nach oben

Erschienen in:

06.03.2018 | Review

Deep brain stimulation in uncommon tremor disorders: indications, targets, and programming

verfasst von: Carlo Alberto Artusi, Ashar Farooqi, Alberto Romagnolo, Luca Marsili, Roberta Balestrino, Leonard L. Sokol, Lily L. Wang, Maurizio Zibetti, Andrew P. Duker, George T. Mandybur, Leonardo Lopiano, Aristide Merola

Erschienen in: Journal of Neurology | Ausgabe 11/2018

Einloggen, um Zugang zu erhalten

Abstract

Background

In uncommon tremor disorders, clinical efficacy and optimal anatomical targets for deep brain stimulation (DBS) remain inadequately studied and insufficiently quantified.

Methods

We performed a systematic review of PubMed.gov and ClinicalTrials.gov. Relevant articles were identified using the following keywords: “tremor”, “Holmes tremor”, “orthostatic tremor”, “multiple sclerosis”, “multiple sclerosis tremor”, “neuropathy”, “neuropathic tremor”, “fragile X-associated tremor/ataxia syndrome”, and “fragile X.”

Results

We identified a total of 263 cases treated with DBS for uncommon tremor disorders. Of these, 44 had Holmes tremor (HT), 18 orthostatic tremor (OT), 177 multiple sclerosis (MS)-associated tremor, 14 neuropathy-associated tremor, and 10 fragile X-associated tremor/ataxia syndrome (FXTAS). DBS resulted in favorable, albeit partial, clinical improvements in HT cases receiving Vim-DBS alone or in combination with additional targets. A sustained improvement was reported in OT cases treated with bilateral Vim-DBS, while the two cases treated with unilateral Vim-DBS demonstrated only a transient effect. MS-associated tremor responded to dual-target Vim-/VO-DBS, but the inability to account for the progression of MS-associated disability impeded the assessment of its long-term clinical efficacy. Neuropathy-associated tremor substantially improved with Vim-DBS. In FXTAS patients, while Vim-DBS was effective in improving tremor, equivocal results were observed in those with ataxia.

Conclusions

DBS of select targets may represent an effective therapeutic strategy for uncommon tremor disorders, although the level of evidence is currently in its incipient form and based on single cases or limited case series. An international registry is, therefore, warranted to clarify selection criteria, long-term results, and optimal surgical targets.

Bhatia KP, Bain P, Bajaj N et al (2018) Consensus Statement on the classification of tremors. From the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord 33:75–87. https://doi.org/10.1002/mds.27121 CrossRefPubMed

Tysnes OB, Storstein A (2017) Epidemiology of Parkinson’s disease. J Neural Transm (Vienna) 124:901–905. https://doi.org/10.1007/s00702-017-1686-y CrossRef

Louis ED, Ferreira JJ (2010) How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord 25:534–541. https://doi.org/10.1002/mds.22838 CrossRefPubMed

Deuschl G, Bain P, Brin M (1998) Consensus statement of the Movement Disorder Society on Tremor. Ad Hoc Scientific Committee. Mov Disord 13(Suppl 3):2–23PubMed

Remy P, de Recondo A, Defer G et al (1995) Peduncular “rubral” tremor and dopaminergic denervation: a PET study. Neurology 45:472–477CrossRef

Seidel S, Kasprian G, Leutmezer F, Prayer D, Auff E (2009) Disruption of nigrostriatal and cerebellothalamic pathways in dopamine responsive Holmes’ tremor. J Neurol Neurosurg Psychiatry 80:921–923. https://doi.org/10.1136/jnnp.2008.146324 CrossRefPubMed

Hassan A, Ahlskog JE, Matsumoto JY et al (2016) Orthostatic tremor: clinical, electrophysiologic, and treatment findings in 184 patients. Neurology 86:458–464. https://doi.org/10.1212/WNL.0000000000002328 CrossRefPubMed

Gallea C, Popa T, García-Lorenzo D et al (2016) Orthostatic tremor: a cerebellar pathology? Brain 139:2182–2197. https://doi.org/10.1093/brain/aww140 CrossRefPubMedPubMedCentral

Rinker JR, Salter AR, Walker H et al (2015) Prevalence and characteristics of tremor in the NARCOMS multiple sclerosis registry: a cross-sectional survey. BMJ Open 5:e006714. https://doi.org/10.1136/bmjopen-2014-006714 CrossRefPubMedPubMedCentral

10.

