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Japanese Journal of Radiology
Erschienen in: Japanese Journal of Radiology 6/2021

28.01.2021 | Original Article

Could both intrinsic and extrinsic iodine be successfully suppressed on virtual non-contrast CT images for detecting thyroid calcification?

verfasst von: Arim Park, Young Hen Lee, Hyung Suk Seo

Erschienen in: Japanese Journal of Radiology | Ausgabe 6/2021

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Abstract

Purpose

Although virtual non-contrast (VNC) successfully removes iodinated contrast, uncertainty exists regarding the feasibility of VNC to suppress iodine for detecting thyroid calcification. Therefore, we evaluated whether both intrinsic and extrinsic iodine attenuation were suppressed on VNC images.

Material and methods

We enrolled 128 patients (male: female 17:111; age 48.0 ± 10.4 years) who underwent dual-layer dual-energy CT (DL-DECT) examination before their thyroid cancer surgeries. Two additional sets of VNC (VNCu, VNCc) images were retrospectively generated from their true unenhanced (TUE) and true contrast-enhanced (TCE) series. We compared CT attenuation values measured on the VNCu and VNCc images by drawing identical regions of interest encompassing thyroid parenchyma, then subjectively determined the concordance of calcification.

Results

Although CT attenuation discrepancies between the VNCu and VNCc were significant (2.0 ± 5.7HU, p < 0.001),61.7%, 89.1%, and 100.0% of all measurements were < 5HU, < 10HU, and < 15HU. Based on Bland–Altman analysis, the limits of agreement were − 9.2HU and 13.2HU, whereas the proportional differences were small for VNC images generated from both TUE and TCE images. There was no discordance between two VNC image sets in detecting thyroid calcification.

Conclusions

VNC technique could be a feasible method to suppress both intrinsic and extrinsically administered iodine for detecting thyroid calcification
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Metadaten
Titel
Could both intrinsic and extrinsic iodine be successfully suppressed on virtual non-contrast CT images for detecting thyroid calcification?
verfasst von
Arim Park
Young Hen Lee
Hyung Suk Seo
Publikationsdatum
28.01.2021
Verlag
Springer Singapore
Erschienen in
Japanese Journal of Radiology / Ausgabe 6/2021
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-021-01095-8

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