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International Urogynecology Journal

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01.01.2010 | Original Article

Decreased nanobacteria levels and symptoms of nanobacteria-associated interstitial cystitis/painful bladder syndrome after tetracycline treatment

verfasst von: Qing-hua Zhang, Xue-cheng Shen, Zhan-song Zhou, Zhi-wen Chen, Gen-sheng Lu, Bo Song

Erschienen in: International Urogynecology Journal | Ausgabe 1/2010

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Abstract

Introduction and hypothesis

This study was designed to detect whether nanobacteria (NB) reside in urine and bladder tissue samples of patients with interstitial cystitis/painful bladder syndrome (IC/PBS) and whether antibiotic therapy targeting these organisms is effective in reducing NB levels and IC/PBS symptoms.

Methods

Twenty-seven IC/PBS patients underwent cystoscopy. Bladder biopsies and urine samples were obtained and cultured for NB, which were identified by indirect immunofluorescent staining and transmission electron microscopy.

Results

Eleven bladder samples showed growth of microbes that were identified to be similar to NB. Homologous study of the 16S ribosomal RNA gene suggested that the NB could be the pathogen. For enrolled 11 patients, NB levels decreased dramatically after tetracycline treatment, and they reported significant reduction in the severity of IC/PBS symptoms.

Conclusions

A high prevalence of NB was observed in female IC/PBS, and anti-NB treatment effectively improved the symptoms, which suggest that NB may cause some cases of IC/PBS.

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Titel: Decreased nanobacteria levels and symptoms of nanobacteria-associated interstitial cystitis/painful bladder syndrome after tetracycline treatment
verfasst von: Qing-hua Zhang
Xue-cheng Shen
Zhan-song Zhou
Zhi-wen Chen
Gen-sheng Lu
Bo Song
Publikationsdatum: 01.01.2010
Verlag: Springer-Verlag
Erschienen in: International Urogynecology Journal / Ausgabe 1/2010
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-009-0994-7

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Springer Medizin

Decreased nanobacteria levels and symptoms of nanobacteria-associated interstitial cystitis/painful bladder syndrome after tetracycline treatment

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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Springer Medizin

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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