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Current Allergy and Asthma Reports

Erschienen in:

01.06.2021 | COVID-19 | Rhinosinusitis (J Mullol, Section Editor) Zur Zeit gratis

Clinical-Pathological Correlation of the Pathophysiology and Mechanism of Action of COVID-19 — a Primer for Clinicians

verfasst von: Jeremy Chee, Woei Shyang Loh, Zheng Liu, Joaquim Mullol, De Yun Wang

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 6/2021

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Abstract

Purpose of Review

Increasing knowledge of the pathogenesis of the SARS-CoV-2 infection and the complex interaction between host and viral factors have allowed clinicians to stratify the severity of COVID-19 infection. Epidemiological data has also helped to model viral carriage and infectivity. This review presents a comprehensive summary of the pathophysiology of COVID-19, the mechanisms of action of the SARS-CoV-2 virus, and the correlation with the clinical and biochemical characteristics of the disease.

Recent Findings

ACE2 and TMPRSS2 receptors have emerged as a key player in the mechanism of infection of SARS-CoV-2. Their distribution throughout the body has been shown to impact the organ-specific manifestations of COVID-19. The immune-evasive and subsequently immunoregulative properties of SARS-CoV-2 are also shown to be implicated in disease proliferation and progression.

Summary

Information gleaned from the virological properties of SARS-CoV-2 is consistent with and reflects the clinical behavior of the COVID-19 infection. Further study of specific clinical phenotypes and severity classes of COVID-19 may assist in the development of targeted therapeutics to halt progression of disease from mild to moderate-severe. As the understanding of the pathophysiology and mechanism of action of SARS-CoV-2 continues to grow, it is our hope that better and more effective treatment options continue to emerge.

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Titel: Clinical-Pathological Correlation of the Pathophysiology and Mechanism of Action of COVID-19 — a Primer for Clinicians
verfasst von: Jeremy Chee
Woei Shyang Loh
Zheng Liu
Joaquim Mullol
De Yun Wang
Publikationsdatum: 01.06.2021
Verlag: Springer US
Schlagwort: COVID-19
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 6/2021
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-021-01015-w

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Springer Medizin

Clinical-Pathological Correlation of the Pathophysiology and Mechanism of Action of COVID-19 — a Primer for Clinicians

Abstract

Purpose of Review

Recent Findings

Summary

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Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

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