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01.05.2015 | Nephrology - Original Paper

CT-based renal volume and graft function after living-donor kidney transplantation: Is there a volume threshold to avoid?

verfasst von: Jorge Dias, Jorge Malheiro, Manuela Almeida, Leonídio Dias, Miguel Silva-Ramos, La Salete Martins, Luís Xambre, António Castro-Henriques

Erschienen in: International Urology and Nephrology | Ausgabe 5/2015

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Abstract

Purpose

Donated kidney volume influences post-transplant outcomes and graft survival. We evaluated the relationship between living-donor kidney volume and recipient graft function at 12 months post-transplantation, exploring a volume threshold for a suboptimal graft function, and compared two different formulas of volume estimation.

Methods

A retrospective analysis of 82 pairs of living-donor kidney transplants was conducted. Donor renal volumes were estimated from computerized tomography scans using the ellipsoid formula and the voxel counting technique. Linear and restricted cubic regression spline was used to analyze the association of volume with graft function. Additionally, we determined the correlation between the two volume estimation formulas and established a correction factor for the ellipsoid formula.

Results

Renal volume (adjusted to recipient BSA) had the strongest independent effect (B = 1.65 per 10 ml/m² increase, p value <0.001) on graft function at 12 months. The eGFR at 12 months was 52.5, 63.6 and 67.6 ml/min/1.73 m² for the low, medium and high volume ratio terciles, respectively (p value <0.001). The odds of a GFR <50 ml/min became significantly reduced with volumes above 145 cc/1.73 m². A strong positive correlation between the two formulas was identified (R ² = 0.705), but the optimal correction factor for our cohort was 0.566.

Conclusions

In a Caucasian population, higher donor kidney volumes estimated from preoperative CT scans are associated with higher recipient eGFRs at 12 months after live-donor transplantation. Using this criterion, transplant teams can potentially improve selection of living donors if multiple donors are available. However, the need for precise estimation of donor kidney volumes should not be overlooked.

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Titel: CT-based renal volume and graft function after living-donor kidney transplantation: Is there a volume threshold to avoid?
verfasst von: Jorge Dias
Jorge Malheiro
Manuela Almeida
Leonídio Dias
Miguel Silva-Ramos
La Salete Martins
Luís Xambre
António Castro-Henriques
Publikationsdatum: 01.05.2015
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 5/2015
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-015-0959-3

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CT-based renal volume and graft function after living-donor kidney transplantation: Is there a volume threshold to avoid?