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Acta Neurochirurgica

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01.02.2010 | Case Report

Cystic craniopharyngioma: trans-sphenoidal surgery and intra-cystic apposition of “bleomycin wax”

verfasst von: Mario Francesco Fraioli, Laura Moschettoni, Elisabetta Catena, Chiara Fraioli

Erschienen in: Acta Neurochirurgica | Ausgabe 2/2010

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Summary

Background

The current therapeutic approach to craniopharyngioma is multidisciplinary. Sub-total removal, followed by adjuvant treatments, especially in large cystic tumours, is an accepted regime reported by many authors.

Case report

A young patient with an intra- and suprasellar cystic craniopharyngioma was operated on via a microsurgical trans-sphenoidal approach, achieving sub-total removal and bleomycin mixed with bone wax (“bleomycin wax”) applied to the capsular remnant.

Results

Pre-operative neurological and endocrinological deficit improved after surgery. There was no evidence of tumour recurrence after a follow-up period of 5.4 years.

Conclusions

The intra-operative use of “bleomycin-wax” should be limited to those patients in whom intra-operative CSF fistula does not occur.

Aho CJ, Liu C, Zelman V, Couldwell WT, Weiss MH (2005) Surgical outcomes in 118 patients with Rathke cleft cysts. J Neurosurg 102(2):189–193CrossRefPubMed

Alén JF, Boto GR, Lagares A, de la Lama A, Gómez PA, Lobato RD (2002) Intra-tumoural bleomycin as a treatment for recurrent cystic craniopharyngioma. Case report and review of the literature. Neurocirugia (Astur) 13(6):479–485

Amendola BE, Wolf A, Coy SR, Amendola MA (2003) Role of radiosurgery in craniopharyngiomas: a preliminary report. Med Pediatr Oncol 41(2):123–127. doi:10.1002/mpo.10364 CrossRefPubMed

Belen D, Er U, Yigitkanli K, Bolay H (2007) Delayed neurotoxic complication of intra-cavitary bleomycin therapy for craniopharyngioma in a child who had previously undergone radiosurgery. Case report. J Neurosurg 106(5 Suppl):391–393PubMed

Cáceres A (2005) Intra-cavitary therapeutic options in the management of cystic craniopharyngioma. Childs Nerv Syst 21(8–9):705–718. doi:10.1007/s00381-005-1227-0 CrossRefPubMed

Fraioli MF, Santoni R, Fraioli C, Contratti F (2006) “Conservative” surgical approach and early post-operative radiotherapy in a patient with a huge cystic craniopharyngioma. Childs Nerv Syst 22(2):151–163. doi:10.1007/s00381-005-1191-8 CrossRefPubMed

Gupta DK, Ojha BK, Sarkar C, Mahapatra AK, Sharma BS, Mehta VS (2006) Recurrence in paediatric craniopharyngiomas: analysis of clinical and histological features. Childs Nerv Syst 22(1):50–55. doi:10.1007/s00381-005-1171-z CrossRefPubMed

Haisa T, Ueki K, Yoshida S (1994) Toxic effects of bleomycin on the hypothalamus following its administration into a cystic craniopharyngioma. Br J Neurosurg 8:747–750. doi:10.3109/02688699409101192 CrossRefPubMed

Hargrave DR (2006) Does chemotherapy have a role in the management of craniopharyngioma? J Pediatr Endocrinol Metab 19(Suppl 1):407–412PubMed

10.

Hukin J, Steinbok P, Lafay-Cousin L, Hendson G, Strother D, Mercier C, Samson Y, Howes W, Bouffet E (2007) Intra-cystic bleomycin therapy for craniopharyngioma in children: the Canadian experience. Cancer 109(10):2124–2131CrossRefPubMed

11.

Jiang R, Liu Z, Jhu C (2002) Preliminary exploration of the clinical effect of bleomycin on craniopharyngiomas. Stereotact Funct Neurosurg 78:84–94. doi:10.1159/000068014 CrossRefPubMed

12.

