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Erschienen in: Clinical Rheumatology 9/2019

29.04.2019 | Original Article

Cross-cultural adaptation of the connective tissue disease screening questionnaire and development of a Chinese version in a multi-ethnic Asian population

verfasst von: Ling Xiang, Edmund Pek Siang Teo, Andrea Hsiu Ling Low, Ying Ying Leung, Warren Fong, Xiaohui Xin, Mihir Gandhi, Yu Heng Kwan, Elenore J. B. Uy, Jeffrey Andrew Sparks, Elizabeth W. Karlson, Julian Thumboo

Erschienen in: Clinical Rheumatology | Ausgabe 9/2019

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Abstract

Objectives

To cross-culturally adapt the Connective Tissue Disease (CTD) Screening Questionnaire (CSQ) in a multi-ethnic Asian population in Singapore.

Methods

An expert panel of accredited rheumatologists evaluated the content validity of the original CSQ. Consenting participants newly referred from primary care to a rheumatology specialist outpatient clinic for evaluation of possible CTDs were studied. Cognitive debriefing interviews (CDIs) using the original CSQ were conducted with English-speaking participants, with modifications made based on their inputs and in discussion with a second expert panel (rheumatologists and the CSQ developers). Forward and back translations of the adapted English version were reviewed by the second expert panel. The common translation produced was tested in CDIs with Chinese-speaking participants. Adapted English and Chinese versions were pilot tested in a separate group of newly referred patients.

Results

Content validity of the original CSQ was confirmed by the expert panel. A total of 30 and 15 participants were recruited for English and Chinese CDIs, respectively. Alternative terms and explanatory notes were added to difficult medical terms in the adapted English CSQ. A further explanatory note was added to one difficult item, and English medical terms were retained in the Chinese version. Pilot testing of the adapted CSQ was performed on 116 participants, which exhibited an overall sensitivity and specificity of 71% and 58%, respectively, in identifying CTDs.

Conclusions

The adapted CSQ demonstrated satisfactory sensitivity in the pilot testing and appears to be a promising tool for facilitating early identification of CTDs in the multi-ethnic Asian population.

Key Points

• Early identification and management of patients with CTDs is crucial given their high disease burden and short “windows of opportunity.”
• High reliability and validity of original CSQ and its cross-culturally adapted versions have been reported; however, the CSQ has not been validated in Southeast Asia where CTDs are associated with higher morbidity and mortality compared to other countries.
• Our cross-culturally adapted CSQ demonstrated satisfactory sensitivity in identifying CTDs in the multi-ethnic Asian population.
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Metadaten
Titel
Cross-cultural adaptation of the connective tissue disease screening questionnaire and development of a Chinese version in a multi-ethnic Asian population
verfasst von
Ling Xiang
Edmund Pek Siang Teo
Andrea Hsiu Ling Low
Ying Ying Leung
Warren Fong
Xiaohui Xin
Mihir Gandhi
Yu Heng Kwan
Elenore J. B. Uy
Jeffrey Andrew Sparks
Elizabeth W. Karlson
Julian Thumboo
Publikationsdatum
29.04.2019
Verlag
Springer London
Erschienen in
Clinical Rheumatology / Ausgabe 9/2019
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-019-04567-5

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