Bain PG (2002) The management of tremor. J Neurol Neurosurg Psychiatry 72:I3–I9PubMedPubMedCentral

11.

Bain PG, Britton TC, Jenkins IH et al (1996) Tremor associated with benign IgM paraproteinaemic neuropathy. Brain 119:789–799CrossRef

12.

Weiss D, Govindan RB, Rilk A et al (2011) Central oscillators in a patient with neuropathic tremor: evidence from intraoperative local field potential recordings. Mov Disord 26:323–327. https://doi.org/10.1002/mds.23374 CrossRefPubMed

13.

Hagerman RJ, Hagerman P (2016) Fragile X-associated tremor/ataxia syndrome—features, mechanisms and management. Nat Rev Neurol 12:403–412. https://doi.org/10.1038/nrneurol.2016.82 CrossRefPubMed

14.

Hagerman RJ, Hall DA, Coffey S et al (2008) Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems. Clin Interv Aging 3:251–262CrossRef

15.

Puschmann A, Wszolek ZK (2011) Diagnosis and treatment of common forms of tremor. Semin Neurol 31:65–77. https://doi.org/10.1055/s-0031-1271312 CrossRefPubMedPubMedCentral

16.

Hyam JA, Pereira EAC, McCulloch P et al (2015) Implementing novel trial methods to evaluate surgery for essential tremor. Br J Neurosurg 29:334–339. https://doi.org/10.3109/02688697.2014.997670 CrossRefPubMed

17.

Ramirez-Zamora A, Okun MS (2016) Deep brain stimulation for the treatment of uncommon tremor syndromes. Expert Rev Neurother 16:983–997. https://doi.org/10.1080/14737175.2016.1194756 CrossRefPubMedPubMedCentral

18.

Kudo M, Goto S, Nishikawa S et al (2001) Bilateral thalamic stimulation for Holmes’ tremor caused by unilateral brainstem lesion. Mov Disord 16:170–174CrossRef

19.

Goto S, Yamada K (2004) Combination of thalamic Vim stimulation and GPi pallidotomy synergistically abolishes Holmes’ tremor. J Neurol Neurosurg Psychiatry 75:1203–1204. https://doi.org/10.1136/jnnp.2003.023077 CrossRefPubMedPubMedCentral

20.

Pahwa R, Lyons KE, Kempf L, Wilkinson SB, Koller WC (2002) Thalamic stimulation for midbrain tremor after partial hemangioma resection. Mov Disord 17:404–407CrossRef

21.

Romanelli P, Brontë-Stewart H, Courtney T, Heit G (2003) Possible necessity for deep brain stimulation of both the ventralis intermedius and subthalamic nuclei to resolve Holmes tremor. Case report. J Neurosurg 99:566–571. https://doi.org/10.3171/jns.2003.99.3.0566 CrossRefPubMed

22.

Samadani U, Umemura A, Jaggi JL et al (2003) Thalamic deep brain stimulation for disabling tremor after excision of a midbrain cavernous angioma. Case report. J Neurosurg 98:888–890. https://doi.org/10.3171/jns.2003.98.4.0888 CrossRefPubMed

23.

Nikkhah G, Prokop T, Hellwig B, Lücking CH, Ostertag CB (2004) Deep brain stimulation of the nucleus ventralis intermedius for Holmes (rubral) tremor and associated dystonia caused by upper brainstem lesions. Report of two cases. J Neurosurg 100:1079–1083. https://doi.org/10.3171/jns.2004.100.6.1079 CrossRefPubMed

24.

Piette T, Mescola P, Henriet M et al (2004) A surgical approach to Holmes’ tremor associated with high-frequency synchronous bursts. Rev Neurol (Paris) 160:707–711CrossRef

25.

Foote KD, Seignourel P, Fernandez HH et al (2006) Dual electrode thalamic deep brain stimulation for the treatment of posttraumatic and multiple sclerosis tremor. Neurosurgery 58:ONS-280–ONS-285 (discussion ONS-285–ONS-286)

26.

