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Current Hypertension Reports

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01.03.2018 | Hypertension and the Kidney (RM Carey, Section Editor)

Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin

verfasst von: Lisa L. Morselli, Kristin E. Claflin, Huxing Cui, Justin L. Grobe

Erschienen in: Current Hypertension Reports | Ausgabe 3/2018

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Abstract

Purpose of Review

Here, we review the current understanding of the functional neuroanatomy of neurons expressing Agouti-related peptide (AgRP) and the angiotensin 1A receptor (AT_1A) within the arcuate nucleus (ARC) in the control of energy balance.

Recent Findings

The development and maintenance of obesity involves suppression of resting metabolic rate (RMR). RMR control is integrated via AgRP and proopiomelanocortin neurons within the ARC. Their projections to other hypothalamic and extrahypothalamic nuclei contribute to RMR control, though relatively little is known about the contributions of individual projections and the neurotransmitters involved. Recent studies highlight a role for AT_1A, localized to AgRP neurons, but the specific function of AT_1A within these cells remains unclear.

Summary

AT_1A functions within AgRP neurons to control RMR, but additional work is required to clarify its role within subpopulations of AgRP neurons projecting to distinct second-order nuclei, and the molecular mediators of its signaling within these cells.

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Titel: Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin
verfasst von: Lisa L. Morselli
Kristin E. Claflin
Huxing Cui
Justin L. Grobe
Publikationsdatum: 01.03.2018
Verlag: Springer US
Erschienen in: Current Hypertension Reports / Ausgabe 3/2018
Print ISSN: 1522-6417
Elektronische ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-018-0824-8

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