Background
Methods
Study population
Characteristic | Glioma Cases | ||
---|---|---|---|
Totala
| Microscopically confirmed with specific morphology | ||
N | N | Percent | |
Age (years)
| |||
20-24 | 812 | 699 | 86.1% |
25-29 | 1,308 | 1,171 | 89.5% |
30-34
|
1,709
|
1,553
|
90.9%
|
35-39
|
2,194
|
2,038
|
92.9%
|
40-44
|
2,730
|
2,522
|
92.4%
|
45-49
|
3,224
|
3,003
|
93.1%
|
50-54
|
3,879
|
3,607
|
93.0%
|
55-59
|
4,133
|
3,835
|
92.8%
|
60-64
|
4,253
|
3,917
|
92.1%
|
65-69
|
4,252
|
3,865
|
90.9%
|
70-74 | 4,530 | 3,948 | 87.2% |
75-79 | 4,081 | 3,353 | 82.2% |
80-84 | 2,579 | 1,793 | 69.5% |
85+ | 1,448 | 663 | 45.8% |
Total, age 30-69 years
|
26,374
|
24,340
|
92.3%
|
Period (age 30-69 years)
| |||
1992-1995 | 4,121 | 3,813 | 92.5% |
1996-1999 | 4,345 | 4,006 | 92.2% |
2000-2003 | 8,606 | 7,916 | 92.0% |
2004-2007 | 9,302 | 8,605 | 92.5% |
Sex (age 30-69 years)
| |||
Male | 15,607 | 14,414 | 92.4% |
Female | 10,767 | 9,926 | 92.2% |
Race/ethnic group (age 30-69 years)
| |||
Non-Hispanic White | 20,860 | 19,354 | 92.8% |
Hispanic White | 2,735 | 2,487 | 90.9% |
Black | 1,444 | 1,297 | 89.8% |
Asian/Pacific Islander | 1,222 | 1,098 | 89.9% |
American Indian/Alaskan Native | |||
Native | 113 | 104 | 92.0% |
Data analysis and statistical methods
Results
Race/ethnic group
Glioma | ||||||||
---|---|---|---|---|---|---|---|---|
Subtype | Race/ethnic group | Males | Females | Male/Female | ||||
Cases | ASRa (95% CIb) | RRc (95% CIb) | Cases | ASRa (95% CIb) | RRc (95% CIb) | RRd (95% CIb) | ||
GBM
| ||||||||
Non-Hispanic White | 7,458 | 5.20 (5.06, 5.32) | 1.00 (reference) | 4,745 | 3.16 (3.07, 3.25) | 1.00 (reference) | 1.64 (1.58, 1.70) | |
Hispanic White | 769 | 3.08 (2.86, 3.31) | 0.58 (0.54, 0.62) | 625 | 2.34 (2.16, 2.53) | 0.74 (0.68, 0.80) | 1.31 (1.18, 1.45) | |
Black | 470 | 2.51 (2.28, 2.74) | 0.48 (0.44, 0.53) | 352 | 1.56 (1.40, 1.73) | 0.49 (0.44, 0.55) | 1.61 (1.40, 1.85) | |
Asian/Pacific Islander | 372 | 1.94 (1.75, 2.14) | 0.38 (0.34, 0.42) | 245 | 1.12 (0.98, 1.26) | 0.35 (0.31, 0.40) | 1.74 (1.48, 2.05) | |
American Indian/Alaskan Native | 29 | 1.26 (0.79, 1.73) | 0.25 (0.17, 0.36) | 23 | 0.95 (0.56, 1.35) | 0.30 (0.20, 0.45) | 1.36 (0.78, 2.34) | |
Total | 9,098 | 5,990 | 1.61e (1.56, 1.66) | |||||
Non-GBM
| ||||||||
Non-Hispanic White | 4,175 | 3.01 (2.91, 3.10) | 1.00 (reference) | 2,976 | 2.12 (2.04, 2.19) | 1.00 (reference) | 1.42 (1.36, 1.49) | |
Hispanic White | 577 | 1.85 (1.69, 2.00) | 0.59 (0.54, 0.65) | 516 | 1.64 (1.49, 1.78) | 0.76 (0.70, 0.84) | 1.10 (0.98, 1.24) | |
Black | 269 | 1.30 (1.14, 1.45) | 0.43 (0.38, 0.49) | 206 | 0.85 (0.74, 0.97) | 0.40 (0.35, 0.46) | 1.52 (1.26, 1.82) | |
