Skip to main content
Erschienen in: Pituitary 3/2023

17.02.2023

Contemporary radiotherapy and radiosurgery techniques for refractory pituitary adenomas

verfasst von: Roman O. Kowalchuk, Daniel M. Trifiletti, Paul D. Brown, Jason P. Sheehan

Erschienen in: Pituitary | Ausgabe 3/2023

Einloggen, um Zugang zu erhalten

Abstract

The pituitary gland is a potential site for a range of pathologies, for which treatment can involve resection and/or ionizing radiation. Modern stereotactic radiosurgery (SRS) involves highly conformal radiation, allowing for the delivery of high doses to the tumor while simultaneously sparing nearby healthy structures. SRS has become a standard treatment option for residual or recurrent pituitary adenomas. It has been used for both functioning and nonfunctioning pituitary adenomas, with reported local tumor control over 90% and moderate rates of endocrine remission in functioning adenomas. We aim to briefly review the existing indictions and supporting literature for the use of SRS for refractory adenomas.
Literatur
1.
Zurück zum Zitat Kotecha R, Sahgal A, Rubens M, De Salles A, Fariselli L, Pollock BE et al (2020) Stereotactic radiosurgery for non-functioning pituitary adenomas: meta-analysis and International Stereotactic Radiosurgery Society practice opinion. Neurooncology 22(3):318–332 Kotecha R, Sahgal A, Rubens M, De Salles A, Fariselli L, Pollock BE et al (2020) Stereotactic radiosurgery for non-functioning pituitary adenomas: meta-analysis and International Stereotactic Radiosurgery Society practice opinion. Neurooncology 22(3):318–332
2.
Zurück zum Zitat Cohen-Inbar O, Xu Z, Lee C-c, Wu C-C, Chytka T, Silva D et al (2017) Prognostic significance of corticotroph staining in radiosurgery for non-functioning pituitary adenomas: a multicenter study. J Neurooncol 135(1):67–74CrossRefPubMed Cohen-Inbar O, Xu Z, Lee C-c, Wu C-C, Chytka T, Silva D et al (2017) Prognostic significance of corticotroph staining in radiosurgery for non-functioning pituitary adenomas: a multicenter study. J Neurooncol 135(1):67–74CrossRefPubMed
3.
Zurück zum Zitat Losa M, Spatola G, Albano L, Gandolfi A, Del Vecchio A, Bolognesi A et al (2017) Frequency, pattern, and outcome of recurrences after gamma knife radiosurgery for pituitary adenomas. Endocrine 56(3):595–602CrossRefPubMed Losa M, Spatola G, Albano L, Gandolfi A, Del Vecchio A, Bolognesi A et al (2017) Frequency, pattern, and outcome of recurrences after gamma knife radiosurgery for pituitary adenomas. Endocrine 56(3):595–602CrossRefPubMed
4.
Zurück zum Zitat Park K-J, Kano H, Parry PV, Niranjan A, Flickinger JC, Lunsford LD et al (2011) Long-term outcomes after gamma knife stereotactic radiosurgery for nonfunctional pituitary adenomas. Neurosurgery 69(6):1188–1199CrossRefPubMed Park K-J, Kano H, Parry PV, Niranjan A, Flickinger JC, Lunsford LD et al (2011) Long-term outcomes after gamma knife stereotactic radiosurgery for nonfunctional pituitary adenomas. Neurosurgery 69(6):1188–1199CrossRefPubMed
5.
