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01.12.2017 | Case report | Ausgabe 1/2017 Open Access

BMC Cancer 1/2017

Dilemmas in a pregnant woman with myelofibrosis secondary to signet ring adenocarcinoma: a case report

BMC Cancer > Ausgabe 1/2017
Pujun Guan, Zihang Chen, Li Zhang, Ling Pan



We describe the first reported case of myelofibrosis as an extremely rare complication of gastric cancer during pregnancy; the clinical diagnosis and treatment of which is highly challenging due to nonspecific symptoms coupled with the conflicting needs of immediate disease control and continuation of pregnancy.

Case presentation

We report a 36-year-old pregnant woman who presented with cytopenia, fatigue, vomiting, and diarrhea for 20 days on the background of newly diagnosed myelofibrosis secondary to gastric signet ring adenocarcinoma. She accepted palliative care and died several months after the delivery of a healthy newborn.


Signet ring gastric adenocarcinoma is an unusual cause of myelofibrosis during pregnancy. Treatment remains a great challenge as clinicians have to consider the needs of immediate treatment against fetal well-being while taking into account patient preference and fetus rights.
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