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Erschienen in: European Radiology 2/2019

23.07.2018 | Vascular-Interventional

Comparison of transjugular intrahepatic portosystemic shunt (TIPS) alone and combined with embolisation for the management of cardiofundal varices: a retrospective study

verfasst von: Jiaze Yu, Xiaoze Wang, Mingshan Jiang, Huaiyuan Ma, Zilin Zhou, Li Yang, Xiao Li

Erschienen in: European Radiology | Ausgabe 2/2019

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Abstract

Objectives

To assess the efficacy of transjugular intrahepatic portosystemic shunt (TIPS) with and without adjunctive embolisation in managing cardiofundal varices bleeding.

Methods

The retrospective study comprised 82 patients (54 men; mean age 53.9 years; mean Model of End-stage Liver Disease score 9.3) with cardiofundal varices bleeding who underwent TIPS creation from 2011 to 2015. Variceal rebleeding, the outflow tracts of varices, overt hepatic encephalopathy (HE) and post-procedure varices patency were assessed.

Results

Gastrorenal shunt was present in 92.7% of patients (n = 76). Embolisation was performed in 67.1% of patients (n = 55). The 1- and 2-year variceal rebleeding rates in the TIPS combined with embolisation group were significantly lower than those in the TIPS alone group (3.8% and 13.4% vs 13.0% and 28.0%, respectively; p = 0.041). No significant differences between the two groups were found in the cardiofundal varices patency, overt HE or survival (p > 0.05).

Conclusions

The results suggest that TIPS combined with embolisation can reduce the risk of variceal rebleeding for patients with cardiofundal varices.

