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Breast Cancer Research
Erschienen in: Breast Cancer Research 1/2003

01.02.2003 | Review

Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer

verfasst von: Angel Alkarain, Joyce Slingerland

Erschienen in: Breast Cancer Research | Ausgabe 1/2003

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Abstract

p27 is a key regulator of progression from G1 to S phase. Although the gene encoding p27 is rarely mutated in human cancers, p27 is functionally inactivated in a majority of human cancers through accelerated p27 proteolysis, through sequestration by cyclin D–cyclin-dependent kinase complexes and by cytoplasmic mislocalization. Here we review mechanisms whereby oncogenic activation of receptor tyrosine kinase and Ras pathways lead to accelerated p27 proteolysis and p27 mislocalization in cancer cells. The prognostic significance of p27 in human breast cancer is also reviewed.
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Metadaten
Titel
Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer
verfasst von
Angel Alkarain
Joyce Slingerland
Publikationsdatum
01.02.2003
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 1/2003
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr722

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