Zurück zum Zitat Sheehan JP, Starke RM, Mathieu D, Young B, Sneed PK, Chiang VL et al (2013) Gamma Knife radiosurgery for the management of nonfunctioning pituitary adenomas: a multicenter study. J Neurosurg 119(2):446–456CrossRefPubMed Sheehan JP, Starke RM, Mathieu D, Young B, Sneed PK, Chiang VL et al (2013) Gamma Knife radiosurgery for the management of nonfunctioning pituitary adenomas: a multicenter study. J Neurosurg 119(2):446–456CrossRefPubMed
6.
Zurück zum Zitat Dutta SW, Kowalchuk RO, Trifiletti DM, Peach MS, Sheehan JP, Larner JM et al (2018) Stereotactic shifts during frame-based image-guided stereotactic radiosurgery: clinical measurements. Int J Radiat Oncol Biol Phys 102(4):895–902CrossRefPubMed Dutta SW, Kowalchuk RO, Trifiletti DM, Peach MS, Sheehan JP, Larner JM et al (2018) Stereotactic shifts during frame-based image-guided stereotactic radiosurgery: clinical measurements. Int J Radiat Oncol Biol Phys 102(4):895–902CrossRefPubMed
7.
Zurück zum Zitat Kowalchuk RO, Niranjan A, Lee C-C, Yang H-C, Liscak R, Guseynova K et al (2022) Reirradiation with Stereotactic Radiosurgery after local or marginal recurrence of Brain Metastases from previous Radiosurgery. Int J Radiat Oncol Biol Phys 112(3):726–734CrossRefPubMed Kowalchuk RO, Niranjan A, Lee C-C, Yang H-C, Liscak R, Guseynova K et al (2022) Reirradiation with Stereotactic Radiosurgery after local or marginal recurrence of Brain Metastases from previous Radiosurgery. Int J Radiat Oncol Biol Phys 112(3):726–734CrossRefPubMed
8.
Zurück zum Zitat Kowalchuk RO, Shepard MJ, Sheehan K, Sheehan D, Faramand A, Niranjan A et al (2021) Treatment of WHO Grade 2 Meningiomas with Stereotactic Radiosurgery: identification of an Optimal Group for SRS using RPA. Int J Radiation Oncology* Biology* Phys 110(3):804–814CrossRef Kowalchuk RO, Shepard MJ, Sheehan K, Sheehan D, Faramand A, Niranjan A et al (2021) Treatment of WHO Grade 2 Meningiomas with Stereotactic Radiosurgery: identification of an Optimal Group for SRS using RPA. Int J Radiation Oncology* Biology* Phys 110(3):804–814CrossRef
9.
Zurück zum Zitat Kowalchuk RO, Niranjan A, Hess J, Antonios JP, Zhang MY, Braunstein S et al (2022) Stereotactic radiosurgery and local control of brain metastases from triple-negative breast cancer.Journal of Neurosurgery. :1–7 Kowalchuk RO, Niranjan A, Hess J, Antonios JP, Zhang MY, Braunstein S et al (2022) Stereotactic radiosurgery and local control of brain metastases from triple-negative breast cancer.Journal of Neurosurgery. :1–7
10.
Zurück zum Zitat Jette D, Chen W (2011) Creating a spread-out Bragg peak in proton beams. Phys Med Biol 56(11):N131CrossRefPubMed Jette D, Chen W (2011) Creating a spread-out Bragg peak in proton beams. Phys Med Biol 56(11):N131CrossRefPubMed
11.
Zurück zum Zitat Loeffler JS, Shih HA (2011) Radiation Therapy in the management of Pituitary Adenomas. J Clin Endocrinol Metabolism 96(7):1992–2003CrossRef Loeffler JS, Shih HA (2011) Radiation Therapy in the management of Pituitary Adenomas. J Clin Endocrinol Metabolism 96(7):1992–2003CrossRef
12.
Zurück zum Zitat Kowalchuk RO, Trifiletti DM, Brown PD, Sheehan JP (2022) Radiotherapy in the Management of Pituitary Adenomas. The Pituitary. :753 – 64 Kowalchuk RO, Trifiletti DM, Brown PD, Sheehan JP (2022) Radiotherapy in the Management of Pituitary Adenomas. The Pituitary. :753 – 64
13.