Key Points

TIPS combined with embolisation reduces the risk of rebleeding in treating cardiofundal varices.
TIPS combined with embolisation could not completely occlude cardiofundal varices.
TIPS combined with embolisation could not prevent the development of hepatic encephalopathy.
Literatur
1.
2.
Zurück zum Zitat Dariushnia SR, Haskal ZJ, Midia M et al (2016) Quality improvement guidelines for transjugular intrahepatic portosystemic shunts. J Vasc Interv Radiol 27:1–7CrossRef Dariushnia SR, Haskal ZJ, Midia M et al (2016) Quality improvement guidelines for transjugular intrahepatic portosystemic shunts. J Vasc Interv Radiol 27:1–7CrossRef
3.
Zurück zum Zitat Krajina A, Hulek P, Fejfar T, Valek V (2012) Quality improvement guidelines for transjugular intrahepatic portosystemic shunt (TIPS). Cardiovasc Intervent Radiol 35:1295–1300CrossRef Krajina A, Hulek P, Fejfar T, Valek V (2012) Quality improvement guidelines for transjugular intrahepatic portosystemic shunt (TIPS). Cardiovasc Intervent Radiol 35:1295–1300CrossRef
4.
Zurück zum Zitat Xiao T, Chen L, Chen W et al (2011) Comparison of transjugular intrahepatic portosystemic shunt (TIPS) alone versus TIPS combined with embolotherapy in advanced cirrhosis: a retrospective study. J Clin Gastroenterol 45:643–650CrossRef Xiao T, Chen L, Chen W et al (2011) Comparison of transjugular intrahepatic portosystemic shunt (TIPS) alone versus TIPS combined with embolotherapy in advanced cirrhosis: a retrospective study. J Clin Gastroenterol 45:643–650CrossRef
5.
Zurück zum Zitat Qi X, Liu L, Bai M et al (2014) Transjugular intrahepatic portosystemic shunt in combination with or without variceal embolization for the prevention of variceal rebleeding: a meta-analysis. J Gastroenterol Hepatol 29:688–696CrossRef Qi X, Liu L, Bai M et al (2014) Transjugular intrahepatic portosystemic shunt in combination with or without variceal embolization for the prevention of variceal rebleeding: a meta-analysis. J Gastroenterol Hepatol 29:688–696CrossRef
6.
Zurück zum Zitat Chen S, Li X, Wei B et al (2013) Recurrent variceal bleeding and shunt patency: prospective randomized controlled trial of transjugular intrahepatic portosystemic shunt alone or combined with coronary vein embolization. Radiology 268:900–906CrossRef Chen S, Li X, Wei B et al (2013) Recurrent variceal bleeding and shunt patency: prospective randomized controlled trial of transjugular intrahepatic portosystemic shunt alone or combined with coronary vein embolization. Radiology 268:900–906CrossRef
7.
Zurück zum Zitat Gaba RC, Bui JT, Cotler SJ et al (2010) Rebleeding rates following TIPS for variceal hemorrhage in the Viatorr era: TIPS alone versus TIPS with variceal embolization. Hepatol Int 4:749–756CrossRef Gaba RC, Bui JT, Cotler SJ et al (2010) Rebleeding rates following TIPS for variceal hemorrhage in the Viatorr era: TIPS alone versus TIPS with variceal embolization. Hepatol Int 4:749–756CrossRef
8.
Zurück zum Zitat Garcia-Pagan JC, Barrufet M, Cardenas A, Escorsell A (2014) Management of gastric varices. Clin Gastroenterol Hepatol 12:919–928 e911; quiz e951-912CrossRef Garcia-Pagan JC, Barrufet M, Cardenas A, Escorsell A (2014) Management of gastric varices. Clin Gastroenterol Hepatol 12:919–928 e911; quiz e951-912CrossRef
9.
Zurück zum Zitat Sarin SK, Lahoti D, Saxena SP, Murthy NS, Makwana UK (1992) Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. Hepatology 16:1343–1349CrossRef Sarin SK, Lahoti D, Saxena SP, Murthy NS, Makwana UK (1992) Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. Hepatology 16:1343–1349CrossRef
10.
Zurück zum Zitat Tripathi D, Therapondos G, Jackson E, Redhead DN, Hayes PC (2002) The role of the transjugular intrahepatic portosystemic stent shunt (TIPSS) in the management of bleeding gastric varices: clinical and haemodynamic correlations. Gut 51:270–274CrossRef Tripathi D, Therapondos G, Jackson E, Redhead DN, Hayes PC (2002) The role of the transjugular intrahepatic portosystemic stent shunt (TIPSS) in the management of bleeding gastric varices: clinical and haemodynamic correlations. Gut 51:270–274CrossRef
11.
Zurück zum Zitat Stanley AJ, Jalan R, Ireland HM, Redhead DN, Bouchier IA, Hayes PC (1997) A comparison between gastric and oesophageal variceal haemorrhage treated with transjugular intrahepatic portosystemic stent shunt (TIPSS). Aliment Pharmacol Ther 11:171–176CrossRef Stanley AJ, Jalan R, Ireland HM, Redhead DN, Bouchier IA, Hayes PC (1997) A comparison between gastric and oesophageal variceal haemorrhage treated with transjugular intrahepatic portosystemic stent shunt (TIPSS). Aliment Pharmacol Ther 11:171–176CrossRef
