K, Takemura G, Saio M, Takami T, Fujiwara H: Tissue characterization of coronary plaques. Comparison of integrated backscatter intravascular ultrasound with Virtual Histology intravascular ultrasound. Circ J. 2008, 72: 1631-1639. PubMed
Schroeder S, Kopp AF, Baumbach A, Meisner C, Kuettner A, Georg C, Ohnesorge B, Herdeg C, Claussen CD, Karsch KR: Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography. J Am Coll Cardiol. 2001, 37: 1430-1435. 10.1016/S0735-1097(01)01115-9 CrossRefPubMed
Kitagawa T, Yamamoto H, Ohhashi N, Okimoto T, Horiguchi J, Hirai N, Ito K, Kohno N: Comprehensive evaluation of noncalcified coronary plaque characteristics detected using 64-slice computed tomography in patients with proven or suspected coronary artery disease. Am Heart J. 2007, 154: 1191-1198. 10.1016/j.ahj.2007.07.020 CrossRefPubMed
Chopard R, Boussel L, Motreff P, Rioufol G, Tabib A, Douek P, Meyronet D, Revel D, Finet G: How reliable are 40 MHz IVUS and 64-slice MDCT in characterizing coronary plaque composition? An ex vivo study with histopathological comparison. Int J Cardiovasc Imaging. 2010, 26: 373-383. 10.1007/s10554-009-9562-y CrossRefPubMed
Harada K, Amano T, Uetani T, Funahashi H, Arai K, Okada K, Hirashiki A, Hayashi M, Oshima S, Ishii H, Izawa H, Matsubara T, Murohara T: Accuracy of 64-slice multidetector computed tomography for classification and quantitation of coronary plaque: Comparison with integrated backscatter intravascular ultrasound. Int J Cardiol. 2011, 149: 95-101. 10.1016/j.ijcard.2010.04.002 CrossRefPubMed
Tanaka A, Shimada K, Yoshida K, Jissyo S, Tanaka H, Sakamoto M, Matsuba K, Imanishi T, Akasaka T, Yoshikawa J: Non-invasive assessment of plaque rupture by 64-slice multidetector computed tomography-comparison with intravascular ultrasound. Circ J. 2008, 72: 1276-1281. 10.1253/circj.72.1276 CrossRefPubMed
Cademartiri F, Runza G, Mollet NR, Luccichenti G, Belgrano M, Somers P, Knaapen M, Verheye S, Bruining N, Hamers R, Midiri M, De Feyter PJ, Krestin GP: Influence of increasing convolution kernel filtering on plaque imaging with multislice CT using an ex-vivo model of coronary angiography. Radiol Med. 2005, 110: 234-240. PubMed
Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W, Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW: A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995, 92: 1355-1374. 10.1161/01.CIR.92.5.1355 CrossRefPubMed
Motoyama S, Kondo T, Sarai M, Sugiura A, Harigaya H, Sato T, Inoue K, Okumura M, Ishii J, Anno H, Virmani R, Ozaki Y, Hishida H, Narula J: Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes. J Am Coll Cardiol. 2007, 50: 319-326. 10.1016/j.jacc.2007.03.044 CrossRefPubMed
Kashiwagi M, Tanaka A, Kitabata H, Tsujioka H, Kataiwa H, Komukai K, Tanimoto T, Takemoto K, Takarada S, Kubo T, Hirata K, Nakamura N, Mizukoshi M, Imanishi T, Akasaka T: Feasibility of non-invasive assessment of thin-cap fibroatheroma by multidetector computed tomography. JACC Cardiovasc Imaging. 2009, 12: 1412-1419. CrossRef
Cademartiri F, Mollet NR, Runza G, Bruining N, Hamers R, Somers P, Knaapen M, Verheye S, Midiri M, Krestin GP, de Feyter PJ: Influence of intracoronary attenuation on coronary plaque measurements using multislice computed tomography: Observations in an ex vivo model of coronary computed tomography angiography. Eur Radiol. 2005, 15: 1426-1431. 10.1007/s00330-005-2697-x CrossRefPubMed
Halliburton SS, Schoenhagen P, Nair A, Stillman A, Lieber M: Murat Tuzcu E, Geoffrey Vince D, White RD: Contrast enhancement of coronary atherosclerotic plaque: a high-resolution, multidetector-row computed tomography study of pressure-perfused, human ex-vivo coronary arteries. Coron Artery Dis. 2006, 176: 553-560. CrossRef
- Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques
Owen Christopher Raffel
- BioMed Central
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