Lim DA, Khandhar SM, Heath S et al (2007) Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes’ tremor. Stereotact Funct Neurosurg 85:144–149. https://doi.org/10.1159/000099072 CrossRefPubMed

27.

Diederich NJ, Verhagen Metman L, Bakay RA, Alesch F (2008) Ventral intermediate thalamic stimulation in complex tremor syndromes. Stereotact Funct Neurosurg 86:167–172. https://doi.org/10.1159/000120429 CrossRefPubMed

28.

Peker S, Isik U, Akgun Y, Ozek M (2008) Deep brain stimulation for Holmes’ tremor related to a thalamic abscess. Childs Nerv Syst 24:1057–1062. https://doi.org/10.1007/s00381-008-0644-2 CrossRefPubMed

29.

Acar G, Acar F, Bir LS, Kızılay Z, Cırak B (2010) Vim stimulation in Holmes’ tremor secondary to subarachnoid hemorrhage. Neurol Res 32:992–994. https://doi.org/10.1179/016164110X12714125204272 CrossRefPubMed

30.

Aydin S, Abuzayed B, Kiziltan G et al (2013) Unilateral thalamic Vim and GPi stimulation for the treatment of Holmes’ tremor caused by midbrain cavernoma: case report and review of the literature. J Neurol Surg A Cent Eur Neurosurg 74:271–276. https://doi.org/10.1055/s-0032-1322549 CrossRefPubMed

31.

Castrop F, Jochim A, Berends LP, Haslinger B (2013) Sustained suppression of holmes tremor after cessation of thalamic stimulation. Mov Disord 28:1456–1457. https://doi.org/10.1002/mds.25398 CrossRefPubMed

32.

Issar NM, Hedera P, Phibbs FT, Konrad PE, Neimat JS (2013) Treating post-traumatic tremor with deep brain stimulation: report of five cases. Parkinsonism Relat Disord 19:1100–1105. https://doi.org/10.1016/j.parkreldis.2013.07.022 CrossRefPubMed

33.

Follett MA, Torres-Russotto D, Follett KA (2014) Bilateral deep brain stimulation of the ventral intermediate nucleus of the thalamus for posttraumatic midbrain tremor. Neuromodulation 17:289–291. https://doi.org/10.1111/ner.12096 CrossRefPubMed

34.

Kobayashi K, Katayama Y, Oshima H et al (2014) Multitarget, dual-electrode deep brain stimulation of the thalamus and subthalamic area for treatment of Holmes’ tremor. J Neurosurg 120:1025–1032. https://doi.org/10.3171/2014.1.JNS12392 CrossRefPubMed

35.

Espinoza Martinez JA, Arango GJ, Fonoff ET et al (2015) Deep brain stimulation of the globus pallidus internus or ventralis intermedius nucleus of thalamus for Holmes tremor. Neurosurg Rev 38:753–763. https://doi.org/10.1007/s10143-015-0636-0 CrossRefPubMed

36.

Kilbane C, Ramirez-Zamora A, Ryapolova-Webb E et al (2015) Pallidal stimulation for Holmes tremor: clinical outcomes and single-unit recordings in 4 cases. J Neurosurg 122:1306–1314. https://doi.org/10.3171/2015.2.JNS141098 CrossRefPubMed

37.

Aydın S, Canaz H, Erdogan ET, Durmaz N, Topcular B (2017) Holmes’ tremor with shoulder pain treated by deep brain stimulation of unilateral ventral intermediate thalamic nucleus and globus pallidus internus. J Mov Disord 10:92–95. https://doi.org/10.14802/jmd.16051 CrossRefPubMedPubMedCentral

38.

Toda H, Nishida N, Iwasaki K (2017) Coaxial interleaved stimulation of the thalamus and subthalamus for treatment of Holmes tremor. Neurosurg Focus 42:V1. https://doi.org/10.3171/2017.4.FocusVid.16510 CrossRefPubMed

39.

Plaha P, Khan S, Gill SS (2008) Bilateral stimulation of the caudal zona incerta nucleus for tremor control. J Neurol Neurosurg Psychiatry 79:504–513. https://doi.org/10.1136/jnnp.2006.112334 CrossRefPubMed

40.