Zurück zum Zitat Sheehan JP, Xu Z, Salvetti DJ, Schmitt PJ, Vance ML (2013) Results of Gamma Knife surgery for Cushing’s disease. J Neurosurg 119(6):1486–1492CrossRefPubMed Sheehan JP, Xu Z, Salvetti DJ, Schmitt PJ, Vance ML (2013) Results of Gamma Knife surgery for Cushing’s disease. J Neurosurg 119(6):1486–1492CrossRefPubMed
14.
Zurück zum Zitat Pollock BE, Jacob JT, Brown PD, Nippoldt TB (2007) Radiosurgery of growth hormone–producing pituitary adenomas: factors associated with biochemical remission. J Neurosurg 106(5):833–838CrossRefPubMed Pollock BE, Jacob JT, Brown PD, Nippoldt TB (2007) Radiosurgery of growth hormone–producing pituitary adenomas: factors associated with biochemical remission. J Neurosurg 106(5):833–838CrossRefPubMed
15.
Zurück zum Zitat Zhang N, Pan L, Wang EM, Dai JZ, Wang BJ, Cai PW (2000) Radiosurgery for growth hormone—producing pituitary adenomas. J Neurosurg 93(supplement3):6–9CrossRefPubMed Zhang N, Pan L, Wang EM, Dai JZ, Wang BJ, Cai PW (2000) Radiosurgery for growth hormone—producing pituitary adenomas. J Neurosurg 93(supplement3):6–9CrossRefPubMed
16.
Zurück zum Zitat Ding D, Mehta GU, Patibandla MR, Lee C-C, Liscak R, Kano H et al (2019) Stereotactic radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study. Neurosurgery 84(3):717–725CrossRefPubMed Ding D, Mehta GU, Patibandla MR, Lee C-C, Liscak R, Kano H et al (2019) Stereotactic radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study. Neurosurgery 84(3):717–725CrossRefPubMed
17.
Zurück zum Zitat Pan L, Zhang N, Wang EM, Wang BJ, Dai JZ, Cai PW (2000) Gamma knife radiosurgery as a primary treatment for prolactinomas. J Neurosurg 93(supplement3):10–13CrossRefPubMed Pan L, Zhang N, Wang EM, Wang BJ, Dai JZ, Cai PW (2000) Gamma knife radiosurgery as a primary treatment for prolactinomas. J Neurosurg 93(supplement3):10–13CrossRefPubMed
18.
Zurück zum Zitat Verma J, McCutcheon IE, Waguespack SG, Mahajan A (2014) Feasibility and outcome of re-irradiation in the treatment of multiply recurrent pituitary adenomas. Pituitary 17:539–545CrossRefPubMed Verma J, McCutcheon IE, Waguespack SG, Mahajan A (2014) Feasibility and outcome of re-irradiation in the treatment of multiply recurrent pituitary adenomas. Pituitary 17:539–545CrossRefPubMed
19.
Zurück zum Zitat Xu Z, Ellis S, Lee C-C, Starke RM, Schlesinger D, Vance ML et al (2014) Silent corticotroph adenomas after stereotactic radiosurgery: a case-control study. Int J Radiat Oncol Biol Phys 15:903–910CrossRef Xu Z, Ellis S, Lee C-C, Starke RM, Schlesinger D, Vance ML et al (2014) Silent corticotroph adenomas after stereotactic radiosurgery: a case-control study. Int J Radiat Oncol Biol Phys 15:903–910CrossRef
20.
Zurück zum Zitat Dumot C, Schlesinger D, Mantziaris G, Dayawansa S, Xu Z, Sheehan JP (2022) Role of biological effective dose for prediction of endocrine remission in acromegaly patients treated with stereotactic radiosurgery.Pituitary. Dumot C, Schlesinger D, Mantziaris G, Dayawansa S, Xu Z, Sheehan JP (2022) Role of biological effective dose for prediction of endocrine remission in acromegaly patients treated with stereotactic radiosurgery.Pituitary.
21.
