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Inflammopharmacology

Erschienen in:

30.05.2022 | COVID-19 | Review

The key role of Calpain in COVID-19 as a therapeutic strategy

verfasst von: Aref Doozandeh Juibari, Mohammad Hossein Rezadoost, Masoud Soleimani

Erschienen in: Inflammopharmacology | Ausgabe 5/2022

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Abstract

COVID-19 is one of the viral diseases that has caused many deaths and financial losses to humans. Using the available information, this virus appears to activate the host cell-death mechanism through Calpain activation. Calpain inhibition can stop its downstream cascade reactions that cause cell death. Given the main roles of Calpain in the entry and pathogenicity of the SARS-CoV-2, its inhibition can be effective in controlling the COVID-19. This review describes how the virus activates Calpain by altering calcium flow. When Calpain was activated, the virus can enter the target cell. Subsequently, many complications of the disease, such as inflammation, cytokine storm and pulmonary fibrosis, are caused by virus-activated Calpain function. Calpain inhibitors appear to be a potential drug to control the disease and prevent death from COVID-19.

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Titel: The key role of Calpain in COVID-19 as a therapeutic strategy
verfasst von: Aref Doozandeh Juibari
Mohammad Hossein Rezadoost
Masoud Soleimani
Publikationsdatum: 30.05.2022
Verlag: Springer International Publishing
Schlagwort: COVID-19
Erschienen in: Inflammopharmacology / Ausgabe 5/2022
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-022-01002-1

Springer Medizin

Abstract

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