Bandt SK, Anderson D, Biller J (2008) Deep brain stimulation as an effective treatment option for post-midbrain infarction-related tremor as it presents with Benedikt syndrome. J Neurosurg 109:635–639. https://doi.org/10.3171/JNS/2008/109/10/0635 CrossRefPubMed

41.

Grabska N, Rudzińska M, Dec-Ćwiek M et al (2014) Deep brain stimulation in the treatment of Holmes tremor—a long-term case observation. Neurol Neurochir Pol 48:292–295. https://doi.org/10.1016/j.pjnns.2014.06.002 CrossRefPubMed

42.

Espay AJ, Duker AP, Chen R et al (2008) Deep brain stimulation of the ventral intermediate nucleus of the thalamus in medically refractory orthostatic tremor: preliminary observations. Mov Disord 23:2357–2362. https://doi.org/10.1002/mds.22271 CrossRefPubMed

43.

Guridi J, Rodriguez-Oroz MC, Arbizu J et al (2008) Successful thalamic deep brain stimulation for orthostatic tremor. Mov Disord 23:1808–1811. https://doi.org/10.1002/mds.22001 CrossRefPubMed

44.

Magariños-Ascone C, Ruiz FM, Millán AS et al (2010) Electrophysiological evaluation of thalamic DBS for orthostatic tremor. Mov Disord 25:2476–2477. https://doi.org/10.1002/mds.23333 CrossRefPubMed

45.

Yaltho TC, Ondo WG (2011) Thalamic deep brain stimulation for orthostatic tremor. Tremor Other Hyperkinet Mov (N Y). https://doi.org/10.7916/D8NZ86C1 CrossRef

46.

Lyons MK, Behbahani M, Boucher OK, Caviness JN, Evidente VG (2012) Orthostatic tremor responds to bilateral thalamic deep brain stimulation. Tremor Other Hyperkinet Mov (N Y). https://doi.org/10.7916/D8TQ608K CrossRef

47.

Contarino MF, Bour LJ, Schuurman PR et al (2015) Thalamic deep brain stimulation for orthostatic tremor: clinical and neurophysiological correlates. Parkinsonism Relat Disord 21:1005–1007. https://doi.org/10.1016/j.parkreldis.2015.06.008 CrossRefPubMed

48.

Coleman RR, Starr PA, Katz M et al (2016) Bilateral ventral intermediate nucleus thalamic deep brain stimulation in orthostatic tremor. Stereotact Funct Neurosurg 94:69–74. https://doi.org/10.1159/000444127 CrossRefPubMed

49.

Lehn AC, O’Gorman C, Olson S, Salari M (2017) Thalamic ventral intermediate nucleus deep brain stimulation for orthostatic tremor. Tremor Other Hyperkinet Mov (N Y) 7:479. https://doi.org/10.7916/D8280JHR CrossRef

50.

Merola A, Fasano A, Hassan A et al (2017) Thalamic deep brain stimulation for orthostatic tremor: a multicenter international registry. Mov Disord 32:1240–1244. https://doi.org/10.1002/mds.27082 CrossRefPubMed

51.

Nguyen JP, Degos JD (1993) Thalamic stimulation and proximal tremor. A specific target in the nucleus ventrointermedius thalami. Arch Neurol 50:498–500CrossRef

52.

Siegfried J, Lippitz B (1994) Chronic electrical stimulation of the VL-VPL complex and of the pallidum in the treatment of movement disorders: personal experience since 1982. Stereotact Funct Neurosurg 62:71–75. https://doi.org/10.1159/000098599 CrossRefPubMed

53.

Benabid AL, Pollak P, Gao D et al (1996) Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J Neurosurg 84:203–214. https://doi.org/10.3171/jns.1996.84.2.0203 CrossRefPubMed

54.

Geny C, Nguyen J-P, Pollin B et al (1996) Improvement of severe postural cerebellar tremor in multiple sclerosis by chronic thalamic stimulation. Mov Disord 11:489–494. https://doi.org/10.1002/mds.870110503 CrossRefPubMed

55.

Montgomery EB, Baker KB, Kinkel RP, Barnett G (1999) Chronic thalamic stimulation for the tremor of multiple sclerosis. Neurology 53:625–628CrossRef

56.

