Erschienen in:
01.12.2009 | Letter
Confirmation of local amino acid sequence homology between human prolactin and the amyloid-related proteins
verfasst von:
S. Benvenga, S. Cannavò, F. Trimarchi, F. Guarneri
Erschienen in:
Pituitary
|
Ausgabe 4/2009
Einloggen, um Zugang zu erhalten
Excerpt
In 2004, we had shown [
1] that prolactin shares with the fibrillar amyloid-related proteins (ARPs) conservation of the “Q, R, (X0–X3), L/V/I/M, (X0–X5),F/Y” motif (
QVT
LRD
F, aa 18–25 of the mature prolactin, corresponding to aa 33–40 of the precursor) as well as the C-terminal motif “R/K/H, (X0–X4), A, L/I, (X0–X6),G” (
HY
IHNLSSEMFSE, aa 33–45 of the mature prolactin, corresponding to aa 44–60 of the precursor). The motifs had been found [
2] based on a computer-assisted multiple alignment of 13 ARPs known at that time: amyloid β protein precursor (AβPP), apolipoprotein A-I, mouse apolipoprotein A-II, serum amyloid Aα, atrial natriuretic factor (ANF), calcitonin, cystatin C, gelsolin, immunoglobulins [Ig-λ, V–I region (Vor)], islet amyloid polypeptide (IAPP, also called amylin), β2-microglobulin, prion protein precursor and transthyretin. …
