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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

24.04.2020 | COVID-19 | Review Zur Zeit gratis

The genetic sequence, origin, and diagnosis of SARS-CoV-2

verfasst von: Huihui Wang, Xuemei Li, Tao Li, Shubing Zhang, Lianzi Wang, Xian Wu, Jiaqing Liu

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 9/2020

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Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new infectious disease that first emerged in Hubei province, China, in December 2019, which was found to be associated with a large seafood and animal market in Wuhan. Airway epithelial cells from infected patients were used to isolate a novel coronavirus, named the SARS-CoV-2, on January 12, 2020, which is the seventh member of the coronavirus family to infect humans. Phylogenetic analysis of full-length genome sequences obtained from infected patients showed that SARS-CoV-2 is similar to severe acute respiratory syndrome coronavirus (SARS-CoV) and uses the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2), as SARS-CoV. The possible person-to-person disease rapidly spread to many provinces in China as well as other countries. Without a therapeutic vaccine or specific antiviral drugs, early detection and isolation become essential against novel Coronavirus. In this review, we introduced current diagnostic methods and criteria for the SARS-CoV-2 in China and discuss the advantages and limitations of the current diagnostic methods, including chest imaging and laboratory detection.

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Titel: The genetic sequence, origin, and diagnosis of SARS-CoV-2
verfasst von: Huihui Wang
Xuemei Li
Tao Li
Shubing Zhang
Lianzi Wang
Xian Wu
Jiaqing Liu
Publikationsdatum: 24.04.2020
Verlag: Springer Berlin Heidelberg
Schlagwörter: COVID-19
Diagnostik in der Infektiologie
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 9/2020
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-020-03899-4

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