Skip to main content
Erschienen in: European Archives of Oto-Rhino-Laryngology 8/2020

06.04.2020 | COVID-19 | Rhinology Zur Zeit gratis

Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

verfasst von: Jerome R. Lechien, Carlos M. Chiesa-Estomba, Daniele R. De Siati, Mihaela Horoi, Serge D. Le Bon, Alexandra Rodriguez, Didier Dequanter, Serge Blecic, Fahd El Afia, Lea Distinguin, Younes Chekkoury-Idrissi, Stéphane Hans, Irene Lopez Delgado, Christian Calvo-Henriquez, Philippe Lavigne, Chiara Falanga, Maria Rosaria Barillari, Giovanni Cammaroto, Mohamad Khalife, Pierre Leich, Christel Souchay, Camelia Rossi, Fabrice Journe, Julien Hsieh, Myriam Edjlali, Robert Carlier, Laurence Ris, Andrea Lovato, Cosimo De Filippis, Frederique Coppee, Nicolas Fakhry, Tareck Ayad, Sven Saussez

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 8/2020

Einloggen, um Zugang zu erhalten

Abstract

Objective

To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection.

Methods

Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. Patients completed olfactory and gustatory questionnaires based on the smell and taste component of the National Health and Nutrition Examination Survey, and the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS).

Results

A total of 417 mild-to-moderate COVID-19 patients completed the study (263 females). The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. 85.6% and 88.0% of patients reported olfactory and gustatory dysfunctions, respectively. There was a significant association between both disorders (p < 0.001). Olfactory dysfunction (OD) appeared before the other symptoms in 11.8% of cases. The sQO-NS scores were significantly lower in patients with anosmia compared with normosmic or hyposmic individuals (p = 0.001). Among the 18.2% of patients without nasal obstruction or rhinorrhea, 79.7% were hyposmic or anosmic. The early olfactory recovery rate was 44.0%. Females were significantly more affected by olfactory and gustatory dysfunctions than males (p = 0.001).

Conclusion

Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients, who may not have nasal symptoms. The sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
6.
Zurück zum Zitat Suzuki M, Saito K, Min WP, Vladau C, Toida K, Itoh H, Murakami S (2007) Identification of viruses in patients with postviral olfactory dysfunction. Laryngoscope 117(2):272–277CrossRefPubMedCentralPubMed Suzuki M, Saito K, Min WP, Vladau C, Toida K, Itoh H, Murakami S (2007) Identification of viruses in patients with postviral olfactory dysfunction. Laryngoscope 117(2):272–277CrossRefPubMedCentralPubMed
18.
Zurück zum Zitat Guan W, Ni Z, Hu Y, Liang W, Ou C, He J et al (2020) Clinical characteristics of 2019 novel coronavirus infection in China. Medrxiv Guan W, Ni Z, Hu Y, Liang W, Ou C, He J et al (2020) Clinical characteristics of 2019 novel coronavirus infection in China. Medrxiv
19.
Zurück zum Zitat Benvenuto D, Giovanetti M, Ciccozzi A, Spoto S, Angeletti S, Ciccozzi M (2020) The 2019-new coronavirus epidemic: evidence for virus evolution. J Med Virol 92(4):455–459CrossRefPubMedCentralPubMed Benvenuto D, Giovanetti M, Ciccozzi A, Spoto S, Angeletti S, Ciccozzi M (2020) The 2019-new coronavirus epidemic: evidence for virus evolution. J Med Virol 92(4):455–459CrossRefPubMedCentralPubMed
21.
Zurück zum Zitat Li W, Zhang C, Sui J, Kuhn JH et al (2005) Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J 24(8):1634–1643CrossRefPubMedCentralPubMed Li W, Zhang C, Sui J, Kuhn JH et al (2005) Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J 24(8):1634–1643CrossRefPubMedCentralPubMed
24.
Zurück zum Zitat Hummel T, Whitcroft KL, Andrews P et al (2017) Position paper on olfactory dysfunction. Rhinol Suppl 54(26):1–30CrossRefPubMed Hummel T, Whitcroft KL, Andrews P et al (2017) Position paper on olfactory dysfunction. Rhinol Suppl 54(26):1–30CrossRefPubMed
Metadaten
Titel
Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study
verfasst von
Jerome R. Lechien
Carlos M. Chiesa-Estomba
Daniele R. De Siati
Mihaela Horoi
Serge D. Le Bon
Alexandra Rodriguez
Didier Dequanter
Serge Blecic
Fahd El Afia
Lea Distinguin
Younes Chekkoury-Idrissi
Stéphane Hans
Irene Lopez Delgado
Christian Calvo-Henriquez
Philippe Lavigne
Chiara Falanga
Maria Rosaria Barillari
Giovanni Cammaroto
Mohamad Khalife
Pierre Leich
Christel Souchay
Camelia Rossi
Fabrice Journe
Julien Hsieh
Myriam Edjlali
Robert Carlier
Laurence Ris
Andrea Lovato
Cosimo De Filippis
Frederique Coppee
Nicolas Fakhry
Tareck Ayad
Sven Saussez
Publikationsdatum
06.04.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 8/2020
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-020-05965-1

Weitere Artikel der Ausgabe 8/2020

European Archives of Oto-Rhino-Laryngology 8/2020 Zur Ausgabe

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.