Erschienen in:
01.12.2000 | Paper Report
Immunomodulation by statins
verfasst von:
Cheryl Smythe
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
Statins inhibit an important regulatory step in cholesterol biosynthesis that results in the reduction of circulating cholesterol levels. Treatment with statins, therefore, considerably reduces the risk of coronary heart disease. In addition to their lipid-lowering effects, statins have also been identified as having antioxidant, anti-inflammatory and angiogenic properties. In order to investigate whether statins may modulate immune responses, the authors studied the effect of a variety of statins on interferon (IFN)-?-inducible major histocompatability complex class II (MHC-II) expression and subsequent lymphocyte activation. …