12.
Zurück zum Zitat Jalan R, Redhead DN, Forrest EH, Hayes PC (1995) Relationship between directly measured portal pressure gradient and variceal hemorrhage. Am J Gastroenterol 90:1994–1996 Jalan R, Redhead DN, Forrest EH, Hayes PC (1995) Relationship between directly measured portal pressure gradient and variceal hemorrhage. Am J Gastroenterol 90:1994–1996
13.
Zurück zum Zitat Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J (2017) Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases. Hepatology 65:310–335CrossRef Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J (2017) Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases. Hepatology 65:310–335CrossRef
14.
Zurück zum Zitat Lakhoo J, Bui JT, Lokken RP, Ray CE Jr, Gaba RC (2016) Transjugular intrahepatic portosystemic shunt creation and variceal coil or plug embolization ineffectively attain gastric variceal decompression or occlusion: results of a 26-patient retrospective study. J Vasc Interv Radiol 27:1001–1011CrossRef Lakhoo J, Bui JT, Lokken RP, Ray CE Jr, Gaba RC (2016) Transjugular intrahepatic portosystemic shunt creation and variceal coil or plug embolization ineffectively attain gastric variceal decompression or occlusion: results of a 26-patient retrospective study. J Vasc Interv Radiol 27:1001–1011CrossRef
15.
Zurück zum Zitat Luo X, Wang Z, Tsauo J, Zhou B, Zhang H, Li X (2015) Advanced cirrhosis combined with portal vein thrombosis: a randomized trial of TIPS versus endoscopic band ligation plus propranolol for the prevention of recurrent esophageal variceal bleeding. Radiology 276:286–293CrossRef Luo X, Wang Z, Tsauo J, Zhou B, Zhang H, Li X (2015) Advanced cirrhosis combined with portal vein thrombosis: a randomized trial of TIPS versus endoscopic band ligation plus propranolol for the prevention of recurrent esophageal variceal bleeding. Radiology 276:286–293CrossRef
16.
Zurück zum Zitat Vilstrup H, Amodio P, Bajaj J et al (2014) Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology 60:715–735CrossRef Vilstrup H, Amodio P, Bajaj J et al (2014) Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology 60:715–735CrossRef
17.
Zurück zum Zitat Saad WE (2013) Vascular anatomy and the morphologic and hemodynamic classifications of gastric varices and spontaneous portosystemic shunts relevant to the BRTO procedure. Tech Vasc Interv Radiol 16:60–100CrossRef Saad WE (2013) Vascular anatomy and the morphologic and hemodynamic classifications of gastric varices and spontaneous portosystemic shunts relevant to the BRTO procedure. Tech Vasc Interv Radiol 16:60–100CrossRef
18.
Zurück zum Zitat Kiyosue H, Ibukuro K, Maruno M, Tanoue S, Hongo N, Mori H (2013) Multidetector CT anatomy of drainage routes of gastric varices: a pictorial review. Radiographics 33:87–100CrossRef Kiyosue H, Ibukuro K, Maruno M, Tanoue S, Hongo N, Mori H (2013) Multidetector CT anatomy of drainage routes of gastric varices: a pictorial review. Radiographics 33:87–100CrossRef
19.
Zurück zum Zitat Saad WE (2014) Combining transjugular intrahepatic portosystemic shunt with balloon-occluded retrograde transvenous obliteration or augmenting TIPS with variceal embolization for the management of gastric varices: an evolving middle ground? Semin Intervent Radiol 31:266–268CrossRef Saad WE (2014) Combining transjugular intrahepatic portosystemic shunt with balloon-occluded retrograde transvenous obliteration or augmenting TIPS with variceal embolization for the management of gastric varices: an evolving middle ground? Semin Intervent Radiol 31:266–268CrossRef
20.
Zurück zum Zitat Sanyal AJ, Freedman AM, Luketic VA et al (1997) The natural history of portal hypertension after transjugular intrahepatic portosystemic shunts. Gastroenterology 112:889–898CrossRef Sanyal AJ, Freedman AM, Luketic VA et al (1997) The natural history of portal hypertension after transjugular intrahepatic portosystemic shunts. Gastroenterology 112:889–898CrossRef
21.
Zurück zum Zitat Lakhoo J, Bui JT, Zivin SP et al (2015) Root cause analysis of rebleeding events following transjugular intrahepatic portosystemic shunt creation for variceal hemorrhage. J Vasc Interv Radiol 26:1444–1453CrossRef Lakhoo J, Bui JT, Zivin SP et al (2015) Root cause analysis of rebleeding events following transjugular intrahepatic portosystemic shunt creation for variceal hemorrhage. J Vasc Interv Radiol 26:1444–1453CrossRef
