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07.02.2020 | COVID-19 | Review Article Zur Zeit gratis

Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement

verfasst von: Kunling Shen, Yonghong Yang, Tianyou Wang, Dongchi Zhao, Yi Jiang, Runming Jin, Yuejie Zheng, Baoping Xu, Zhengde Xie, Likai Lin, Yunxiao Shang, Xiaoxia Lu, Sainan Shu, Yan Bai, Jikui Deng, Min Lu, Leping Ye, Xuefeng Wang, Yongyan Wang, Liwei Gao, China National Clinical Research Center for Respiratory Diseases, National Center for Children’s Health, Beijing, China, Group of Respirology, Chinese Pediatric Society, Chinese Medical Association, Chinese Medical Doctor Association Committee on Respirology Pediatrics, China Medicine Education Association Committee on Pediatrics, Chinese Research Hospital Association Committee on Pediatrics, Chinese Non-government Medical Institutions Association Committee on Pediatrics, China Association of Traditional Chinese Medicine, Committee on Children’s Health and Medicine Research, China News of Drug Information Association, Committee on Children’s Safety Medication, Global Pediatric Pulmonology Alliance

Erschienen in: World Journal of Pediatrics | Ausgabe 3/2020

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Abstract

Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City, China, by January 30, 2020, a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China. Among the confirmed cases, 1527 were severe cases, 171 had recovered and been discharged at home, and 213 died. And among these cases, a total of 28 children aged from 1 month to 17 years have been reported in China. For standardizing prevention and management of 2019-nCoV infections in children, we called up an experts’ committee to formulate this experts’ consensus statement. This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections. The present consensus statement summarizes current strategies on diagnosis, treatment, and prevention of 2019-nCoV infection in children.

National Health Commission of People’s Republic of China. https://www.nhc.gov.cn/xcs/yqfkdt/202001/a53e6df293cc4ff0b5a16ddf7b6b2b31.shtml. Access 20 Jan 2020.

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020. https://doi.org/10.1056/NEJMoa2001017.CrossRefPubMedPubMedCentral

National Health Commission of People’s Republic of China. Diagnosis and treatment of pneumonia caused by novel coronavirus (trial version 4). https://www.nhc.gov.cn/xcs/zhengcwj/202001/4294563ed35b43209b31739bd0785e67/files/7a9309111267475a99d4306962c8bf78.pdf. Access 28 Jan 2020.

The Society of Pediatrics of Hubei Medical Association, The Society of Pediatrics of Wuhan Medical Association, Hubei Pediatric Medical Quality Control Center. Suggestions on the diagnosis and treatment of novel coronavirus infection in children in Hubei province (trial version 1). CJCP. 2020;22:96–9 (in Chinese).

Chan JF, Yuan S, Kok KH, Wang KK, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person to-person transmission: a study of a family cluster. Lancet. 2020. https://doi.org/10.1016/S0140-6736(20)30154-9.CrossRefPubMedPubMedCentral

Huang CL, Wang YM, Li XW, Ren LL, Zhao JP, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan China. Lancet. 2020. https://doi.org/10.1016/S0140-6736(20)30183-5.CrossRefPubMedPubMedCentral

Chen NS, Zhou M, Dong X, Qu JM, Gong FY, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020. https://doi.org/10.1016/S0140-6736(20)30211-7.CrossRefPubMedPubMedCentral

Li ZZ, Shen KL, Wei XM, Wang HL, Lu J, Tian H, et al. Clinical analysis of pediatric SARS cases in Beijing. Chin J Pediatr. 2003;41:574–7 (in Chinese).

Yang YH. Concern for severe acute respiratory syndrom. Chin J Pediatr. 2003;41:401–2 (in Chinese).

10.

Zeng QY, Liu L, Zeng HS, Yu MH, Ye QC, Deng L, et al. Clinical characteristics and prognosis of 33 children with severe acute respiratory syndrome in Guangzhou area. Chin J Pediatr. 2003;41:408 (in Chinese).

11.

