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Indian Journal of Otolaryngology and Head & Neck Surgery

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28.05.2021 | COVID-19 | Original Article Zur Zeit gratis

Smell and Taste Disturbance in COVID-19 Patients: A Prospective Multicenteric Review

verfasst von: Subash Bhatta, Dibya Sharma, Santosh Sharma, Leison Maharjan, Sushma Bhattachan, Mukesh Kumar Shah, Aditya Singhal, Asheesh Dora Ghanpur, Dushyanth Ganesuni, Shraddha Jayant Saindani

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Sonderheft 2/2022

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Abstract

To study the incidence of the smell and taste disturbance in the COVID-19 patients and a follow up at 4 months to observe for the duration of resolution of these symptoms. This is a multicentric prospective study carried out in 3 different countries, from April, 2020 to January, 2021. The COVID-19 positive patients, aged between 15 and 60 years, were inquired about the presence of any smell or taste related symptoms. The same patients were followed up with the telephonic interview after 2 months and then after 4 months, respectively. The duration of resolution of the smell and taste disturbance symptoms was noted. Total of 188 COVID-19 positive patients, average age 33.1 ± 1.7 years, 54.2% males and 45.8% female were included in the study. The smell disturbance was present in 60.6% (hyposmia 36.1%, anosmia 20.2%, and parosmia 4.2%) and taste disturbance in 28.7% of patients (hypogeusia 20.2%, ageusia 6.9%, and parageusia 1.6%). There was improvement of anosmia by 97.4, hyposmia by 95.6%, parosmia by 100%, ageusia by 100%, hypogeusia 94.8%, and parageusia by 66.7%, at 4 months follow up. The present study concludes that the smell and taste disturbances are one of the main early presenting features of the COVID-19 infection. The temporary effect of the COVID-19 infection on the olfactory and gustatory pathway was also highlighted with more than 95% patients improving at 4 months of follow up.

Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC (2020) Pathophysiology, transmission, diagnosis, and treatment of Coronavirus Disease 2019 (COVID-19): a review. JAMA J Am Med Assoc 324:782–793. https://doi.org/10.1001/jama.2020.12839CrossRef

Yuki K, Fujiogi M, Koutsogiannaki S (2020) COVID-19 pathophysiology: a review. Clin Immunol 215:108427. https://doi.org/10.1016/j.clim.2020.108427CrossRefPubMedPubMedCentral

Cucinotta D, Vanelli M (2020) WHO declares COVID-19 a pandemic. Acta Biomed 91:157–160. https://doi.org/10.23750/abm.v91i1.9397.CrossRefPubMedPubMedCentral

Zou X, Chen K, Zou J, Han P, Hao J, Han Z (2020) Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med 14:185–192. https://doi.org/10.1007/s11684-020-0754-0CrossRefPubMedPubMedCentral

Baig AM, Khaleeq A, Ali U, Syeda H (2020) Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 11:995–998. https://doi.org/10.1021/acschemneuro.0c00122CrossRefPubMed

Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M et al (2020) SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med 26:681–687. https://doi.org/10.1038/s41591-020-0868-6CrossRefPubMedPubMedCentral

Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X et al (2020) High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci 12:1–5. https://doi.org/10.1038/s41368-020-0074-xCrossRef

Zhang H, Kang Z, Gong H, Xu D, Wang J, Li Z et al (2020) The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes. BioRxiv 2020:2020.01.30.927806. https://doi.org/10.1101/2020.01.30.927806.

Mizumoto K, Kagaya K, Zarebski A, Chowell G (2020) Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020. Eurosurveillance 25:2000180. https://doi.org/10.2807/1560-7917.ES.2020.25.10.2000180CrossRefPubMedPubMedCentral

10.

Liu K, Chen Y, Lin R, Han K (2020) Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients. J Infect 80:e14–e18. https://doi.org/10.1016/j.jinf.2020.03.005CrossRefPubMedPubMedCentral

11.

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al (2020) Clinical characteristics of 2019 novel coronavirus infection in China. N Engl J Med. https://doi.org/10.1101/2020.02.06.20020974.

12.

Liu K, Fang YY, Deng Y, Liu W, Wang MF, Ma JP et al (2020) Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J (Engl) 133:1025–1031. https://doi.org/10.1097/CM9.0000000000000744CrossRefPubMed

13.

Fang Z, 3# Y, Wu K, Lai K, Sun X, Zhong N et al. Clinical Characteristics of 2019 Coronavirus Pneumonia (COVID-19): an updated systematic review n.d. https://doi.org/10.1101/2020.03.07.20032573.