22.
Zurück zum Zitat Mukund A, Deogaonkar G, Rajesh S, Shasthry SM, Sarin SK (2017) Safety and efficacy of sodium tetradecyl sulfate and lipiodol foam in balloon-occluded retrograde transvenous obliteration (BRTO) for large porto-systemic shunts. Cardiovasc Intervent Radiol 40:1010–1016CrossRef Mukund A, Deogaonkar G, Rajesh S, Shasthry SM, Sarin SK (2017) Safety and efficacy of sodium tetradecyl sulfate and lipiodol foam in balloon-occluded retrograde transvenous obliteration (BRTO) for large porto-systemic shunts. Cardiovasc Intervent Radiol 40:1010–1016CrossRef
23.
Zurück zum Zitat Kobayakawa M, Kokubu S, Hirota S et al (2017) Short-term safety and efficacy of balloon-occluded retrograde transvenous obliteration using ethanolamine oleate: results of a prospective, multicenter, single-arm trial. J Vasc Interv Radiol 28:1108–1115CrossRef Kobayakawa M, Kokubu S, Hirota S et al (2017) Short-term safety and efficacy of balloon-occluded retrograde transvenous obliteration using ethanolamine oleate: results of a prospective, multicenter, single-arm trial. J Vasc Interv Radiol 28:1108–1115CrossRef
25.
Zurück zum Zitat Shi Y, Tian X, Hu J et al (2014) Efficacy of transjugular intrahepatic portosystemic shunt with adjunctive embolotherapy with cyanoacrylate for esophageal variceal bleeding. Dig Dis Sci 59:2325–2332CrossRef Shi Y, Tian X, Hu J et al (2014) Efficacy of transjugular intrahepatic portosystemic shunt with adjunctive embolotherapy with cyanoacrylate for esophageal variceal bleeding. Dig Dis Sci 59:2325–2332CrossRef
26.
Zurück zum Zitat Urbano J, Cabrera M, Alonso-Burgos A (2014) Sclerosis and varicocele embolization with N-butyl cyanoacrylate: experience in 41 patients. Acta Radiol 55:179–185CrossRef Urbano J, Cabrera M, Alonso-Burgos A (2014) Sclerosis and varicocele embolization with N-butyl cyanoacrylate: experience in 41 patients. Acta Radiol 55:179–185CrossRef
27.
Zurück zum Zitat Sze DY, Kao JS, Frisoli JK, McCallum SW, Kennedy WA 2nd, Razavi MK (2008) Persistent and recurrent postsurgical varicoceles: venographic anatomy and treatment with N-butyl cyanoacrylate embolization. J Vasc Interv Radiol 19:539–545CrossRef Sze DY, Kao JS, Frisoli JK, McCallum SW, Kennedy WA 2nd, Razavi MK (2008) Persistent and recurrent postsurgical varicoceles: venographic anatomy and treatment with N-butyl cyanoacrylate embolization. J Vasc Interv Radiol 19:539–545CrossRef
29.
Zurück zum Zitat Tesdal IK, Filser T, Weiss C, Holm E, Dueber C, Jaschke W (2005) Transjugular intrahepatic portosystemic shunts: adjunctive embolotherapy of gastroesophageal collateral vessels in the prevention of variceal rebleeding. Radiology 236:360–367CrossRef Tesdal IK, Filser T, Weiss C, Holm E, Dueber C, Jaschke W (2005) Transjugular intrahepatic portosystemic shunts: adjunctive embolotherapy of gastroesophageal collateral vessels in the prevention of variceal rebleeding. Radiology 236:360–367CrossRef
30.
Zurück zum Zitat Alkari B, Shaath NM, El-Dhuwaib Y et al (2005) Transjugular intrahepatic porto-systemic shunt and variceal embolisation in the management of bleeding stomal varices. Int J Colorectal Dis 20:457–462CrossRef Alkari B, Shaath NM, El-Dhuwaib Y et al (2005) Transjugular intrahepatic porto-systemic shunt and variceal embolisation in the management of bleeding stomal varices. Int J Colorectal Dis 20:457–462CrossRef
31.
Zurück zum Zitat Saad W, Darwish W, Davies M, Waldman D (2010) Stent-grafts for transjugular intrahepatic portosystemic shunt creation: specialized TIPS stent-graft versus generic stent-graft/bare stent combination. J Vasc Interv Radiol 21:1512–1520CrossRef Saad W, Darwish W, Davies M, Waldman D (2010) Stent-grafts for transjugular intrahepatic portosystemic shunt creation: specialized TIPS stent-graft versus generic stent-graft/bare stent combination. J Vasc Interv Radiol 21:1512–1520CrossRef
Metadaten
Titel
Comparison of transjugular intrahepatic portosystemic shunt (TIPS) alone and combined with embolisation for the management of cardiofundal varices: a retrospective study
verfasst von
Jiaze Yu
Xiaoze Wang
Mingshan Jiang
Huaiyuan Ma
Zilin Zhou
Li Yang
Xiao Li
Publikationsdatum
23.07.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 2/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5645-2

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