Thabet F, Chehab M, Bafaqih H, Al MS. Middle East respiratory syndrome coronavirus in children. Saudi Med J. 2015;36:484–6.CrossRefPubMedPubMedCentral

12.

National Health Commission of People's Republic of China. Code for the diagnosis and treatment of community-acquired pneumonia in children (2019 edition). https://www.nhc.gov.cn/yzygj/s7653/201902/bfa758ad6add48a599bc74b588a6e89a.shtml. Access 11 Feb 2019.

13.

The Subspecialty Group of Respiratory Diseases of The Society of Pediatrics of Chinese Medical Association. Guidelines for management of community acquired pneumonia in children. Chin J Pediatr. 2013;51:145–52 (in Chinese).

14.

Harris M, Clark J, Coote N, Fletcher P, Harnden A, McKean M, et al. British Thoracic Society guidelines for the management of community acquired pneumonia in children: update 2011. Thorax. 2011;66:1–23.CrossRef

15.

Bradley JS, Byington CL, Shah SS, Alverson B, Carter ER, Harrison C, et al. The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infect Dis. 2011;53:e25–76.CrossRefPubMed

16.

Wang BX, Fish EN. Global virus outbreaks: interferons as 1st responders. Semin Immunol. 2019;43:101300.CrossRefPubMedPubMedCentral

17.

Al-Tawfiq JA, Momattin H, Dib J, Memish ZA. Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study. Int J Infect Dis. 2014;20:42–6.CrossRefPubMedPubMedCentral

18.

Wang HQ, Ma LL, Jiang JD, Pang R, Chen YJ, Li YH. Recombinant human interferon alpha 2b broad-spectrum anti-respiratory viruses pharmacodynamics study in vitro. Acta Pharmaceu Sin. 2014;49:1547–53 (in Chinese).

19.

Hijano DR, Siefker DT, Shrestha B, Jaligama S. Type I interferon potentiates IgA immunity to respiratory syncytial virus infection during infancy. Sci Rep. 2018;8:11034.CrossRefPubMedPubMedCentral

20.

Shen KL, Shang YX, Zhang GC, Xu BP, Fu Z, Cao L, et al. Expert consensus on rational application of interferon α in pediatrics. Chin J Appl Clin Pediatr. 2018;33:1301–8 (in Chinese).

21.

The Expert Committee on Pediatric Medicine of National Healthand Commission, National Health and Family Planning, Commission of The People’s Republic of China, Pediatric Section of Chinese Medical Association Respiratory Group, Respiratory Disease Pediatric Society of Chinese Physicians’ Association, Committee of Pediatric Chinese Medicine Education Association. Guidelines for rational drug use in children with wheezing disorders. Chin J Appl Clin Pediatr. 2018;33:1460–72 (in Chinese).

22.

Liu B, Shang YX, Lu YD. Study on the safety of recombinant human interferon 2b injection (pseudomonas) and hydroxyethyl starch 40 as excipient in SD rats. Int J Pediatr. 2019;46:692–7 (in Chinese).

23.

National Health Commission of People's Republic of China. Guidelines on the diagnosis and treatment of hand, foot and mouth disease (2018 edition). https://www.nhc.gov.cn/yzygj/s3594q/201805/5db274d8697a41ea84e88eedd8bf8f63.shtml. Access 28 Jun 2018.

24.

Xu YL, Li Y, Chen YP, Xin SX, Xie L, Liang YD, et al. A multicenter controlled clinical study on the efficacy and safety of recombinant human interferon α2b spray in the treatment of hand, foot and mouth disease in children. Chin J Infect. 2018;36:101–6 (in Chinese).

25.

Infection group of pediatric branch of Chinese Medical Association, National Center for Medical Quality Control of Infectious Diseases. Expert consensus on diagnosis and treatment of herpetic pharyngitis (2019 edition). Chin J Pediatr. 2019;57:177–80 (in Chinese).

26.