14.

Hassan SA, Sheikh FN, Jamal S, Ezeh JK, Akhtar A (2020) Coronavirus (COVID-19): a review of clinical features, diagnosis, and treatment. Cureus, 12. https://doi.org/10.7759/cureus.7355.

15.

Bhatta S, Gandhi S, Saindani SJ, Ganesuni D, Ghanpur AD, Otorhinolaryngological Manifestations of Coronavirus Disease (2019) a prospective review of 600 patients. J Laryngol Otol 2021:1–15. https://doi.org/10.1017/S0022215121000220CrossRef

16.

Soler ZM, Patel ZM, Turner JH, Holbrook EH (2020) A primer on viral-associated olfactory loss in the era of COVID-19. Int Forum Allergy Rhinol 10:814–820. https://doi.org/10.1002/alr.22578CrossRefPubMedPubMedCentral

17.

Parma V, Ohla K, Veldhuizen MG, Niv MY, Kelly CE, Bakke AJ et al (2020) More than smell—COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chem Senses 45:609–622. https://doi.org/10.1093/chemse/bjaa041CrossRefPubMed

18.

Dubé M, Le Coupanec A, Wong AHM, Rini JM, Desforges M, Talbot PJ (2018) Axonal transport enables neuron-to-neuron propagation of Human Coronavirus OC43. J Virol, 92. https://doi.org/10.1128/jvi.00404-18.

19.

Desforges M, Le Coupanec A, Dubeau P, Bourgouin A, Lajoie L, Dubé M et al (2019) Human Coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses 12:14. https://doi.org/10.3390/v12010014CrossRefPubMedPubMedCentral

20.

Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Chiesa-Estomba CM, Salzano G et al (2020) Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study. J Laryngol Otol 134:703–709. https://doi.org/10.1017/S0022215120001826CrossRefPubMed

21.

Lechien JR, Hopkins C, Saussez S (2020) Sniffing out the evidence; it’s now time for public health bodies recognize the link between COVID-19 and smell and taste disturbance. Rhinology 58:1–2. https://doi.org/10.4193/Rhin20.159CrossRef

22.

Coelho DH, Kons ZA, Costanzo RM, Reiter ER (2020) Subjective changes in smell and taste during the COVID-19 pandemic: a National Survey—Preliminary Results. Otolaryngol Head Neck Surg (United States) 163:302–306. https://doi.org/10.1177/0194599820929957CrossRef

23.

Moein ST, Hashemian SMR, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL (2020) Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol 10:944–950. https://doi.org/10.1002/alr.22587CrossRefPubMedPubMedCentral

24.

Kerr C, Hughes G, McKenna L, Bergin C (2020) Prevalence of smell and taste dysfunction in a cohort of CoVID19 outpatients managed through remote consultation from a large urban teaching hospital in Dublin. Ireland Infect Prev Pract 2:100076. https://doi.org/10.1016/j.infpip.2020.100076CrossRefPubMed

25.

Roland LT, Gurrola JG, Loftus PA, Cheung SW, Chang JL (2020) Smell and taste symptom-based predictive model for COVID-19 diagnosis. Int Forum Allergy Rhinol 10:832–838. https://doi.org/10.1002/alr.22602CrossRefPubMedPubMedCentral

26.

Izquierdo-Domínguez A, Rojas-Lechuga MJ, Chiesa-Estomba C, Calvo-Henríquez C, Ninchritz-Becerra E, Soriano-Reixach M et al (2020) Smell and taste dysfunction in covid-19 is associated with younger age in ambulatory settings: a multicenter cross-sectional study. J Investig Allergol Clin Immunol 30:346–357. https://doi.org/10.18176/jiaci.0595.CrossRefPubMed

27.

Mazzatenta A, Neri G, D’Ardes D, De Luca C, Marinari S, Porreca E et al (2020) Smell and taste in severe CoViD-19: self-reported vs. testing. Front Med 7:589409. https://doi.org/10.3389/fmed.2020.589409.

28.

Sayin İ, Yaşar KK, Yazici ZM (2020) Taste and smell impairment in COVID-19: An AAO-HNS anosmia reporting tool-based comparative study. Otolaryngol Head Neck Surg (United States) 163:473–479. https://doi.org/10.1177/0194599820931820CrossRef

29.

