Background
Methods
Patients
Data extraction and additional calculations
Statistical analysis
Results
Comparison of clinical and hemodynamic characteristics in aortic stenosis patients with and without concomitant T2DM
Characteristic | T2DM n = 50 | No diabetes n = 80 | p value |
---|---|---|---|
Age (years) | 70 ± 9 | 70 ± 11 | n.s. |
Men/Women, n (%) | 23/27 (46/54%) | 44/36 (55/45%) | n.s. |
Symptoms, n (%)a | 31 (62%) | 41 (51%) | n.s. |
Hypertension, n (%) | 45 (90%) | 62 (78%) | n.s. |
Chronic kidney disease, n (%) | 16 (32%) | 17 (21%) | n.s. |
Body-mass index (kg/m2) | 31 ± 5 | 28 ± 4 | 0.003 |
Mean blood pressure (mm Hg) | 90 ± 10 | 89 ± 10 | n.s. |
Systolic blood pressure (mm Hg) | 131 ± 16 | 130 ± 18 | n.s. |
Glycated hemoglobin (%) | 7.1 ± 0.8 | – | – |
Medications, n (%) | |||
ACEI or ARB | 30 (60%) | 43 (54%) | n.s. |
Beta-blocker | 25 (50%) | 34 (43%) | n.s. |
Diuretic | 20 (40%) | 27 (34%) | n.s. |
Calcium channel blockers | 17 (34%) | 24 (30%) | n.s. |
Statin | 38 (76%) | 50 (62%) | n.s. |
Metformin | 47 (94%) | – | – |
Insulin | 16 (32%) | – | – |
Characteristic | T2DM n = 50 | No diabetes n = 80 | p value |
---|---|---|---|
Aortic valve area index (cm2/m2) | 0.50 ± 0.17 | 0.52 ± 0.16 | n.s. |
Mean aortic pressure gradient (mm Hg) | 41 ± 24 | 40 ± 21 | n.s. |
LV end-diastolic diameter (cm) | 5.1 ± 0.9 | 5.1 ± 1.0 | n.s. |
LV mass index (g/m2) | 143 ± 41 | 152 ± 62 | n.s. |
LV ejection fraction (%) | 51 ± 14 | 54 ± 13 | n.s. |
LV midwall fractional shortening (%) | 11.9 ± 3.9 | 14.1 ± 3.7 | 0.001 |
Low LV midwall fractional shortening, n (%) | 39 (78%) | 48 (60%) | 0.03 |
Stroke volume index (mL/m2) | 33 ± 10 | 38 ± 12 | 0.01 |
cESS (hPa) | 247 ± 105 | 209 ± 84 | 0.025 |
Zva (mm Hg per mL/m2) | 5.8 ± 2.2 | 5.1 ± 1.8 | 0.04 |
Pulse pressure (mm Hg) | 63 ± 14 | 64 ± 17 | n.s. |
Systemic arterial compliance (mL/m2 per mm Hg) | 0.53 ± 0.16 | 0.62 ± 0.22 | 0.01 |