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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Cardiovascular Ultrasound 1/2012

Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques

Zeitschrift:
Cardiovascular Ultrasound > Ausgabe 1/2012
Autoren:
Takahiko Yamaki, Masanori Kawasaki, Ik-Kyung Jang, Owen Christopher Raffel, Yoshiyuki Ishihara, Munenori Okubo, Tomoki Kubota, Arihiro Hattori, Kazuhiko Nishigaki, Genzou Takemura, Hisayoshi Fujiwara, Shinya Minatoguchi
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1476-7120-10-33) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

TY, OCR and IKJ carried out subject recruitment and analyzed data. MK analyzed data and wrote the manuscript. YI, MO, and TK performed integrated backscatter ultrasound analysis. HF revised manuscript. AH, KN, GT and SM analyzed data. All authors read and approved the final manuscript.
We have no financial or other relations that could lead to conflict of interest.

Abstract

Background

The purpose of this study was to determine the cut-off values of Hounsfield units (HU) for the discrimination of plaque components and to evaluate the feasibility of measurement of the volume of plaque components using multi-detector row computed tomography (MDCT).

Methods

Coronary lesions (125 lesions in 125 patients) were visualized by both integrated backscatter intravascular ultrasound (IB-IVUS) and 64-slice MDCT at the same site. The IB values were used as a gold standard to determine the cut off values of HU for the discrimination of plaque components.

Results

Plaques were classified as lipid pool (n =50), fibrosis (n =65) or calcification (n =35) by IB-IVUS. The HU of lipid pool, fibrosis and calcification were 18 ± 18 HU (−19 to 58 HU), 95 ± 24 HU (46 to 154 HU) and 378 ± 99 HU (188 to 605 HU), respectively. Using receiver operating characteristic curve analysis, a threshold of 50 HU was the optimal cutoff values to discriminate lipid pool from fibrosis. Lipid volume measured by MDCT was correlated with that measured by IB-IVUS (r =0.66, p <0.001), whereas fibrous volume was not (r =0.21, p =0.059).

Conclusion

Lipid volume measured by MDCT was moderately correlated with that measured by IB-IVUS. MDCT may be useful for volumetric assessment of the lipid volume of coronary plaques, whereas the assessment of fibrosis volume was unstable.
Zusatzmaterial
Authors’ original file for figure 1
12947_2012_435_MOESM1_ESM.pdf
Authors’ original file for figure 2
12947_2012_435_MOESM2_ESM.pdf
Authors’ original file for figure 3
12947_2012_435_MOESM3_ESM.pdf
Authors’ original file for figure 4
12947_2012_435_MOESM4_ESM.pdf
Literatur
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