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European Archives of Oto-Rhino-Laryngology

Erschienen in:

05.01.2021 | Laryngology

Contribution of narrow band imaging in delineation of laryngopharyngeal superficial cancer spread: a prospective study

verfasst von: Emilien Chabrillac, Gaël Espinasse, Benoît Lepage, Emmanuelle Uro-Coste, Agnès Dupret-Bories, Guillaume De Bonnecaze, Sébastien Vergez

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 5/2021

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Abstract

Purpose

The aim of this study was to assess the performance of Narrow Band Imaging (NBI) added to White Light (WL) in the delineation of laryngopharyngeal superficial cancer spread during office-based transnasal flexible endoscopy.

Methods

This bi-centric prospective study was conducted between October 2014 and December 2017. We included consecutive patients with laryngopharyngeal malignant tumors. Transnasal flexible endoscopy was performed by two endoscopists who were blinded to each other's assessments and who examined each patient independently. The first endoscopist only performed a WL examination, while the second endoscopist carried out both WL and NBI. The extent of tumor involvement was reported based on predefined anatomical sub-units. Biopsies in NBI + /WL− sub-units were subsequently performed during panendoscopy.

Results

Eighty-four patients were included in the study. A total of 72 NBI + /WL− sub-units were sampled in 38 patients, and 37 of the biopsies were positive (51.4%): 16 for invasive carcinoma, 17 for high-grade dysplasia/carcinoma in situ and 4 for low-grade dysplasia. Ultimately, 26.2% of patients had at least one positive biopsy in an NBI + /WL− sub-unit and, therefore, a better tumor delineation. The clinical T stage was upgraded in 4.8% of cases examined.

Conclusion

Adding NBI to WL imaging during transnasal flexible endoscopy in patients presenting with laryngopharyngeal pre-malignant or malignant lesions improves the delineation of superficial cancer spread, thereby leading to better adapted treatments.

Clinicaltrials.gov registration number: NCT02035735.

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Titel: Contribution of narrow band imaging in delineation of laryngopharyngeal superficial cancer spread: a prospective study
verfasst von: Emilien Chabrillac
Gaël Espinasse
Benoît Lepage
Emmanuelle Uro-Coste
Agnès Dupret-Bories
Guillaume De Bonnecaze
Sébastien Vergez
Publikationsdatum: 05.01.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 5/2021
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-06499-2

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Contribution of narrow band imaging in delineation of laryngopharyngeal superficial cancer spread: a prospective study