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Irish Journal of Medical Science (1971 -)

Erschienen in:

10.08.2021 | COVID-19 | Original Article Zur Zeit gratis

Correlation of olfactory dysfunction with lung involvement and severity of COVID-19

verfasst von: Ali R. Yağmur, Şeyda Akbal Çufalı, Adalet Aypak, Murathan Köksal, Yasin C. Güneş, Kürşat M. Özcan

Erschienen in: Irish Journal of Medical Science (1971 -) | Ausgabe 4/2022

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Abstract

Background

Olfactory dysfunction (OD) is a significant symptom of COVID-19 and may be the earliest symptom, or it may sometimes be the only manifestation of the disease.

Aims

To investigate whether OD is correlated with chest computed tomography (CT) findings, blood test parameters, and disease severity in COVID-19 patients.

Methods

The files of COVID-19 patients were retrospectively reviewed, and the ones who had information about smelling status and CT were taken into consideration. A total of 180 patients were divided into two groups: the OD group consisted of 89 patients with self-reported OD, and the No-OD group consisted of 91 subjects who did not complain of OD. The two groups were compared for the amount of lung consolidation on CT, intensive care unit (ICU) admission, and blood test parameters (complete blood count, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), ferritin, D-dimer, interleukin-6 (IL-6)).

Results

The amount of lung consolidation and ICU admission were significantly higher in the No-OD group (p < 0.001 for both). White blood cell (p = 0.06), monocyte (p = 0.26), and platelet (p = 0.13) counts and hemoglobin (p = 0.63), ALT (p = 0.89), and D-dimer (p = 0.45) levels of the two groups were similar. Lymphocyte count (p = 0.01), neutrophil count (p = 0.01), and AST (p = 0.03), CK (p = 0.01), LDH (p < 0.001), CRP (p < 0.001), ESR (p < 0.001), ferritin (p < 0.001), and IL-6 (p < 0.001) levels were significantly higher in the No-OD group.

Conclusions

The patients presenting to the hospital with self-reported OD may have less lung involvement and a milder disease course compared to patients without OD on admission.

Lv M, Wang M, Yang N et al (2020) Chest computed tomography for the diagnosis of patients with coronavirus disease 2019 (COVID-19): a rapid review and meta-analysis. Ann Transl Med 8:622CrossRef

Zhang L, Guo H (2020) Biomarkers of COVID-19 and technologies to combat SARSCoV-2. Advances in Biomarker Sciences and Technology 2:1–23CrossRef

Allis TJ, Leopold DA (2012) Smell and taste disorders. Facial Plast Surg Clin North Am 20:93–111CrossRef

Suzuki M, Saito K, Min WP et al (2007) Identification of viruses in patients with postviral olfactory dysfunction. Laryngoscope 117:272–277CrossRef

Anosmia, hyposmia, and dysgeusia symptoms of coronavirus disease (2020) American Academy Otolaryngology - Head and Neck Surgery. https://www.entnet.org/content/aao-hns-anosmia-hyposmia-and-dysgeusia-symptoms-coronavirus-disease. Accessed 5 April 2020

Ibekwe TS, Fasunla AJ, Orimadegun AE (2020) Systematic review and meta-analysis of smell and taste disorders in COVID-19. OTO Open 4:2473974X20957975

Printza A, Constantinidis J (2020) The role of self-reported smell and taste disorders in suspected COVID-19. Eur Arch Otorhinolaryngol 277:2625–2630CrossRef

Mazzatenta A, Neri G, D'Ardes D et al (2020) Smell and taste in severe CoViD-19: self-reported vs. testing. Front Med (Lausanne) 7:589409

Grassi R, Cappabianca S, Urraro F et al (2020) Chest CT computerized aided quantification of PNEUMONIA lesions in COVID-19 infection: a comparison among three commercial software. Int J Environ Res Public Health 17

10.

Machhi J, Herskovitz J, Senan AM et al (2020) The natural history, pathobiology, and clinical manifestations of SARS-CoV-2 infections. J Neuroimmune Pharmacol 15:359–386CrossRef

11.

Wu J, Wu X, Zeng W et al (2020) Chest CT findings in patients with coronavirus disease 2019 and its relationship with clinical features. Invest Radiol 55:257–261CrossRef

12.

Beltran-Corbellini A, Chico-Garcia JL, Martinez-Poles J et al (2020) Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study. Eur J Neurol 27:1738–1741CrossRef

13.

