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Journal of Mammary Gland Biology and Neoplasia

Erschienen in:

01.06.2013

Does Cancer Start in the Womb? Altered Mammary Gland Development and Predisposition to Breast Cancer due to in Utero Exposure to Endocrine Disruptors

verfasst von: Ana M. Soto, Cathrin Brisken, Cheryl Schaeberle, Carlos Sonnenschein

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 2/2013

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Abstract

We are now witnessing a resurgence of theories of development and carcinogenesis in which the environment is again being accepted as a major player in phenotype determination. Perturbations in the fetal environment predispose an individual to disease that only becomes apparent in adulthood. For example, gestational exposure to diethylstilbestrol resulted in clear cell carcinoma of the vagina and breast cancer. In this review the effects of the endocrine disruptor bisphenol-A (BPA) on mammary development and tumorigenesis in rodents is used as a paradigmatic example of how altered prenatal mammary development may lead to breast cancer in humans who are also widely exposed to it through plastic goods, food and drink packaging, and thermal paper receipts. Changes in the stroma and its extracellular matrix led to altered ductal morphogenesis. Additionally, gestational and lactational exposure to BPA increased the sensitivity of rats and mice to mammotropic hormones during puberty and beyond, thus suggesting a plausible explanation for the increased incidence of breast cancer.

Laplacian determination is the one operating in computers where complete knowledge of the state at one moment completely determines its state at all future moments.

A dose of 250 μg/kg/day resulted in unconjugated BPA serum levels in the range of those found in humans (unpublished data, AMS and CS)

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Titel: Does Cancer Start in the Womb? Altered Mammary Gland Development and Predisposition to Breast Cancer due to in Utero Exposure to Endocrine Disruptors
verfasst von: Ana M. Soto
Cathrin Brisken
Cheryl Schaeberle
Carlos Sonnenschein
Publikationsdatum: 01.06.2013
Verlag: Springer US
Erschienen in: Journal of Mammary Gland Biology and Neoplasia / Ausgabe 2/2013
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-013-9293-5

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Does Cancer Start in the Womb? Altered Mammary Gland Development and Predisposition to Breast Cancer due to in Utero Exposure to Endocrine Disruptors

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