As for COVID-19 vaccine, the most frequent concern from families is on the safeness for children aged 5–11 years [
3]. While COVID-19 vaccines were developed rapidly, all steps were taken to make sure they are safe and effectivive for children. During the development of COVID-19 vaccines, phases overlapped to speed up the process, but all phases were completed as required for a clinical trial. COVID-19 vaccine for children ages 5 through 11 years were developed and tested in the same way as adult COVID-19 vaccines. In clinical trial, vaccine side effects were examined and appeared to be mild, similar to those seen with other vaccines recommended in infancy [
4]. Data produced by the industry has been reviewed and analysed by Food and Drug Administration in the United States of America, by European Medicines Agency in Europe and Italian Medicines Agency in our Country. So, actually, the vaccine can be considered safe and effective to the target population who will receive it, namely children aged 5–11 years. To enforce this consideration, over 5 milions of children in the world already got one and in some cases two shots, without safety concerns. Over 7 millions of COVID 19 vaccine shot, just 8 myocarditis have been demonstrated correlated to the immunization. All the children had mild symptoms and promptly recovered. Unlike the mild side effects that some may experience after vaccination, children who got infected with COVID-19 are at risk of getting seriously ill and being hospitalized. From the beginning of COVID-19 pandemic to the 21
st December 2021, in Italy children ages 5 through 11 years have experienced 954.657 COVID-19 cases and 35 deaths from COVID-19. From mid October 2021, a severe increase of cases in 6–11 years old children has been documented, mainly in the latest two weeks. In details, in the period 6–19 December 2021, 59.605 cases have been notifed in children 5–11 years aged, of whom 215 required hospital admission and 4 intensive unit care [
5].