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23.02.2016 | Nephrology - Original Paper

Correlation between nonalcoholic fatty liver and cardiovascular disease in elderly hemodialysis patients

verfasst von: Radojica V. Stolic, Goran Z. Trajkovic, Mirjana M. Kostic, Sasa R. Sovtic, Andrijana M. Odalovic, Biljana D. Krdzic, Maja V. Sipic, Snezana Lazic, Zorica N. Sojevic-Timotijevic

Erschienen in: International Urology and Nephrology | Ausgabe 6/2016

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Abstract

Purpose

The number of elderly patients with end-stage kidney disease is on the rise. Nonalcoholic fatty liver disease (NAFLD) is characterized by parenchymal fat accumulation in patients without information about alcohol abuse. The aim of our study was to determine correlation between NAFLD and cardiovascular diseases in elderly hemodialysis patients.

Methods

The examination was organized as observational and cross-sectional study in elderly patients on hemodialysis. An abdominal ultrasound examination was made in order to define NAFLD. Intima-media thickness of the carotid arteries was quantified by Doppler ultrasound. Biochemical parameters, gender, anthropometric characteristics, duration, adequacy of hemodialysis, blood pressure, smoking and cardiovascular disease were determined. Respondents were divided into a group with NAFLD (37/72 patients, 51 %) and group without NAFLD (35/72 patients, 49 %).

Results

Patients with NAFLD have significantly more cardiovascular disease (p = 0.017) as well as significantly higher values of intima-media thickness of the carotid arteries (p = 0.03) in correlation with patients without NAFLD. Patients without NAFLD have a statistically lower triglyceride (p = 0.04), aspartate aminotransferase (p = 0.006), alanine aminotransferase (p = 0.013) and gamma-glutamyl transpeptidase (p = 0.029) compared to patients with NAFLD. Patients with cardiovascular disease have a higher risk of NAFLD; likewise, patients with NAFLD have a three times higher chance for developing cardiovascular diseases (OR 3.01).

Conclusion

Elderly patients on hemodialysis with cardiovascular disease have a higher risk of NAFLD; likewise, patients with NAFLD have a three times higher chance for developing cardiovascular diseases.

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Titel: Correlation between nonalcoholic fatty liver and cardiovascular disease in elderly hemodialysis patients
verfasst von: Radojica V. Stolic
Goran Z. Trajkovic
Mirjana M. Kostic
Sasa R. Sovtic
Andrijana M. Odalovic
Biljana D. Krdzic
Maja V. Sipic
Snezana Lazic
Zorica N. Sojevic-Timotijevic
Publikationsdatum: 23.02.2016
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 6/2016
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-016-1237-8

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Correlation between nonalcoholic fatty liver and cardiovascular disease in elderly hemodialysis patients