Erschienen in:
20.08.2016 | Case Report
Development of acute lymphoblastic leukemia with IgH-EPOR in a patient with secondary erythrocytosis
verfasst von:
Kenichi Sakamoto, Seiji Tanaka, Chihiro Tomoyasu, Toshihiro Tomii, Mio Yano, Kazutaka Takagi, Tsutsumi Yasuhiko, Nobuhiko Uoshima, Hiroshi Komatsu, Toshihiko Imamura
Erschienen in:
International Journal of Hematology
|
Ausgabe 6/2016
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Abstract
We report the first patient to develop ALL with a fusion gene of the erythropoietin receptor (EPOR) with immunoglobulin heavy chain (IgH) 22 years after a diagnosis of secondary erythrocytosis with unknown etiology. The IgH-EPOR rearrangement is known to induce increased expression of EPOR, and activates EPO-associated signal pathways by exogenous EPO stimulation, resulting in the increased proliferation and survival of IgH-EPOR-positive leukemic cells. Interestingly, this case may provide supporting the possibility that IgH-EPOR-positive ALL has a growth advantage under sustained high concentrations of EPO.