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02.03.2024 | Neurology and Preclinical Neurological Studies - Original Article

Differential patterns of functional connectivity in tremor dominant Parkinson’s disease and essential tremor plus

verfasst von: Shweta Prasad, Jitender Saini, Rose Dawn Bharath, Pramod Kumar Pal

Erschienen in: Journal of Neural Transmission

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Abstract

Tremor dominant Parkinson’s disease (TDPD) and essential tremor plus (ETP) syndrome are commonly encountered tremor dominant neurological disorders. Although the basal ganglia thalamocortical (BGTC) and cerebello thalamocortical (CTC) networks are implicated in tremorogenesis, the extent of functional connectivity alterations across disorders is uncertain. This study aims to evaluate functional connectivity of the BGTC and CTC in TDPD and ETP. Resting state functional MRI was acquired for 25 patients with TDPD, ETP and 22 healthy controls (HC). Following pre-processing and denoising, seed-to-voxel based connectivity was carried out at FDR < 0.05 using ROIs belonging to the BGTC and CTC. Fahn-Tolosa-Marin tremor rating scale (FTMRS) was correlated with the average connectivity values at FDR < 0.05. Compared to HC, TDPD showed decreased connectivity between cerebellum and pre, post central gyrus. While, ETP showed decreased connectivity between pallidum and occipital cortex, precuneus, cuneus compared to HC. In comparison to ETP, TDPD showed increased connectivity between precentral gyrus, pallidum, SNc with the default mode network (DMN), and decreased connectivity between cerebellum with superior, middle frontal gyrus was observed. Tremor severity positively correlated with connectivity between SNc and DMN in TDPD, and negatively correlated with pallidal connectivity in ETP. Pattern of BGTC, CTC involvement is differential i.e., higher connectivity of the BGTC nodes in TDPD, and higher connectivity of cerebellar nodes in ETP. The interesting observation of pallidal involvement in ETP suggests the role of BGTC in the pathogenesis of ETP, and indicated similarities in concepts of tremor genesis in TDPD and ETP.

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Titel: Differential patterns of functional connectivity in tremor dominant Parkinson’s disease and essential tremor plus
verfasst von: Shweta Prasad
Jitender Saini
Rose Dawn Bharath
Pramod Kumar Pal
Publikationsdatum: 02.03.2024
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-024-02761-7

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