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Annals of Nuclear Medicine

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01.04.2016 | Original Article

Development of a simple non-invasive microsphere quantification method for cerebral blood flow using I-123-IMP

verfasst von: Asato Ofuji, Hiroaki Mimura, Kosuke Yamashita, Akihiro Takaki, Teruki Sone, Shigeki Ito

Erschienen in: Annals of Nuclear Medicine | Ausgabe 3/2016

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Abstract

Objective

In clinical practice, measurement of the rCBF has mainly been conducted by I-123-N-isopropyl-p-iodoamphetamine (¹²³I-IMP) SPECT using the microsphere (MS) method, with continuous arterial blood sampling. While several non-invasive ¹²³I-IMP quantification methods have been developed, their accuracy has been shown to be lower than that of the MS method. Therefore, a non-invasive quantification method for use in routine clinical practice is being sought. The purpose of this study was to develop a simple non-invasive ¹²³I-IMP quantification method (SIMS method) with a simple input function-determining protocol based on the MS method.

Method

The input function for the SIMS method was determined using the administered dose and the integrated lung washout ratio obtained by analyzing the count–time activity curve of the pulmonary artery and lung on dynamic chest images. The mean CBF (mCBF) and input function measured in 80 patients by the SIMS method was compared with those determined using the MS method.

Result

A good correlation was observed between the counts measured by continuous arterial blood sampling in the MS method and the estimated counts by image analysis in the new method (r = 0.94, p < 0.01). Similarly, a good correlation was observed between the mCBF values determined by the MS method and the SIMS method (r = 0.83, p < 0.01).

Conclusion

The mCBF values determined by the SIMS method were closely consistent with the values obtained by the MS method. This finding indicates the possibility of use of the SIMS method for routine clinical study.

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Titel: Development of a simple non-invasive microsphere quantification method for cerebral blood flow using I-123-IMP
verfasst von: Asato Ofuji
Hiroaki Mimura
Kosuke Yamashita
Akihiro Takaki
Teruki Sone
Shigeki Ito
Publikationsdatum: 01.04.2016
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 3/2016
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-015-1053-8

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Development of a simple non-invasive microsphere quantification method for cerebral blood flow using I-123-IMP

Abstract

Objective

Method

Result

Conclusion

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Objective

Method

Result

Conclusion

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