Bhattacharyya N, Kepnes LJ (2015) Contemporary assessment of the prevalence of smell and taste problems in adults. Laryngoscope 125:1102–1106. https://doi.org/10.1002/lary.24999CrossRefPubMed

30.

Hoffman HJ, Ishii EK, Macturk RH (1998) Age-related changes in the prevalence of smell/taste problems among the United States Adult Population: results of the 1994 disability supplement to the National Health Interview Survey (NHIS). Ann N Y Acad Sci 855:716–722. https://doi.org/10.1111/j.1749-6632.1998.tb10650.xCrossRefPubMed

31.

Schiffman SS (1997) Taste and smell losses in normal aging and disease. JAMA J Am Med Assoc 278:1357. https://doi.org/10.1001/jama.1997.03550160077042CrossRef

32.

Lafreniere D, Mann N (2009) Anosmia: loss of smell in the elderly. Otolaryngol Clin North Am 42:123–131. https://doi.org/10.1016/j.otc.2008.09.001CrossRefPubMed

33.

Cazzolla AP, Lovero R, Lo Muzio L, Testa NF, Schirinzi A, Palmieri G et al (2020) Taste and smell disorders in COVID-19 patients: role of interleukin-6. ACS Chem Neurosci 11:2774–2781. https://doi.org/10.1021/acschemneuro.0c00447CrossRefPubMed

34.

Prescott J (2011) Multimodal chemosensory interactions and perception of flavor. Neural bases multisensory process. CRC Press, Boca Raton, pp 703–716. https://doi.org/10.1201/b11092-45.

35.

Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF et al (1991) Smell and taste disorders, a study of 750 patients From the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Neck Surg 117:519–528. https://doi.org/10.1001/archotol.1991.01870170065015CrossRef

36.

Witt M, Miller IJ (1992) Comparative lectin histochemistry on taste buds in foliate, circumvallate and fungiform papillae of the rabbit tongue. Histochemistry 98:173–182. https://doi.org/10.1007/BF00315876CrossRefPubMed

37.

Pushpass R-AG, Pellicciotta N, Kelly C, Proctor G, Carpenter GH (2019) Reduced salivary mucin binding and glycosylation in older adults influences taste in an in vitro cell model. Nutrients 11:2280. https://doi.org/10.3390/nu11102280.

38.

Vaira LA, Salzano G, Fois AG, Piombino P, De Riu G (2020) Potential pathogenesis of ageusia and anosmia in COVID-19 patients. Int Forum Allergy Rhinol 10:1103–1104. https://doi.org/10.1002/alr.22593CrossRefPubMedPubMedCentral

39.

Lee Y, Min P, Lee S, Kim SW (2020) Prevalence and duration of acute loss of smell or taste in COVID-19 patients. J Korean Med Sci, 35. https://doi.org/10.3346/JKMS.2020.35.E174.

40.

Kaye R, Chang CWD, Kazahaya K, Brereton J, Denneny JC (2020) COVID-19 Anosmia reporting tool: initial findings. Otolaryngol Head Neck Surg (United States) 163:132–134. https://doi.org/10.1177/0194599820922992CrossRef

41.

Vaira LA, Deiana G, Salzano FA (2020) Functional endoscopic surgery after facial trauma view project Chemosensitive dysfunctions in COVID-19 patients View project 2020. https://doi.org/10.1002/lary.28837.

42.

Hopkins C, Surda P, Whitehead E, Nirmal Kumar B. Early recovery following new onset anosmia during the COVID-19 pandemic-an observational cohort study n.d. https://doi.org/10.1186/s40463-020-00423-8.

43.

Pierron D, Pereda-Loth V, Mantel M, Moranges M, Bignon E, Alva O et al (2020) Smell and taste changes are early indicators of the COVID-19 pandemic and political decision effectiveness. Nat Commun 11:1–8. https://doi.org/10.1038/s41467-020-18963-yCrossRef

Titel: Smell and Taste Disturbance in COVID-19 Patients: A Prospective Multicenteric Review
verfasst von: Subash Bhatta
Dibya Sharma
Santosh Sharma
Leison Maharjan
Sushma Bhattachan
Mukesh Kumar Shah
Aditya Singhal
Asheesh Dora Ghanpur
Dushyanth Ganesuni
Shraddha Jayant Saindani
Publikationsdatum: 28.05.2021
Verlag: Springer India
Schlagwort: COVID-19
Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe Sonderheft 2/2022
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-021-02664-z

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Smell and Taste Disturbance in COVID-19 Patients: A Prospective Multicenteric Review

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