Background
Methods
Study population
Cine magnetic resonance protocol
Standard cine | CS cine | |
---|---|---|
ECG gating | Retrospective | Prospective |
TE/TR (ms) | 1.4/3.2 | 1.4/3.2 |
FOV (mm) | 350 × 350 | 350 × 350 |
Image matrix | 208 × 166 | 208 × 166 |
Spatial resolution (mm) | 1.7 × 1.7 | 1.7 × 1.7 |
Temporal resolution (ms) | 41 | 41 |
Slice thickness (mm) | 6 | 6 |
Flip angle | 50 | 50 |
Bandwidth (Hz/pixel) | 1145 | 960 |
Cardiac phases | 25 | 19–31 |
Breath-holds (n) | 4 | 1 |
Acceleration factor | 3 | 12.8 |
Iterative reconstruction | — | 80 |
Data acquisition and image reconstruction of the CS real-time cine
Qualitative image quality analysis
Quantitative LV volume analysis
Statistical analysis
Results
Image quality
Left ventricular function
Patients | Volunteers | |
---|---|---|
Number | 65 | 16 |
Age (y) | 70.9 ± 9.2 | 28.1 ± 4.4 |
Sex (female/male) | 18/47 | 4/12 |
Height (m) | 160.8 ± 9.5 | 166.9 ± 8.7 |
Weight (kg) | 62.1 ± 13.2 | 60.6 ± 10.7 |
BMI (kg/m2) | 23.8 ± 3.4 | 21.6 ± 2.2 |
HR (beats/min) | 62.2 ± 10.3 | 62.1 ± 8.6 |
Cardiovascular risk factor | ||
Hypertension | 36 (55 %) | — |
Dyslipidemia | 34 (52 %) | — |
Diabetes mellitus | 26 (40 %) | — |
Smoking | 16 (25 %) | — |
Family history of CAD | 9 (14 %) | — |
Cardiovascular disease | ||
CAD | 44 (68 %) | — |
Cardiomyopathy | 14 (22 %) | — |
Valve disease | 3 (5 %) | — |
Other | 4 (6 %) | — |
LVEF <50 % | 20 (31 %) | — |
Standard cine (n = 81) | CS cine (n = 81) |
p
| |
---|---|---|---|
LVEDV (mL) | 121.0 (105.8, 161.7) | 122.2 (103, 159) | 0.28 |
LVESV (mL) | 48.3 (34.8, 79.1) | 50.9 (32.9, 77.8) | 0.77 |
LVSV (mL) | 73.5 (63.8, 85.2) | 73.4 (63, 83.5) | 0.15 |
LV mass (g) | 82.3 (64.7, 101.3) | 80.4 (62.1, 99.0) | 0.15 |
LVEF (%) | 61.3 (50.5, 68.0) | 58.8 (50.7, 67.5) | 0.10 |
Difference (mean ± SD) | Variability [%] (mean ± SD) |
R
2
| Slope |
p
| |
---|---|---|---|---|---|
Intraobserver | |||||
LVEDV (mL) | 0.3 ± 11.6 | 1.0 ± 4.7 | 0.98 | 1.0 | <0.0001 |
LVESV (mL) | 0.4 ± 3.8 | 1.1 ± 7.0 | 0.99 | 0.99 | <0.0001 |
LVSV (mL) | 0.2 ± 11.1 | 1.6 ± 7.7 | 0.91 | 0.92 | <0.0001 |
LV mass (g) | −5.4 ± 9.4 | −4.8 ± 8.8 | 0.95 | 0.88 | <0.0001 |
LVEF (%) | 0.1 ± 2.9 | 0.7 ± 4.9 | 0.97 | 0.96 | <0.0001 |
Interobserver | |||||
LVEDV (mL) | 8.0 ± 5.8 | 6.4 ± 5.1 | 0.98 | 1.03 | <0.0001 |
LVESV (mL) | 1.7 ± 4.8 | 2.6 ± 9.8 | 0.99 | 1.03 | <0.0001 |
LVSV (mL) | 6.3 ± 6.0 | 9.3 ± 8.9 | 0.89 | 0.98 | <0.0001 |
LV mass (g) | −6.3 ± 11.5 | −7.3 ± 13.2 | 0.88 | 0.86 | <0.0001 |
LVEF (%) | 1.5 ± 3.4 | 2.9 ± 6.3 | 0.95 | 0.97 | <0.0001 |