Schulder M, Sernas T, Mahalick D, Adler R, Cook S (1999) Thalamic stimulation in patients with multiple sclerosis. Stereotact Funct Neurosurg 72:196–201. https://doi.org/10.1159/000029726 CrossRefPubMed

57.

Taha JM, Janszen MA, Favre J (1999) Thalamic deep brain stimulation for the treatment of head, voice, and bilateral limb tremor. J Neurosurg 91:68–72. https://doi.org/10.3171/jns.1999.91.1.0068 CrossRefPubMed

58.

Krauss JK, Simpson RK, Ondo WG et al (2001) Concepts and methods in chronic thalamic stimulation for treatment of tremor: technique and application. Neurosurgery 48:535–541 (discussion 541–543) CrossRef

59.

Hooper J, Taylor R, Pentland B, Whittle IR (2002) A prospective study of thalamic deep brain stimulation for the treatment of movement disorders in multiple sclerosis. Br J Neurosurg 16:102–109CrossRef

60.

Berk C, Carr J, Sinden M, Martzke J, Honey CR (2002) Thalamic deep brain stimulation for the treatment of tremor due to multiple sclerosis: a prospective study of tremor and quality of life. J Neurosurg 97:815–820. https://doi.org/10.3171/jns.2002.97.4.0815 CrossRefPubMed

61.

Herzog J, Hamel W, Wenzelburger R et al (2007) Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremor. Brain 130:1608–1625. https://doi.org/10.1093/brain/awm077 CrossRefPubMed

62.

Schuurman PR, Bosch DA, Merkus MP, Speelman JD (2008) Long-term follow-up of thalamic stimulation versus thalamotomy for tremor suppression. Mov Disord 23:1146–1153. https://doi.org/10.1002/mds.22059 CrossRefPubMed

63.

Moore GRW, Vitali AM, Leung E et al (2009) Thalamic stimulation in multiple sclerosis: evidence for a “demyelinative thalamotomy”. Mult Scler 15:1311–1321. https://doi.org/10.1177/1352458509345914 CrossRefPubMed

64.

Mandat T, Koziara H, Tutaj M et al (2010) Thalamic deep brain stimulation for tremor among multiple sclerosis patients. Neurol Neurochir Pol 44:542–545. https://doi.org/10.1016/S0028-3843(14)60150-X CrossRefPubMed

65.

Torres CV, Moro E, Lopez-Rios A-L et al (2010) Deep brain stimulation of the ventral intermediate nucleus of the thalamus for tremor in patients with multiple sclerosis. Neurosurgery 67:646–651. https://doi.org/10.1227/01.NEU.0000375506.18902.3E CrossRefPubMed

66.

Hassan A, Ahlskog JE, Rodriguez M, Matsumoto JY (2012) Surgical therapy for multiple sclerosis tremor: a 12-year follow-up study. Eur J Neurol 19:764–768. https://doi.org/10.1111/j.1468-1331.2011.03626.x CrossRefPubMed

67.

Hosseini H, Mandat T, Waubant E et al (2012) Unilateral thalamic deep brain stimulation for disabling kinetic tremor in multiple sclerosis. Neurosurgery 70:66–69. https://doi.org/10.1227/NEU.0b013e31822da55c CrossRefPubMed

68.

Zakaria R, Vajramani G, Westmoreland L et al (2013) Tremor reduction and quality of life after deep brain stimulation for multiple sclerosis-associated tremor. Acta Neurochir (Wien) 155:2359–2364. https://doi.org/10.1007/s00701-013-1848-0 CrossRef

69.

Mehanna R, Machado AG, Oravivattanakul S, Genc G, Cooper SE (2014) Comparing two deep brain stimulation leads to one in refractory tremor. Cerebellum 13:425–432. https://doi.org/10.1007/s12311-014-0552-9 CrossRefPubMed

70.

Oliveria SF, Rodriguez RL, Bowers D et al (2017) Safety and efficacy of dual-lead thalamic deep brain stimulation for patients with treatment-refractory multiple sclerosis tremor: a single-centre, randomised, single-blind, pilot trial. Lancet Neurol 16:691–700. https://doi.org/10.1016/S1474-4422(17)30166-7 CrossRefPubMed

71.