Jane JR JA, Laws JR ER, Jagannathan J, Dumont AS (2005) Paediatric sellar tumours: diagnostic procedures and management. Neurosurg Focus 18(6A):E6

13.

Julow J, Backlund EO, Lányi F, Hajda M, Bálint K, Nyáry I, Szeifert GT (2007) Long-term results and late complications after intra-cavitary yttrium-90 colloid irradiation of recurrent cystic craniopharyngiomas. Neurosurgery 61(2):288–296. doi:10.1227/01.NEU.0000255528.68963.EF CrossRefPubMed

14.

Kalapurakal JA (2005) Radiation therapy in the management of paediatric craniopharyngiomas—a review. Childs Nerv Syst 21(8–9):808–816. doi:10.1007/s00381-005-1188-3 CrossRefPubMed

15.

Kobayashi T (2007) Treatment strategy and pathological background of radiosurgery for craniopharyngiomas. Prog Neurol Surg 20:180–191. doi:10.1159/000100113 CrossRefPubMed

16.

Mottolese C, Stan H, Hermier M, Berlier P, Convert J, Frappaz D, Lapras C (2001) Intra-cystic chemotherapy with bleomycin in the treatment of craniopharyngiomas. Childs Nerv Syst 17:724–730. doi:10.1007/s003810000361 CrossRefPubMed

17.

Savas A, Erdem A, Tun K, Kanpolat Y (2000) Fatal toxic effect of bleomycin on brain tissue after intra-cystic chemotherapy for a craniopharyngioma: case report. Neurosurgery 46(1):213–217. doi:10.1097/00006123-200001000-00043 CrossRefPubMed

18.

Scarzello G, Buzzaccarini MS, Perilongo G, Viscardi E, Faggin R, Carollo C, Calderone M, Franchi A, Sotti G (2006) Acute and late morbidity after limited resection and focal radiation therapy in craniopharyngiomas. J Pediatr Endocrinol Metab 19(Suppl 1):399–405PubMed

19.

Suh JH, Gupta N (2006) Role of radiation therapy and radiosurgery in the management of craniopharyngiomas. Neurosurg Clin N Am 17(2):143–148. doi:10.1016/j.nec.2006.02.001 CrossRefPubMed

20.

Takahashi H, Yamaguchi F, Teramoto A (2005) Long-term outcome and reconsideration of intra-cystic chemotherapy with bleomycin for craniopharyngioma in children. Childs Nerv Syst 21(8–9):701–704. doi:10.1007/s00381-005-1208-3 CrossRefPubMed

21.

Ulfarsson E, Lindquist C, Roberts M, Rähn T, Lindquist M, Thorén M, Lippitz B (2002) Gamma knife radiosurgery for craniopharyngiomas: long-term results in the first Swedish patients. J Neurosurg 97(5 Suppl):613–622PubMed

22.

Voges J, Sturm V, Lehrke R, Treuer H, Gauss C, Berthold F (1997) Cystic craniopharyngioma: long-term results after intra-cavitary irradiation with stereotactically applied colloidal beta-emitting radioactive sources. Neurosurgery 40(2):263–270. doi:10.1097/00006123-199702000-00006 CrossRefPubMed

23.

Yaşargil MG, Curcic M, Kis M, Siegenthaler G, Teddy PJ, Roth P (1990) Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients. J Neurosurg 73(1):3–11CrossRefPubMed

Titel: Cystic craniopharyngioma: trans-sphenoidal surgery and intra-cystic apposition of “bleomycin wax”
verfasst von: Mario Francesco Fraioli
Laura Moschettoni
Elisabetta Catena
Chiara Fraioli
Publikationsdatum: 01.02.2010
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 2/2010
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0320-7

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Summary

Background

Case report

Results

Conclusions

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