Carignan A, Valiquette L, Grenier C et al (2020) Anosmia and dysgeusia associated with SARS-CoV-2 infection: an age-matched case-control study. CMAJ 192:E702–E707CrossRef

14.

Levinson R, Elbaz M, Ben-Ami R et al (2020) Time course of anosmia and dysgeusia in patients with mild SARS-CoV-2 infection. Infect Dis (Lond) 52:600–602CrossRef

15.

Vaira LA, Salzano G, Deiana G, De Riu G (2020) Anosmia and ageusia: common findings in COVID-19 patients. Laryngoscope 130:1787CrossRef

16.

Haehner A, Draf J, Drager S et al (2020) Predictive value of sudden olfactory loss in the diagnosis of COVID-19. ORL J Otorhinolaryngol Relat Spec 82:175–180CrossRef

17.

Dell’Era V, Farri F, Garzaro G et al (2020) Smell and taste disorders during COVID-19 outbreak: cross-sectional study on 355 patients. Head Neck 42:1591–1596CrossRef

18.

Speth MM, Singer-Cornelius T, Oberle M et al (2020) Olfactory dysfunction and sinonasal symptomatology in COVID-19: prevalence, severity, timing, and associated characteristics. Otolaryngol Head Neck Surg 163(1):114–120. https://doi.org/10.1177/0194599820929185. Epub 2020 May 19. PMID: 32423357; PMCID: PMC7240313

19.

Vaira LA, Hopkins C, Salzano G et al (2020) Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study. Head Neck 42:1560–1569CrossRef

20.

Haehner A, Draf J, Dräger S et al (2020) Predictive value of sudden olfactory loss in the diagnosis of COVID-19. ORL J Otorhinolaryngol Relat Spec 82(4):175–180. https://doi.org/10.1159/000509143. Epub 2020 Jun 11. PMID: 32526759; PMCID: PMC7360503

21.

Han X, Cao Y, Jiang N et al (2020) Novel coronavirus disease 2019 (COVID-19) pneumonia progression course in 17 discharged patients: comparison of clinical and thin-section computed tomography features during recovery. Clin Infect Dis 71:723–731CrossRef

22.

Ye Z, Zhang Y, Wang Y et al (2020) Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. Eur Radiol 30:4381–4389CrossRef

23.

Wang L, He W, Yu X et al (2020) Coronavirus disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up. J Infect 80:639–645CrossRef

24.

Francone M, Iafrate F, Masci GM et al (2020) Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis. Eur Radiol 30:6808–6817CrossRef

25.

Xiang JWJ, Yuan X et al (2020) Potential biochemical markers to identify severe cases among COVID-19 patients. medRxiv (epub ahead of print)

26.

Huang C, Wang Y, Li X et al (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China Lancet 395:497–506CrossRef

27.

Sanli DET, Altundag A, Kandemirli SG et al (2021) Relationship between disease severity and serum IL-6 levels in COVID-19 anosmia. Am J Otolaryngol 42:102796

28.

Chen XLJ, Mo P et al (2020) Restoration of leukomonocyte counts is associated with viral clearance in COVID-19 hospitalized patients. medRxiv (Preprint)

29.

Foster KJ, Jauregui E, Tajudeen B et al (2020) Smell loss is a prognostic factor for lower severity of coronavirus disease 2019. Ann Allergy Asthma Immunol 125:481–483CrossRef

30.

Huang YLX, Li D, Wang L et al (2020) A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19. PLoS One 15(11): e0242045

31.

Zheng YY, Ma YT, Zhang JY, Xie X (2020) COVID-19 and the cardiovascular system. Nat Rev Cardiol 17:259–260CrossRef

32.

Lippi G, Lavie CJ, Sanchis-Gomar F (2020) Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): evidence from a meta-analysis. Prog Cardiovasc Dis 63:390–391CrossRef

Titel: Correlation of olfactory dysfunction with lung involvement and severity of COVID-19
verfasst von: Ali R. Yağmur
Şeyda Akbal Çufalı
Adalet Aypak
Murathan Köksal
Yasin C. Güneş
Kürşat M. Özcan
Publikationsdatum: 10.08.2021
Verlag: Springer International Publishing
Schlagwort: COVID-19
Erschienen in: Irish Journal of Medical Science (1971 -) / Ausgabe 4/2022
Print ISSN: 0021-1265
Elektronische ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-021-02732-x

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Abstract

Background

Aims

Methods

Results

Conclusions

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