Nandi D, Aziz TZ (2004) Deep brain stimulation in the management of neuropathic pain and multiple sclerosis tremor. J Clin Neurophysiol 21:31–39CrossRef

72.

Thevathasan W, Schweder P, Joint C et al (2011) Permanent tremor reduction during thalamic stimulation in multiple sclerosis. J Neurol Neurosurg Psychiatry 82:419–422. https://doi.org/10.1136/jnnp.2010.213900 CrossRefPubMed

73.

Whittle IR, Yau YH, Hooper J (2004) Mesodiencephalic targeting of stimulating electrodes in patients with tremor caused by multiple sclerosis. J Neurol Neurosurg Psychiatry 75:1210PubMedPubMedCentral

74.

Hamel W, Herzog J, Kopper F et al (2007) Deep brain stimulation in the subthalamic area is more effective than nucleus ventralis intermedius stimulation for bilateral intention tremor. Acta Neurochir (Wien) 149:749–758. https://doi.org/10.1007/s00701-007-1230-1 CrossRef

75.

Růzicka E, Jech R, Zárubová K, Roth J, Urgosík D (2003) VIM thalamic stimulation for tremor in a patient with IgM paraproteinaemic demyelinating neuropathy. Mov Disord 18:1192–1195. https://doi.org/10.1002/mds.10510 CrossRefPubMed

76.

Bayreuther C, Delmont E, Borg M, Fontaine D (2009) Deep brain stimulation of the ventral intermediate thalamic nucleus for severe tremor in anti-MAG neuropathy. Mov Disord 24:2157–2158. https://doi.org/10.1002/mds.22604 CrossRefPubMed

77.

Breit S, Wächter T, Schöls L et al (2009) Effective thalamic deep brain stimulation for neuropathic tremor in a patient with severe demyelinating neuropathy. J Neurol Neurosurg Psychiatry 80:235–236. https://doi.org/10.1136/jnnp.2008.145656 CrossRefPubMed

78.

McMaster J, Gibson G, Castro-Prado F, Vitali A, Honey CR (2009) Neurosurgical treatment of tremor in anti-myelin-associated glycoprotein neuropathy. Neurology 73:1707–1708. https://doi.org/10.1212/WNL.0b013e3181c1de66 CrossRefPubMed

79.

Shields DC, Flaherty AW, Eskandar EN, Williams ZM (2011) Ventral intermediate thalamic stimulation for monoclonal gammopathy-associated tremor: case report. Neurosurgery 68:E1464–E1467. https://doi.org/10.1227/NEU.0b013e3182124633 CrossRefPubMed

80.

Patel N, Ondo W, Jimenez-Shahed J (2014) Habituation and rebound to thalamic deep brain stimulation in long-term management of tremor associated with demyelinating neuropathy. Int J Neurosci 124:919–925. https://doi.org/10.3109/00207454.2014.895345 CrossRefPubMed

81.

Cabañes-Martínez L, Álamo Del, de Pedro M, de Blas Beorlegui G, Bailly-Bailliere IR (2017) Long-term effective thalamic deep brain stimulation for neuropathic tremor in two patients with Charcot–Marie–Tooth disease. Stereotact Funct Neurosurg 95:102–106. https://doi.org/10.1159/000457963 CrossRefPubMed

82.

Blomstedt P, Fytagoridis A, Tisch S (2009) Deep brain stimulation of the posterior subthalamic area in the treatment of tremor. Acta Neurochir (Wien) 151:31–36. https://doi.org/10.1007/s00701-008-0163-7 CrossRef

83.

Ferrara JM, Adam OR, Ondo WG (2009) Treatment of fragile-X-associated tremor/ataxia syndrome with deep brain stimulation. Mov Disord 24:149–151. https://doi.org/10.1002/mds.22354 CrossRefPubMed

84.

Senova S, Jarraya B, Iwamuro H et al (2012) Unilateral thalamic stimulation safely improved fragile X-associated tremor ataxia: a case report. Mov Disord 27:797–799. https://doi.org/10.1002/mds.24923 CrossRefPubMed

85.