Shen KL, Shang YX, Zhang H. A multicenter, randomized, controlled clinical study on the efficacy and safety of recombinant human interferon 2b spray (pseudomonas) in the treatment of acute upper respiratory tract infection in children. Chin J Appl Clin Pediatr. 2019;34:1010–6 (in Chinese).

27.

Gao H, Zhang LL, Wei Q, Duan ZJ, Tu XM, Yu ZA, et al. Preventive and therapeutic effects of recombinant IFN -α2b nasal spray on SARS-CoV infection in Macaca mulata. Chin J Exp Clin Virol. 2005;19:207–11 (in Chinese).

28.

Yu DX, Chen Q, Zhang LL, Liu Y, Yu ZA, Li ZF, et al. A field trial of recombinant human interferon α-2b for nasal spray to prevent SARS and other respiratory viral infections. Chin J Exp Clin Virol. 2005;19:216–9 (in Chinese).

29.

Chu CM. Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings. Thorax. 2004;59:252–6.CrossRefPubMedPubMedCentral

30.

AbbVie Deutschland GmbH & Co.KG. Lopinar veletonavir tablet specification. https://www.jianke.com/product/79823.html. Access 7 July 2017.

31.

Ji XG, Zhao YH, Zhang M, Zhao JH, Wang JY, et al. The Experimental Study of the Anti-SARS-CoV Effect of Arbidole. Pharm J Chin PLA. 2004;20:274–6 (in Chinese).

32.

National Health Commission of People's Republic of China. Influenza diagnosis and treatment protocol (revised edition 2019). https://wenku.baidu.com/view/00f0d41d2079168884868762caaedd3383c4b57f.html. Access 30 Nov 2019.

33.

World Health Organization. Home care for patients with suspected novel coronavirus (nCoV) infection presenting with mild symptoms and management of contacts. https://www.who.int/internal-publications-detail/home-care-for-patients-with-suspected-novel-coronavirus-(nCoV)-infection-presenting-with-mild-symptoms-and-management-of-contacts. Access 20 Jan 2020.

34.

The US Centers for Disease Control and Prevention. Interim Guidance for Preventing 2019 Novel Coronavirus (2019-nCoV) from Spreading to Others in Homes and Communities. https://www.cdc.gov/coronavirus/2019-ncov/guidance-prevent-spread-chinese.html. Access 20 Jan 2020.

35.

National Health Commission of People's Republic of China. Guidelines for transmission and prevention of novel coronaviruses. https://www.nhc.gov.cn/xcs/kpzs/202001/9e73060017d744aeafff8834fc0389f4.shtml. Access 27 Jan 2020.

Titel: Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement
verfasst von: Kunling Shen
Yonghong Yang
Tianyou Wang
Dongchi Zhao
Yi Jiang
Runming Jin
Yuejie Zheng
Baoping Xu
Zhengde Xie
Likai Lin
Yunxiao Shang
Xiaoxia Lu
Sainan Shu
Yan Bai
Jikui Deng
Min Lu
Leping Ye
Xuefeng Wang
Yongyan Wang
Liwei Gao
China National Clinical Research Center for Respiratory Diseases
National Center for Children’s Health, Beijing, China
Group of Respirology, Chinese Pediatric Society, Chinese Medical Association
Chinese Medical Doctor Association Committee on Respirology Pediatrics
China Medicine Education Association Committee on Pediatrics
Chinese Research Hospital Association Committee on Pediatrics
Chinese Non-government Medical Institutions Association Committee on Pediatrics
China Association of Traditional Chinese Medicine, Committee on Children’s Health and Medicine Research
China News of Drug Information Association, Committee on Children’s Safety Medication
Global Pediatric Pulmonology Alliance
Publikationsdatum: 07.02.2020
Verlag: Springer Singapore
Schlagwörter: COVID-19
Pädiatrische Diagnostik
Erschienen in: World Journal of Pediatrics / Ausgabe 3/2020
Print ISSN: 1708-8569
Elektronische ISSN: 1867-0687
DOI: https://doi.org/10.1007/s12519-020-00343-7

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Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement

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