Zurück zum Zitat Minniti G, Paolini S, Rea MLJ, Isidori A, Scaringi C, Russo I et al (2020) Stereotactic reirradiation with temozolomide in patients with recurrent aggressive pituitary tumors and pituitary carcinomas. J Neurooncol 149(1):123–130CrossRefPubMed Minniti G, Paolini S, Rea MLJ, Isidori A, Scaringi C, Russo I et al (2020) Stereotactic reirradiation with temozolomide in patients with recurrent aggressive pituitary tumors and pituitary carcinomas. J Neurooncol 149(1):123–130CrossRefPubMed
22.
Zurück zum Zitat Marek J, Jezkova J, Hana V, Krsek M, Bandúrová Lu, Pecen L et al (2011) Is it possible to avoid hypopituitarism after irradiation of pituitary adenomas by the Leksell gamma knife? Eur J Endocrinol 164(2):169CrossRefPubMed Marek J, Jezkova J, Hana V, Krsek M, Bandúrová Lu, Pecen L et al (2011) Is it possible to avoid hypopituitarism after irradiation of pituitary adenomas by the Leksell gamma knife? Eur J Endocrinol 164(2):169CrossRefPubMed
23.
Zurück zum Zitat Patel TR, Chiang VLS (2014) Secondary neoplasms after stereotactic radiosurgery. World Neurosurg 81:594–599CrossRefPubMed Patel TR, Chiang VLS (2014) Secondary neoplasms after stereotactic radiosurgery. World Neurosurg 81:594–599CrossRefPubMed
24.
Zurück zum Zitat Wolf A, Naylor K, Tam M, Habibi A, Novotny J, Liscak R et al (2019) Risk of radiation-associated intracranial malignancy after stereotactic radiosurgery: a retrospective, multicentre, cohort study. Lancet Oncol 20:159–164CrossRefPubMed Wolf A, Naylor K, Tam M, Habibi A, Novotny J, Liscak R et al (2019) Risk of radiation-associated intracranial malignancy after stereotactic radiosurgery: a retrospective, multicentre, cohort study. Lancet Oncol 20:159–164CrossRefPubMed
Metadaten
Titel
Contemporary radiotherapy and radiosurgery techniques for refractory pituitary adenomas
verfasst von
Roman O. Kowalchuk
Daniel M. Trifiletti
Paul D. Brown
Jason P. Sheehan
Publikationsdatum
17.02.2023
Verlag
Springer US
Erschienen in
Pituitary / Ausgabe 3/2023
Print ISSN: 1386-341X
Elektronische ISSN: 1573-7403
DOI
https://doi.org/10.1007/s11102-023-01300-z

Weitere Artikel der Ausgabe 3/2023

Pituitary 3/2023 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Erhöhte Mortalität bei postpartalem Brustkrebs

07.05.2024 Mammakarzinom Nachrichten

Auch für Trägerinnen von BRCA-Varianten gilt: Erkranken sie fünf bis zehn Jahre nach der letzten Schwangerschaft an Brustkrebs, ist das Sterberisiko besonders hoch.

Hypertherme Chemotherapie bietet Chance auf Blasenerhalt

07.05.2024 Harnblasenkarzinom Nachrichten

Eine hypertherme intravesikale Chemotherapie mit Mitomycin kann für Patienten mit hochriskantem nicht muskelinvasivem Blasenkrebs eine Alternative zur radikalen Zystektomie darstellen. Kölner Urologen berichten über ihre Erfahrungen.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Medizinstudium Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Vorhofflimmern bei Jüngeren gefährlicher als gedacht

06.05.2024 Vorhofflimmern Nachrichten

Immer mehr jüngere Menschen leiden unter Vorhofflimmern. Betroffene unter 65 Jahren haben viele Risikofaktoren und ein signifikant erhöhtes Sterberisiko verglichen mit Gleichaltrigen ohne die Erkrankung.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.