Erschienen in:
01.12.2001 | Paper Report
Cytokine dysregulation in macrophages of lupus-prone mice
verfasst von:
Sylvie Fournel
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
In systemic lupus erythematosus (SLE), various autoantibodies recognize antigens that are modified and relocalized during apoptosis, suggesting that apoptotic cells may play a role in breakdown of tolerance and disease development. However, very little is known about intracellular signaling events induced by uptake of apoptotic cells. The authors have already reported that peritoneal and bone-marrow-derived macrophages from prediseased MRL/++ and MRL/lpr SLE-prone mice display a defect in lipopolysaccharide (LPS)-induced expression of several cytokines when compared with peritoneal macrophages derived from BALB/c mice. Therefore they investigated if these defects are present in other lupus-prone murine strains, and if apoptotic cells participate in these defects. …