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Erschienen in: Journal of Cancer Research and Clinical Oncology 10/2011

01.10.2011 | Original Paper

Correlation between the expression of the BAG-1 gene and clinicopathologic factors in colorectal cancer

verfasst von: Nian-Feng Sun, Qing-Yi Meng, San-Yuan Hu, Ai-Ling Tian, Rui-Hua Wang, Zhao-Xuan Liu, Li Xu

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 10/2011

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Abstract

Objective

The present study aims to investigate the expression and significance of the anti-apoptotic gene Bag-1 in colorectal cancer and to evaluate the relationship between the gene and the disease.

Methods

Bag-1 expression was examined in 320 colorectal cancer and 30 normal colorectal tissue samples using reverse transcriptase polymerase chain reaction (RT-PCR) and the immunohistochemical staining (streptavidin–biotin-peroxidase complex method.

Results

Using RT-PCR, Bag-1 was observed to be expressed in colorectal cancer tissues, but not in normal colorectal tissues. The expression of Bag-1 in colorectal cancer was closely correlated with pathologic grade, distant metastasis, Dukes stage, and prognosis, but it was not correlated with the pathologic type, tumor diameter, depth of invasion, and lymph node metastasis.

Conclusion

Bag-1 protein was found to be overexpressed in colorectal cancer. They might be regarded as a biomarker for the diagnosis of the early stages of colorectal cancer. In addition, they have particular significance for the prognosis of colorectal cancer.
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Metadaten
Titel
Correlation between the expression of the BAG-1 gene and clinicopathologic factors in colorectal cancer
verfasst von
Nian-Feng Sun
Qing-Yi Meng
San-Yuan Hu
Ai-Ling Tian
Rui-Hua Wang
Zhao-Xuan Liu
Li Xu
Publikationsdatum
01.10.2011
Verlag
Springer-Verlag
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 10/2011
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-011-1011-3

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