Xie T, Goodman R, Browner N et al (2012) Treatment of fragile X-associated tremor/ataxia syndrome with unilateral deep brain stimulation. Mov Disord 27:799–800. https://doi.org/10.1002/mds.24958 CrossRefPubMed

86.

Mehanna R, Itin I (2014) Which approach is better: bilateral versus unilateral thalamic deep brain stimulation in patients with fragile X-associated tremor ataxia syndrome. Cerebellum 13:222–225. https://doi.org/10.1007/s12311-013-0530-7 CrossRefPubMed

87.

Weiss D, Mielke C, Wächter T et al (2015) Long-term outcome of deep brain stimulation in fragile X-associated tremor/ataxia syndrome. Parkinsonism Relat Disord 21:310–313. https://doi.org/10.1016/j.parkreldis.2014.12.015 CrossRefPubMed

88.

Tamás G, Kovács N, Varga NÁ et al (2016) Deep brain stimulation or thalamotomy in fragile X-associated tremor/ataxia syndrome? Case report. Neurol Neurochir Pol 50:303–308. https://doi.org/10.1016/j.pjnns.2016.04.004 CrossRefPubMed

89.

dos Santos Ghilardi MG, Cury RG, dos Ângelos JS et al (2015) Long-term improvement of tremor and ataxia after bilateral DBS of VoP/zona incerta in FXTAS. Neurology 84:1904–1906. https://doi.org/10.1212/WNL.0000000000001553 CrossRefPubMed

90.

Oyama G, Umemura A, Shimo Y et al (2014) Posterior subthalamic area deep brain stimulation for fragile X-associated tremor/ataxia syndrome. Neuromodulation 17:721–723. https://doi.org/10.1111/ner.12150 CrossRefPubMed

91.

di Biase L, Munhoz RP (2016) Deep brain stimulation for the treatment of hyperkinetic movement disorders. Expert Rev Neurother 16:1067–1078. https://doi.org/10.1080/14737175.2016.1196139 CrossRefPubMed

92.

Koch M, Mostert J, Heersema D, De Keyser J (2007) Tremor in multiple sclerosis. J Neurol 254:133–145. https://doi.org/10.1007/s00415-006-0296-7 CrossRefPubMedPubMedCentral

93.

Van Der Walt A, Sung S, Spelman T et al (2012) A double-blind, randomized, controlled study of botulinum toxin type A in MS-related tremor. Neurology 79:92–99. https://doi.org/10.1212/WNL.0b013e31825dcdd9 CrossRef

94.

Charles PD, Esper GJ, Davis TL, Maciunas RJ, Robertson D (1999) Classification of tremor and update on treatment. Am Fam Physician 59:1565–1572PubMed

Titel: Deep brain stimulation in uncommon tremor disorders: indications, targets, and programming
verfasst von: Carlo Alberto Artusi
Ashar Farooqi
Alberto Romagnolo
Luca Marsili
Roberta Balestrino
Leonard L. Sokol
Lily L. Wang
Maurizio Zibetti
Andrew P. Duker
George T. Mandybur
Leonardo Lopiano
Aristide Merola
Publikationsdatum: 06.03.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 11/2018
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-018-8823-x

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

25.04.2024 | Hypotonie | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Deep brain stimulation in uncommon tremor disorders: indications, targets, and programming

Abstract

Background

Methods

Results

Conclusions

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Frühe Alzheimertherapie lohnt sich

Viel Bewegung in der Parkinsonforschung

Demenzkranke durch Antipsychotika vielfach gefährdet

Update Neurologie

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2018

Quality of life in a German cohort of Parkinson’s patients assessed with three different measures

StartReact during gait initiation reveals differential control of muscle activation and inhibition in patients with corticospinal degeneration

Vertigo and impaired pursuit eye movements in a small medial superior temporal infarction

Ciclosporin and chorea: a new association?

Monitoring and management of autoimmunity in multiple sclerosis patients treated with alemtuzumab: practical recommendations

Effect of anti-seizure drugs on serum S100B in patients with focal seizure: a randomized controlled trial

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Frühe Alzheimertherapie lohnt sich

Viel Bewegung in der Parkinsonforschung

Demenzkranke durch Antipsychotika vielfach gefährdet

Update Neurologie