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Current Oncology Reports
Erschienen in: Current Oncology Reports 5/2018

01.05.2018 | Genitourinary Cancers (DP Petrylak and JW Kim, Section Editors)

Current and Emerging Therapeutic Targets for Metastatic Renal Cell Carcinoma

verfasst von: Kevin Zarrabi, Shenhong Wu

Erschienen in: Current Oncology Reports | Ausgabe 5/2018

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Abstract

Purpose of review

The treatment of advanced renal cell carcinoma has evolved dramatically over recent years. In this review, we will summarize current and emerging therapies based on molecular targets and provide insight into treatment strategy for metastatic renal cell carcinoma.

Recent findings

We have witnessed a paradigm shift in the therapeutic landscape as treatment was formerly reliant on cytokine-based agents which have now been replaced with therapies targeting angiogenesis, mammalian target of rapamycin pathways, and immune responses. These dramatic changes are primarily due to our improved understanding of the underlying mutations and molecular mechanisms leading to tumorigenesis and progression.

Summary

We now have targeted agents in the form of small-molecule tyrosine kinase inhibitors, monoclonal antibodies, and mTOR inhibitors. Moreover, immunotherapy-targeting checkpoints of T-lymphocyte activity has provided increased overall survival and a new class of agents with potential to radically change the treatment options. With these agents and their combination, durable responses are increasingly seen even though treatment resistance remains a huge challenge. New treatment strategies are rapidly developing and the therapeutic landscape is expected for further evolution.
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Metadaten
Titel
Current and Emerging Therapeutic Targets for Metastatic Renal Cell Carcinoma
verfasst von
Kevin Zarrabi
Shenhong Wu
Publikationsdatum
01.05.2018
Verlag
Springer US
Erschienen in
Current Oncology Reports / Ausgabe 5/2018
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-018-0684-z

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