Asian/Pacific Islander | 264 | 1.29 (1.13, 1.45) | 0.43 (0.38, 0.49) | 217 | 0.95 (0.82, 1.08) | 0.45 (0.39, 0.52) | 1.35 (1.13, 1.62) | |
American Indian/Alaskan Native | 31 | 1.24 (0.79, 1.69) | 0.40 (0.28, 0.57) | 21 | 0.77 (0.44, 1.11) | 0.37 (0.24, 0.57) | 1.54 (0.88, 2.67) | |
Total | 5,316 | 3,936 | 1.38e (1.32, 1.44) |
Sex
GBM | Non-GBM | |||
---|---|---|---|---|
Age (years) | N | RRa (95% CIb) | N | RRa (95% CIb) |
30-44 (pre-menopausal) | 2,056 | 1.70 (1.56, 1.86) | 4,057 | 1.33 (1.25, 1.41) |
45-54 (peri-menopausal) | 4,135 | 1.61 (1.51, 1.71) | 2,475 | 1.36 (1.25, 1.47) |
55-69 (post-menopausal) | 8,897 | 1.59 (1.52, 1.66) | 2,720 | 1.48 (1.37, 1.60) |
p-value for heterogeneity
c
| 0.38 | 0.087 |
Age
Glioma | Malea
| Femalea
| Totalb
| |
---|---|---|---|---|
Subtype | Race/ethnic group | Slope (loge(age)) (95% CIc) | Slope (loge(age)) (95% CIc) | Slope (loge(age)) (95% CIc) |
GBM
| ||||
Total
d
| 4.12 (4.01, 4.23) | 4.24 (4.10, 4.38) | 4.17 (4.08, 4.26) | |
Non-Hispanic White | 4.09 (3.96, 4.21) | 4.23 (4.07, 4.39) | 4.14 (4.05, 4.24) | |
Hispanic White | 4.51 (4.17, 4.86) | 4.39 (3.99, 4.78) | 4.46 (4.20, 4.72) | |
Black | 4.29 (3.81, 4.76) | 4.38 (3.83, 4.94) | 4.33 (3.97, 4.69) | |
Asian/Pacific Islander | 3.70 (3.19, 4.21) | 3.83 (3.19, 4.47) | 3.75 (3.35, 4.15) | |
American Indian/Alaskan Native | 3.03 (1.28, 4.77) | 4.39 (2.21, 6.56) | 3.59 (2.23, 4.94) | |
p-value for heterogeneitye
| 0.044 | 0.68 | 0.021 | |
Non-GBM
| ||||
Total
d
| 0.52 (0.40, 0.64) | 0.43 (0.29, 0.56) | 0.48 (0.39, 0.57) | |
Non-Hispanic White | 0.43 (0.29, 0.56) | 0.38 (0.22, 0.54) | 0.41 (0.30, 0.51) | |
Hispanic White | 1.13 (0.77, 1.49) | 0.76 (0.38, 1.14) | 0.95 (0.69, 1.21) | |
Black | 0.88 (0.34, 1.41) | 0.68 (0.07, 1.29) | 0.79 (0.39, 1.19) | |
Asian/Pacific Islander | 0.38 (-0.15, 0.91) | 0.08 (-0.51, 0.66) | 0.24 (-0.15, 0.63) | |
American Indian/Alaskan Native | 0.46 (-1.13, 2.05) | 0.01 (-2.29, 1.61) | 0.14 (-1.09, 1.38) | |
p-value for heterogeneitye
| 0.0053 | 0.22 | 0.0005 |
Calendar period
GBM | Non-GBM | Totala
| ||||
---|---|---|---|---|---|---|
Period | N | RRb (95% CIc) | N | RRb (95% CIc) | N | RRb (95% CIc) |
1992-1995 | 2,181 | 1.00 (reference) | 1,632 | 1.00 (reference) | 3,813 | 1.00 (reference) |
1996-1999 | 2,351 | 1.03 (0.97, 1.09) | 1,655 | 0.97 (0.91, 1.04) | 4,006 | 1.00 (0.96, 1.05) |
2000-2003 | 4,930 | 1.02 (0.97, 1.07) | 2,986 | 0.87 (0.82, 0.92) | 7,916 | 0.95 (0.92, 0.99) |
2004-2007 | 5,626 | 1.06 (1.01, 1.12) | 2,979 | 0.84 (0.79, 0.89) | 8,605 | 0.97 (0.93, 1.01) |
p-value, trendd
| 0.012 | < 0.0001 | 0.037 |