Erschienen in:
15.06.2018 | Original Communication
Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML
verfasst von:
Jeremias Motte, Janina Kneiphof, Katrin Straßburger-Krogias, Anja Klasing, Ortwin Adams, Aiden Haghikia, Ralf Gold
Erschienen in:
Journal of Neurology
|
Ausgabe 8/2018
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Abstract
We report a 76-year-old MS patient, treated with DMF for 3 years. Lymphocytes never showed values below 1240/µl. CSF analysis revealed 1,988,880 copies/ml of JCV-DNA, JCV-DNA was detectable in serum and anti-JCV-antibody in CSF and serum were highly positive. Stratify®-JCV-test was positive. CD8-positive T-lymphocytes were reduced. Therapy with mefloquine, mirtazapine and cidofovir resulted in complete elimination of the virus in serum and 90% reduction of viral load in CSF. This case shows that despite careful monitoring for lymphopenia JCV spreading to the CSF may occur during treatment with DMF.